PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
KDM1A	2	CTBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Lee MG (2005), Kuppuswamy M (2008), Kuppuswamy M (2008), Keutgens A (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
RREB1	6	ARL6	0	affinity chromatography technology	Boldt K (2016)	1
TRIM25	5	CTBP1	2	affinity chromatography technology	Choudhury NR (2017)	1
KDM1A	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013)	4
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
RREB1	6	NEK7	0	affinity chromatography technology	Boldt K (2016)	1
HDAC1	4	HIST3H3	0	enzymatic study, unspecified method	Shi Y (2003), Vermeulen M (2010)	2
SFMBT1	0	KDM1A	2	affinity chromatography technology	Hauri S (2016)	1
RREB1	6	AR	3	affinity chromatography technology	Mukhopadhyay NK (2007)	1
CTBP1	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Koipally J (2000), Glasspool RM (2005), Kuppuswamy M (2008), Kuppuswamy M (2008), Mendez LM (2008)	5
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
RREB1	6	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Joshi P (2013)	2
TRIM25	5	RREB1	6	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	TOR1AIP2	2	affinity chromatography technology	Choudhury NR (2017)	1
SNCA	0	RREB1	6	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	NEK7	0	affinity chromatography technology	Choudhury NR (2017)	1
SFMBT1	0	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
HDAC2	1	RREB1	6	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013)	2
AR	3	HDAC3	5	pull down, affinity chromatography technology	Franco PJ (2003), Zhu P (2006)	2
SPATA20	2	RREB1	6	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	SFMBT1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
HDAC2	1	HIST3H3	0	enzymatic study	Shi Y (2003)	1
HDAC2	1	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, genetic interference	Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Tong JK (1998), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Wang Y (2009), Li Q (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Wong AS (2016)	17
BLM	2	RREB1	6	genetic interference	Vizeacoumar FJ (2013)	1
KDM1A	2	RREB1	6	affinity chromatography technology	Shi YJ (2005)	1
HDAC3	5	CTBP1	2	pull down	Zhang CL (2001)	1
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
CTBP1	2	HIST3H3	0	enzymatic study	Shi Y (2003)	1
HDAC1	4	RREB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
TOR1AIP2	2	ARL6	0	affinity chromatography technology	Boldt K (2016)	1
CTBP1	2	RREB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuppuswamy M (2008), Huttlin EL (2015), Huttlin EL (2017)	3
AR	3	KDM1A	2	affinity chromatography technology, bioid	Choi H (2016), Lempiaeinen JK (2017)	2
RREB1	6	TOR1AIP2	2	affinity chromatography technology	Boldt K (2016)	1
SFMBT1	0	RREB1	6	affinity chromatography technology	Hauri S (2016)	1
RREB1	6	HIST3H3	0	enzymatic study	Shi Y (2003)	1