PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DEC1	0	PPP2R1A	8	two hybrid	Wallach T (2013)	1
ARNTL2	0	CIPC	2	affinity chromatography technology	Huttlin EL (2017)	1
CLOCK	0	RORC	4	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
HDAC1	4	BHLHE41	0	pull down, affinity chromatography technology, biochemical, imaging technique	Fujimoto K (2007), Li Y (2011), Matsunaga N (2012), Matsunaga N (2012)	4
RORB	3	NCOA6	6	two hybrid	Albers M (2005)	1
NCOA6	6	SRC	2	pull down, two hybrid	Lee SK (2000), Lee SK (2001)	2
CLOCK	0	PPP1CB	9	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
EP300	36	CLOCK	0	pull down	Curtis AM (2004)	1
RORC	4	ANKHD1-EIF4EBP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CLOCK	0	BHLHE41	0	two hybrid	Wallach T (2013)	1
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
CIPC	2	RORC	4	two hybrid	Wallach T (2013)	1
PSMC5	4	USP4	3	pull down, affinity chromatography technology, affinity chromatography technology	Zhao B (2012), Zhao B (2012), Huttlin EL (2017)	3
ARNTL	2	RORC	4	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
HDAC1	4	PPP1CC	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gao J (2009), Brush MH (2004), Canettieri G (2003), Canettieri G (2003)	4
DEC1	0	NR1D2	1	two hybrid	Wallach T (2013)	1
PPP2R5D	29	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology	McCright B (1996), McCright B (1996), Sablina AA (2007), Havugimana PC (2012), Wallach T (2013), Wan C (2015), Hein MY (2015)	7
CLOCK	0	CSNK1E	0	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
PPP2CA	7	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017)	8
NCOA6	6	RORC	4	two hybrid	Albers M (2005)	1
CLOCK	0	DEC1	0	two hybrid	Wallach T (2013)	1
DEC1	0	FBXL15	0	two hybrid	Wallach T (2013)	1
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
CSNK1E	0	RORC	4	two hybrid	Wallach T (2013)	1
BHLHE41	0	PPP2R5E	4	two hybrid	Wallach T (2013)	1
PPP2R5E	4	RORC	4	two hybrid	Wallach T (2013)	1
PPP2R1A	8	HDAC1	4	affinity chromatography technology	Sablina AA (2007)	1
RORC	4	CTSA	2	affinity chromatography technology	Huttlin EL (2017)	1
RORC	4	SCGB1D2	0	affinity chromatography technology	Huttlin EL (2017)	1
BHLHE41	0	PPP2R1B	4	two hybrid	Wallach T (2013)	1
DEC1	0	RORC	4	two hybrid	Wallach T (2013)	1
TRAF5	1	RORC	4	affinity chromatography technology, affinity chromatography technology	Wang X (2015), Wang X (2015)	2
DEC1	0	PPP2R1B	4	two hybrid	Wallach T (2013)	1
CLOCK	0	NPAS2	0	two hybrid	Wallach T (2013)	1
CSNK1E	0	PPP2R5E	4	two hybrid	Wallach T (2013)	1
PPP1CA	3	RORC	4	two hybrid	Wallach T (2013)	1
PSMC5	4	RORC	4	two hybrid	Albers M (2005)	1
EP300	36	SRC	2	affinity chromatography technology, affinity chromatography technology	Paladino D (2016), Paladino D (2016)	2
ARNTL	2	ARNTL2	0	affinity chromatography technology	Huttlin EL (2017)	1
DEC1	0	PPP2R5D	29	two hybrid	Wallach T (2013)	1
DEC1	0	HDAC1	4	affinity chromatography technology	Li Y (2011)	1
EP300	36	ARNTL	2	pull down	Curtis AM (2004)	1
EP300	36	RORC	4	affinity chromatography technology	Wu Q (2015)	1
PPP2CA	7	PPP2R1B	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Yadav L (2017)	10
BHLHE41	0	RORC	4	two hybrid	Wallach T (2013)	1
RORC	4	GLB1	3	affinity chromatography technology	Huttlin EL (2017)	1
DEC1	0	PPP2CA	7	two hybrid	Wallach T (2013)	1
RORB	3	RORC	4	two hybrid	Wallach T (2013)	1
CLOCK	0	PER2	11	two hybrid	Wallach T (2013)	1
ARNTL	2	DEC1	0	two hybrid	Wallach T (2013)	1
EP300	36	PPP2CA	7	affinity chromatography technology	Chen J (2005)	1
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
CLOCK	0	PPP1CA	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Wallach T (2013), Wallach T (2013), Wallach T (2013)	3
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ARNTL2	0	RORC	4	two hybrid	Wallach T (2013)	1
RORC	4	USP15	4	affinity chromatography technology	He Z (2016)	1
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
CSNK1E	0	PPP1CC	2	two hybrid	Wallach T (2013)	1
USP4	3	RORC	4	affinity chromatography technology	Yang J (2015)	1
PPP2CA	7	RORC	4	two hybrid	Wallach T (2013)	1
FBXL15	0	RORC	4	two hybrid	Wallach T (2013)	1
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
PPP1CB	9	RORC	4	two hybrid	Wallach T (2013)	1
TP53	0	CSNK1E	0	imaging technique	Chen TC (2014)	1
CLOCK	0	PPP2R5D	29	two hybrid	Wallach T (2013)	1
PPP2R1B	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Sablina AA (2007), Sablina AA (2007)	2
CLOCK	0	PPP2R1B	4	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
NR1D2	1	HDAC1	4	pull down, pull down	Muscat GE (1998), Wang J (2008)	2
RORB	3	PSMC5	4	two hybrid	Albers M (2005)	1
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
DEC1	0	PPP2R5E	4	two hybrid	Wallach T (2013)	1
DEC1	0	PER2	11	two hybrid	Wallach T (2013)	1
CIPC	2	CLOCK	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Wallach T (2013), Huttlin EL (2015), Huttlin EL (2017)	3
PPP1CC	2	TP53	0	affinity chromatography technology	Flores-Delgado G (2007)	1
CSNK1E	0	PER2	11	two hybrid, affinity chromatography technology	Wallach T (2013), Huttlin EL (2017)	2
PPP2R1B	4	RORC	4	two hybrid	Wallach T (2013)	1
NPAS2	0	ARNTL	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology	McNamara P (2001), McNamara P (2001), Hogenesch JB (1998), Hogenesch JB (1998), Hogenesch JB (1998), Corominas R (2014), Wallach T (2013), Huttlin EL (2017)	8
RORC	4	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
CTSA	2	GLB1	3	affinity chromatography technology	Boldt K (2016)	1
BHLHE41	0	PER2	11	two hybrid	Wallach T (2013)	1
DEC1	0	RORB	3	two hybrid	Wallach T (2013)	1
PER2	11	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Gotoh T (2014), Gotoh T (2014), Gotoh T (2014), Gotoh T (2014), Gotoh T (2016), Gotoh T (2016)	6
PPP1CC	2	RORC	4	two hybrid	Wallach T (2013)	1
CSNK1E	0	DEC1	0	two hybrid	Wallach T (2013)	1
DEC1	0	NPAS2	0	two hybrid	Wallach T (2013)	1
PPP2R1A	8	RORC	4	two hybrid	Wallach T (2013)	1
CLOCK	0	PPP1CC	2	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
HDAC1	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Guo C (2007), Chen CS (2005)	2
EVI2A	1	RORC	4	two hybrid	Wang J (2011)	1
CLOCK	0	ARNTL	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Ooe N (2004), McNamara P (2001), McNamara P (2001), Hogenesch JB (1998), Hosoda H (2009), Alhopuro P (2010), Wallach T (2013), Wallach T (2013), Lee Y (2015), Huttlin EL (2017), Boldt K (2016)	11
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
PPP2R5D	29	RORC	4	two hybrid	Wallach T (2013)	1
NCOA6	6	EP300	36	affinity chromatography technology, pull down	Ko L (2000), Ko L (2000)	2
DEC1	0	PPP1CA	3	two hybrid	Wallach T (2013)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
CLOCK	0	NR1D2	1	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
CSNK1E	0	PPP2R5D	29	two hybrid	Wallach T (2013)	1
CLOCK	0	RORB	3	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
PPP2R5E	4	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	McCright B (1996), McCright B (1996), Sablina AA (2007), Sablina AA (2007), Wallach T (2013), Wan C (2015)	6
NPAS2	0	ARNTL2	0	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
RORC	4	SRC	2	affinity chromatography technology	He Z (2016)	1
NPAS2	0	RORC	4	two hybrid	Wallach T (2013)	1
HDAC1	4	RORC	4	affinity chromatography technology, affinity chromatography technology	Wu Q (2015), Wu Q (2015)	2
PPP2R1A	8	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	9
DEC1	0	PPP1CC	2	two hybrid	Wallach T (2013)	1
PPP2R1A	8	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Havugimana PC (2012), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	11
PPP1CA	3	TP53	0	two hybrid	Colland F (2004)	1
CLOCK	0	ARNTL2	0	two hybrid, affinity chromatography technology	Ooe N (2004), Huttlin EL (2017)	2
DEC1	0	PPP1CB	9	two hybrid	Wallach T (2013)	1
CSNK1E	0	BHLHE41	0	two hybrid	Wallach T (2013)	1
PPP2CA	7	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	10
PPP1CA	3	ARNTL	2	affinity chromatography technology	Wallach T (2013)	1
PPP1CA	3	CSNK1E	0	enzymatic study	Luo W (2007)	1
DEC1	0	BHLHE41	0	two hybrid	Wallach T (2013)	1
PPP1CA	3	PPP2R5D	29	affinity chromatography technology	Grallert A (2015)	1
CLOCK	0	PPP2R5E	4	two hybrid	Wallach T (2013)	1
PPP2R1A	8	PPP2R1B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Sablina AA (2007), Fogeron ML (2013), Wan C (2015), Hein MY (2015)	5
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
CSNK1E	0	ARNTL	2	enzymatic study, two hybrid	Eide EJ (2002), Wallach T (2013)	2
NR1D2	1	RORC	4	two hybrid	Wallach T (2013)	1
EP300	36	NPAS2	0	pull down, pull down	Curtis AM (2004), Curtis AM (2004)	2
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30
PER2	11	RORC	4	two hybrid	Wallach T (2013)	1
CSNK1E	0	NR1D2	1	two hybrid	Wallach T (2013)	1
CIPC	2	DEC1	0	two hybrid	Wallach T (2013)	1
PPP1CA	3	PPP2R5E	4	two hybrid	Wallach T (2013)	1