PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
S100A1	1	PYGM	0	affinity chromatography technology, pull down	Kiewitz R (2003), Kiewitz R (2003)	2
MDM2	2	S100A4	0	pull down	van Dieck J (2010)	1
S100A1	1	PLEKHF2	1	two hybrid	Rolland T (2014)	1
DES	1	S100A1	1	pull down	Garbuglia M (1996)	1
S100A1	1	S100A4	0	two hybrid, two hybrid, pull down, far western blotting	Rual JF (2005), Wang G (2000), Wang G (2000), Wang G (2000)	4
FKBP4	0	S100A2	0	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
S100A1	1	S100B	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Rual JF (2005), Deloulme JC (2000), Deloulme JC (2000), Yang Q (1999), Rolland T (2014), Yu H (2011)	6
S100A2	0	S100B	0	two hybrid	Rolland T (2014)	1
ANXA6	4	S100A1	1	pull down	Garbuglia M (1998)	1
S100A1	1	GJA1	0	affinity chromatography technology, pull down	Kiewitz R (2003), Kiewitz R (2003)	2
MDM2	2	S100B	0	pull down	van Dieck J (2010)	1
S100A1	1	PLB1	7	affinity chromatography technology, pull down	Kiewitz R (2003), Kiewitz R (2003)	2
FKBP4	0	S100A1	1	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
PPID	0	S100A1	1	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
S100A1	1	S100A2	0	two hybrid	Rolland T (2014)	1
MDM2	2	S100A2	0	pull down	van Dieck J (2010)	1
S100B	0	S100P	1	two hybrid, affinity chromatography technology	Rolland T (2014), Hein MY (2015)	2
MDM2	2	ATP2A2	7	unspecified method	Nicholson J (2014)	1
BAG3	4	S100P	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
PGM1	2	S100A1	1	far western blotting, affinity chromatography technology	Landar A (1996), Landar A (1996)	2
S100A1	1	ATP2A2	7	affinity chromatography technology, pull down	Kiewitz R (2003), Kiewitz R (2003)	2
BAG3	4	S100B	0	affinity chromatography technology	Chen Y (2013)	1
MDM2	2	S100A1	1	pull down	van Dieck J (2010)	1
S100A1	1	NIF3L1	0	two hybrid	Rual JF (2005)	1
S100A1	1	RYR1	18	pull down	Treves S (1997)	1
PPID	0	S100A2	0	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
S100A4	0	S100B	0	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Hein MY (2015)	3
BAG3	4	S100A1	1	affinity chromatography technology	Chen Y (2013)	1
ANXA6	4	S100B	0	pull down	Garbuglia M (1998)	1
S100A1	1	S100P	1	two hybrid	Rual JF (2005)	1
PGM1	2	S100B	0	far western blotting, affinity chromatography technology	Landar A (1996), Landar A (1996)	2
S100A1	1	S100A1	1	two hybrid, biochemical, two hybrid	Rual JF (2005), Osterloh D (1998), Rolland T (2014)	3