PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZUFSP	0	BLM	2	affinity chromatography technology	Kwasna D (2018)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
RPA1	0	PRPF19	2	affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology	Marechal A (2014), Marechal A (2014), Marechal A (2014), Marechal A (2014), Elia AE (2015)	5
BLM	2	WRN	6	affinity chromatography technology, pull down	von Kobbe C (2002), von Kobbe C (2002)	2
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
RPA4	0	RPA1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Keshav KF (1995), Keshav KF (1995), Ghospurkar PL (2014), Huttlin EL (2015), Huttlin EL (2017)	5
RPA3	2	PRPF19	2	affinity chromatography technology, pull down, pull down	Marechal A (2014), Marechal A (2014), Marechal A (2014)	3
RFWD3	5	RPA3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Liu S (2011), Gong Z (2011), Gong Z (2011), Marechal A (2014), Inano S (2017), Kwasna D (2018)	6
BLM	2	RPA1	0	pull down, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brosh RM (2000), Opresko PL (2002), Moens PB (2002), Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Wang J (2013), Marechal A (2014), Chaudhury I (2014), Elia AE (2015)	10
RPA4	0	RPA2	0	two hybrid, affinity chromatography technology	Keshav KF (1995), Keshav KF (1995)	2
RPA2	0	RAD52	5	affinity chromatography technology	Jackson D (2002)	1
RAD52	5	RPA3	2	affinity chromatography technology, affinity chromatography technology	Du Y (2009), Du Y (2009)	2
RPA1	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
RPA4	0	RPA3	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Keshav KF (1995), Keshav KF (1995), Huttlin EL (2015), Huttlin EL (2017)	4
ZUFSP	0	RPA2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hermanns T (2018), Hermanns T (2018), Kwasna D (2018)	3
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
RPA3	2	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Boldt K (2016)	2
CDC5L	2	PRPF19	2	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, far western blotting, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Song EJ (2010), Lu X (2007), Grote M (2010), Grote M (2010), Havugimana PC (2012), Wan C (2015), Lleres D (2010), Huttlin EL (2017)	10
RPA2	0	FBXO18	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Jeong YT (2013), Jeong YT (2013)	3
WRN	6	RAD52	5	pull down, pull down, far western blotting, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Baynton K (2003), Baynton K (2003), Baynton K (2003), Baynton K (2003), Baynton K (2003)	8
ZUFSP	0	RPA3	2	affinity chromatography technology, affinity chromatography technology	Hermanns T (2018), Kwasna D (2018)	2
RPA1	0	TCOF1	1	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	SMARCAL1	7	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Kwasna D (2018)	2
RPA3	2	FBXO18	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Jeong YT (2013), Jeong YT (2013)	3
RPA1	0	CDC5L	2	affinity chromatography technology, pull down, affinity chromatography technology	Marechal A (2014), Marechal A (2014), Lleres D (2010)	3
RFWD3	5	RPA2	0	imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Liu S (2011), Liu S (2011), Liu S (2011), Gong Z (2011), Gong Z (2011), Gong Z (2011), Marechal A (2014), Elia AE (2015), Feeney L (2017), Inano S (2017), Kwasna D (2018)	11
RPA3	2	ATRIP	1	affinity chromatography technology, pull down	Marechal A (2014), Tomida J (2013)	2
RPA2	0	PRPF19	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Marechal A (2014), Marechal A (2014), Marechal A (2014), Marechal A (2014), Marechal A (2014), Marechal A (2014)	6
ZUFSP	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hermanns T (2018), Kwasna D (2018), Haahr P (2018)	3
RPA2	0	WRN	6	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
BLM	2	RPA3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meetei AR (2003), Meetei AR (2003), Marechal A (2014)	3
RPA2	0	ATRIP	1	affinity chromatography technology, pull down	Marechal A (2014), Tomida J (2013)	2
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
WRN	6	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Zhang N (2005), Zhang N (2005)	2
RPA3	2	TCOF1	1	affinity chromatography technology, genetic interference	Marechal A (2014), Horlbeck MA (2018)	2
RPA3	2	SMARCAL1	7	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Kwasna D (2018)	2
RFWD3	5	RPA1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Liu S (2011), Liu S (2011), Liu S (2011), Gong Z (2011), Gong Z (2011), Gong Z (2011), Marechal A (2014), Elia AE (2015), Feeney L (2017), Inano S (2017), Kwasna D (2018)	11
RPA1	0	SMARCAL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gong Z (2011), Marechal A (2014), Elia AE (2015), Kwasna D (2018)	4
RPA1	0	RAD52	5	pull down	Sugiyama T (2002)	1
RPA2	0	TCOF1	1	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	FBXO18	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Jeong YT (2013), Jeong YT (2013)	3
BLM	2	RPA2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meetei AR (2003), Meetei AR (2003), Marechal A (2014)	3
ATRIP	1	RPA1	0	imaging technique, pull down, affinity chromatography technology, pull down, pull down	Zou L (2003), Liu Y (2011), Marechal A (2014), Tomida J (2013), Shigechi T (2012)	5