PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IL17RA	3	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
FYN	1	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
FGFR2	6	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
RPS6KA2	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roux PP (2003), Zhao Y (1996), Varjosalo M (2013), So J (2015)	4
IL17RA	3	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA1	3	RPS6KA2	2	affinity chromatography technology	Varjosalo M (2013)	1
HNRNPL	3	NQO2	0	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	RPS6KA2	2	affinity chromatography technology	Nakajima T (1996)	1
SPRED2	12	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
RPS6KA2	2	STXBP2	6	biochemical	Havugimana PC (2012)	1
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
TRIM25	5	SHROOM3	7	affinity chromatography technology	Choudhury NR (2017)	1
RPS6KA2	2	JUN	0	enzymatic study	Zhao Y (1995)	1
ZMYM5	1	RPS6KA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALOX5	1	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
RPS6KA2	2	FAT1	12	affinity chromatography technology	So J (2015)	1
HNRNPL	3	RPS6KA2	2	affinity chromatography technology	Fei T (2017)	1
RPS6KA1	3	MAPK3	4	affinity chromatography technology	Roux PP (2003)	1
MAPK3	4	CREBBP	29	enzymatic study	Tsai LN (2008)	1
RPS6KA2	2	FOS	0	enzymatic study	Zhao Y (1995)	1
TRIM25	5	MISP	4	affinity chromatography technology	Choudhury NR (2017)	1
ECE2	6	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2015)	1
FOS	0	MAPK1	1	affinity chromatography technology	Kumar NV (2001)	1
RPS6KA2	2	SHROOM3	7	affinity chromatography technology	So J (2015)	1
MISP	4	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
FLNC	8	RPS6KA2	2	two hybrid	Wang J (2011)	1
MAPK3	4	JUN	0	enzymatic study	Pulverer BJ (1991)	1
TRIM11	1	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA2	2	RPS6KA2	2	enzymatic study	Zhao Y (1995)	1
FYN	1	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
HSP90AA1	7	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Varjosalo M (2013)	2
JUN	0	HSP90AA1	7	two hybrid, pull down	Bandyopadhyay S (2010), Miyamoto-Sato E (2010)	2
MISP	4	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
IRGC	1	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA2	2	MAPK3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Roux PP (2003), Zhao Y (1996), Varjosalo M (2013), Chen TC (2014)	4
IRGC	1	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	RPS6KA2	2	affinity chromatography technology	Taipale M (2012)	1
RPS6KA2	2	GRSF1	1	affinity chromatography technology	So J (2015)	1
FGFR2	6	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
FYN	1	FGFR2	6	affinity chromatography technology	Kaabeche K (2004)	1
STRADB	1	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RPS6KA1	3	CSNK2B	5	affinity chromatography technology	Varjosalo M (2013)	1
TRIM25	5	RPS6KA2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	GRSF1	1	affinity chromatography technology	Choudhury NR (2017)	1
RPS6KA2	2	NQO2	0	biochemical	Havugimana PC (2012)	1
RPS6KA1	3	MAPK1	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Roux PP (2003), Eblen ST (2003), Smith JA (1999), Ding Q (2005), Varjosalo M (2013), Jahrling JB (2014), Smith JA (2000)	7
CREBBP	29	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology	Fang X (2005), Wang Z (2003)	2
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
CSNK2B	5	RPS6KA2	2	two hybrid	Wang J (2011)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
HNRNPL	3	SHROOM3	7	affinity chromatography technology	Fei T (2017)	1