PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RELA	1	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Yang W (2012), Yang W (2012)	2
MTA1	3	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yan C (2003), Khaleque MA (2008), Xue Y (1998), Wan C (2015)	4
HSPE1	0	TLE1	6	two hybrid	Stelzl U (2005)	1
TLE1	6	RELA	1	affinity chromatography technology	Tetsuka T (2000)	1
SNAI2	0	TP53	0	affinity chromatography technology	Kao SH (2014)	1
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
HOXB9	0	SAT1	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
CHD3	19	ZHX1	1	two hybrid	Goehler H (2004)	1
SAT1	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
SAT1	0	MED31	0	two hybrid	Stelzl U (2005)	1
PRDX2	1	SAT1	0	two hybrid	Wang J (2011)	1
SAT1	0	INO80C	1	two hybrid	Stelzl U (2005)	1
CCHCR1	2	RBM17	1	two hybrid	Rolland T (2014)	1
SAT1	0	EEF1G	0	two hybrid	Stelzl U (2005)	1
LUC7L2	0	PTN	0	two hybrid	Stelzl U (2005)	1
HSPE1	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
HSPE1	0	APLP1	1	two hybrid	Stelzl U (2005)	1
SAT1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
RPLP1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
SAT1	0	EPHB6	4	two hybrid	Stelzl U (2005)	1
TP53	0	TUBB2A	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
RACK1	2	TSC22D4	1	two hybrid	Rual JF (2005)	1
SAT1	0	COPS6	0	two hybrid	Stelzl U (2005)	1
KAT5	1	APLP1	1	two hybrid	Li Q (2004)	1
SAT1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
TP53	0	DGKZ	6	affinity chromatography technology, affinity chromatography technology, pull down	Tanaka T (2013), Tanaka T (2013), Tanaka T (2013)	3
APLP1	1	RBM48	1	two hybrid	Goehler H (2004)	1
HSPB1	2	RBM48	1	two hybrid	Stelzl U (2005)	1
KAT7	3	LRIF1	3	two hybrid	Goehler H (2004)	1
EVA1A	0	PTN	0	two hybrid	Stelzl U (2005)	1
SAT1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
HSPB1	2	CCHCR1	2	two hybrid	Katsogiannou M (2014)	1
HIF1A	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yoo YG (2006), Yoo YG (2006), Yoo YG (2006), Moon HE (2006), Moon HE (2006)	5
MRPL9	0	SAT1	0	two hybrid	Venkatesan K (2009)	1
SAT1	0	DMRT3	2	two hybrid	Rolland T (2014)	1
SAT1	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
EEF1G	0	MED31	0	two hybrid	Stelzl U (2005)	1
CCDC148	0	SAT1	0	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
CASP7	1	GBP2	0	biochemical	Kristensen AR (2012)	1
VKORC1	1	SAT1	0	two hybrid	Schaafhausen A (2011)	1
HIF1A	1	RACK1	2	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baek JH (2007), Liu YV (2007), Liu YV (2007), Liu YV (2007), Sun H (2013), Amir S (2009), Kuo YC (2015), Lee SH (2015)	8
SAT1	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
TP53	0	MTA1	3	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yao YL (2003), Li DQ (2010), Moon HE (2007), Moon HE (2007), Li DQ (2009), Li DQ (2009)	6
SAT1	0	GBP2	0	two hybrid	Stelzl U (2005)	1
TP53	0	UTP14A	0	pull down, pull down, affinity chromatography technology	Hu L (2011), Hu L (2011), Hu L (2011)	3
HSPB1	2	LRIF1	3	two hybrid	Stelzl U (2005)	1
SAT1	0	SAT1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LUC7L2	0	CHD3	19	two hybrid	Stelzl U (2005)	1
KAT7	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Iizuka M (2008), Iizuka M (2008), Iizuka M (2008)	3
HSPB1	2	SAT1	0	two hybrid	Katsogiannou M (2014)	1
FTSJ3	2	UTP14A	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
SAT1	0	RPLP1	0	two hybrid	Stelzl U (2005)	1
SAT1	0	FAM69B	0	two hybrid	Rolland T (2014)	1
SAT1	0	TCF25	0	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Yu H (2011)	4
SAT1	0	B4GALT3	0	two hybrid	Stelzl U (2005)	1
SEPHS1	0	HSPB1	2	biochemical	Wan C (2015)	1
SAT1	0	DDX39A	3	two hybrid	Rolland T (2014)	1
SEPHS1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
EPHB6	4	REL	5	two hybrid	Rolland T (2014)	1
REL	5	EIF3D	0	two hybrid	Rolland T (2014)	1
SAT1	0	SNAI2	0	two hybrid	Rolland T (2014)	1
SAT1	0	FAM156A	0	two hybrid	Rolland T (2014)	1
COPS6	0	RPLP1	0	affinity chromatography technology	Bennett EJ (2010)	1
SAT1	0	EVA1A	0	two hybrid	Stelzl U (2005)	1
SAT1	0	PLGRKT	0	two hybrid	Stelzl U (2005)	1
REL	5	DMRT3	2	two hybrid	Rolland T (2014)	1
CASP7	1	SAT1	0	two hybrid	Rolland T (2014)	1
SAT1	0	RBM17	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
SAT1	0	HSPE1	0	two hybrid	Stelzl U (2005)	1
SAT1	0	PTN	0	two hybrid	Stelzl U (2005)	1
KAT5	1	RELA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Kim JW (2012), Kim JW (2012), Kim JW (2012)	3
TP53	0	VASP	0	affinity chromatography technology	Fogeron ML (2013)	1
SAT1	0	TACO1	1	two hybrid	Rual JF (2005)	1
REL	5	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Hansen SK (1994), Hansen SK (1994), Liss AS (2002), Liss AS (2002), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	8
SAT1	0	EIF3D	0	two hybrid	Rolland T (2014)	1
HIF1A	1	SAT2	0	pull down, affinity chromatography technology	Baek JH (2007), Baek JH (2007)	2
TSC22D4	1	LNX1	7	two hybrid	Rual JF (2005)	1
SAT1	0	DGKZ	6	two hybrid	Stelzl U (2005)	1
VASP	0	SAT1	0	two hybrid	Venkatesan K (2009)	1
APLP1	1	UTP14A	0	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
SAT1	0	CCDC90B	2	two hybrid	Stelzl U (2005)	1
SAT1	0	FTSJ3	2	two hybrid	Rual JF (2005)	1
NIF3L1	0	TSC22D4	1	two hybrid	Rual JF (2005)	1
SAT1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
SAT1	0	LNX1	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NIF3L1	0	SAT1	0	two hybrid	Venkatesan K (2009)	1
SEPHS1	0	GBP2	0	two hybrid	Stelzl U (2005)	1
SAT1	0	SEPHS1	0	two hybrid	Stelzl U (2005)	1
SAT1	0	TSC22D4	1	two hybrid	Rual JF (2005)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
LUC7L2	0	CEP126	0	two hybrid	Stelzl U (2005)	1
SAT1	0	NMRK2	2	two hybrid	Stelzl U (2005)	1
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
HSPE1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
EEF1G	0	PLGRKT	0	two hybrid	Rolland T (2014)	1
SAT1	0	CHD3	19	two hybrid	Stelzl U (2005)	1
REL	5	SAT1	0	two hybrid	Rolland T (2014)	1
SEPHS1	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
HSPE1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
CHD3	19	LRIF1	3	two hybrid	Goehler H (2004)	1
CASP7	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
HSPE1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
SEPHS1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
SAT1	0	UNC119	4	two hybrid	Stelzl U (2005)	1
RACK1	2	SAT1	0	pull down	Baek JH (2007)	1
APLP1	1	SETDB1	3	two hybrid	Goehler H (2004)	1
RELA	1	SAT1	0	two hybrid	Wang J (2011)	1
APLP1	1	LRIF1	3	two hybrid	Goehler H (2004)	1
SAT1	0	KAT7	3	two hybrid	Stelzl U (2005)	1
SAT1	0	FAM86C1	3	two hybrid	Rual JF (2005)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
RACK1	2	PTN	0	two hybrid	Stelzl U (2005)	1
LNX1	7	KCNA4	5	affinity chromatography technology, two hybrid, enzymatic study	Wolting CD (2011), Guo Z (2012), Guo Z (2012)	3
PTN	0	CHD3	19	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
SAT1	0	C19orf25	0	two hybrid	Rolland T (2014)	1
SAT1	0	TUBB2A	2	two hybrid	Stelzl U (2005)	1
SAT1	0	DNPEP	2	two hybrid	Rual JF (2005)	1
SAT1	0	KAT5	1	two hybrid	Stelzl U (2005)	1
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
SAT1	0	CCHCR1	2	two hybrid	Rolland T (2014)	1
RPLP1	0	PTN	0	two hybrid	Stelzl U (2005)	1
SAT1	0	SARAF	0	two hybrid	Stelzl U (2005)	1
SAT1	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
HIF1A	1	SAT1	0	pull down	Baek JH (2007)	1
EPHB6	4	NIF3L1	0	two hybrid	Rolland T (2014)	1
SAT1	0	TLE1	6	two hybrid	Stelzl U (2005)	1
LUC7L2	0	UNC119	4	two hybrid	Stelzl U (2005)	1
DNPEP	2	LNX1	7	two hybrid	Rolland T (2014)	1
SAT1	0	FUNDC2	0	two hybrid	Stelzl U (2005)	1
SAT1	0	TP53	0	two hybrid	Stelzl U (2005)	1
SAT1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
SAT1	0	APLP1	1	two hybrid	Stelzl U (2005)	1
SAT1	0	MTA1	3	two hybrid	Rolland T (2014)	1
SETDB1	3	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
HOXB6	0	SAT1	0	two hybrid	Rual JF (2005)	1
SAT1	0	KCNA4	5	two hybrid	Stelzl U (2005)	1
SAT1	0	ABCB8	3	two hybrid	Stelzl U (2005)	1
KAT5	1	LRIF1	3	two hybrid	Goehler H (2004)	1
SAT1	0	SAT2	0	two hybrid	Rual JF (2005)	1
APLP1	1	GDF9	2	two hybrid	Goehler H (2004)	1
JUNB	0	SAT1	0	two hybrid	Wang J (2011)	1
HSPE1	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3
RPLP1	0	TUBB2A	2	two hybrid	Stelzl U (2005)	1
SAT1	0	UTP14A	0	two hybrid	Stelzl U (2005)	1
HSPE1	0	GBP2	0	two hybrid	Stelzl U (2005)	1
HSPB1	2	MED31	0	two hybrid	Stelzl U (2005)	1