Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SCN2A 6326 LAMOTRIGINE CHEMBL741 inhibitor, blocker PharmGKB, TdgClinicalTrial, ChemblInteractions, DrugBank 17139284, 17016423, 16174788
SCN2A 6326 OXCARBAZEPINE CHEMBL1068 blocker PharmGKB, ChemblInteractions
SCN2A 6326 CHEMBL270497 CHEMBL270497 gating inhibitor GuideToPharmacologyInteractions
SCN2A 6326 TOPIRAMATE CHEMBL220492 blocker PharmGKB, ChemblInteractions
SCN2A 6326 PHENACEMIDE CHEMBL918 blocker ChemblInteractions
SCN2A 6326 PRIMIDONE CHEMBL856 blocker ChemblInteractions
SCN2A 6326 DYCLONINE HYDROCHLORIDE CHEMBL1200478 blocker ChemblInteractions
SCN2A 6326 MERETHOXYLLINE PROCAINE CHEMBL1200443 blocker ChemblInteractions
SCN2A 6326 ETIDOCAINE HYDROCHLORIDE CHEMBL1200597 blocker ChemblInteractions
SCN2A 6326 NKTR-171 CHEMBL3545209 blocker ChemblInteractions
SCN2A 6326 IRAMPANEL CHEMBL29741 blocker ChemblInteractions
SCN2A 6326 RALFINAMIDE CHEMBL2107771 blocker ChemblInteractions
SCN2A 6326 MEPHENYTOIN CHEMBL861 blocker ChemblInteractions
SCN2A 6326 ARTICAINE HYDROCHLORIDE CHEMBL1200819 blocker ChemblInteractions
SCN2A 6326 ORPHENADRINE CITRATE CHEMBL1200395 blocker ChemblInteractions
SCN2A 6326 TETRACAINE CHEMBL698 blocker ChemblInteractions
SCN2A 6326 QUINIDINE GLUCONATE CHEMBL1200437 blocker ChemblInteractions
SCN2A 6326 PHENAZOPYRIDINE HYDROCHLORIDE CHEMBL1201022 blocker ChemblInteractions
SCN2A 6326 PROPOXYCAINE HYDROCHLORIDE CHEMBL1769 blocker ChemblInteractions
SCN2A 6326 LIDOCAINE HYDROCHLORIDE HYDRATE CHEMBL1200409 blocker ChemblInteractions
SCN2A 6326 FOSPROPOFOL CHEMBL1201766 TEND
SCN2A 6326 ROPIVACAINE HYDROCHLORIDE CHEMBL1889140 blocker ChemblInteractions
SCN2A 6326 BENOXINATE HYDROCHLORIDE CHEMBL1200654 blocker ChemblInteractions
SCN2A 6326 HEXYLCAINE HYDROCHLORIDE CHEMBL1200715 blocker ChemblInteractions
SCN2A 6326 ETHOTOIN CHEMBL1095 blocker ChemblInteractions
SCN2A 6326 ORPHENADRINE (CHLORIDE) CHEMBL1201023 blocker ChemblInteractions
SCN2A 6326 PRILOCAINE HYDROCHLORIDE CHEMBL1200586 blocker ChemblInteractions
SCN2A 6326 ELPETRIGINE CHEMBL29919 blocker ChemblInteractions
SCN2A 6326 ESLICARBAZEPINE CHEMBL315985 blocker ChemblInteractions
SCN2A 6326 PROPAFENONE HYDROCHLORIDE CHEMBL1201063 blocker ChemblInteractions
SCN2A 6326 PROPARACAINE HYDROCHLORIDE CHEMBL1200464 blocker ChemblInteractions
SCN2A 6326 NW-3509 CHEMBL3545207 blocker ChemblInteractions
SCN2A 6326 DRONEDARONE HYDROCHLORIDE CHEMBL1201729 blocker ChemblInteractions
SCN2A 6326 MEPIVACAINE HYDROCHLORIDE CHEMBL1200440 blocker ChemblInteractions
SCN2A 6326 FOSPHENYTOIN SODIUM CHEMBL919 blocker ChemblInteractions
SCN2A 6326 ZONISAMIDE CHEMBL750 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 19557119, 20025128, 20001433, 18433351, 14704463, 15511691, 19948168
SCN2A 6326 SAFINAMIDE CHEMBL396778 TdgClinicalTrial
SCN2A 6326 CARBAMAZEPINE CHEMBL108 blocker PharmGKB, ChemblInteractions
SCN2A 6326 RILUZOLE CHEMBL744 blocker ChemblInteractions
SCN2A 6326 DISOPYRAMIDE PHOSPHATE CHEMBL1201020 blocker ChemblInteractions
SCN2A 6326 QUINIDINE SULFATE CHEMBL3707183 blocker ChemblInteractions
SCN2A 6326 INDECAINIDE HYDROCHLORIDE CHEMBL1200341 blocker ChemblInteractions
SCN2A 6326 LIDOCAINE CHEMBL79 blocker ChemblInteractions
SCN2A 6326 TOCAINIDE HYDROCHLORIDE CHEMBL1200773 blocker ChemblInteractions
SCN2A 6326 NERISPIRDINE CHEMBL2107762 blocker ChemblInteractions
SCN2A 6326 PRILOCAINE CHEMBL1194 blocker ChemblInteractions
SCN2A 6326 CHLOROPROCAINE HYDROCHLORIDE CHEMBL944 blocker ChemblInteractions
SCN2A 6326 PROCAINE HYDROCHLORIDE CHEMBL1200841 blocker ChemblInteractions
SCN2A 6326 PROPOFOL CHEMBL526 inhibitor TdgClinicalTrial, TEND, DrugBank 18574460
SCN2A 6326 PHENYTOIN CHEMBL16 blocker, channel blocker GuideToPharmacologyInteractions, ChemblInteractions
SCN2A 6326 MEXILETINE HYDROCHLORIDE CHEMBL1200606 blocker ChemblInteractions
SCN2A 6326 PHENYTOIN SODIUM CHEMBL1611 blocker ChemblInteractions
SCN2A 6326 RUFINAMIDE CHEMBL1201754 blocker ChemblInteractions
SCN2A 6326 TETRACAINE HYDROCHLORIDE CHEMBL1255654 blocker ChemblInteractions
SCN2A 6326 LACOSAMIDE CHEMBL58323 blocker ChemblInteractions
SCN2A 6326 PROCAINAMIDE HYDROCHLORIDE CHEMBL605 blocker ChemblInteractions
SCN2A 6326 ESLICARBAZEPINE ACETATE CHEMBL87992 blocker ChemblInteractions
SCN2A 6326 QUINIDINE POLYGALACTURONATE CHEMBL1201486 blocker ChemblInteractions
SCN2A 6326 MORICIZINE HYDROCHLORIDE CHEMBL1200334 blocker ChemblInteractions
SCN2A 6326 TETRODOTOXIN CHEMBL507974 TdgClinicalTrial, DrugBank 17663442

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SCN2A rs17183814 A carbamazepine "dosage","metabolism/PK" no and not associated with In concentration/dose ratio. Allele A is not associated with increased dose of carbamazepine in people with Epilepsy as compared to allele G. 22188362 827824060
SCN2A rs17183814 A carbamazepine efficacy yes p value was above significance level after correction for multiple testing. Authors note that association was found at the allele level but not at the genotype level, and that this may be due to a low number of AA individuals. Allele A is associated with resistance to carbamazepine, phenobarbital, phenytoin or valproic acid as compared to allele G. 19694741 981751120
SCN2A rs17183814 A carbamazepine efficacy no No significant association was found with this SNP and response to epilepsy drugs. Allele A is not associated with response to carbamazepine or valproic acid in people with Epilepsy as compared to allele G. 23859570 1183613417
SCN2A rs2304016 GG carbamazepine efficacy no Genotypes of this SNP did not have significantly different frequencies in the drug resistant patients compared to drug responsive patients. Alleles have been complemented to the plus chromosomal strand. Variant described as SCN2A IVS7-32A>G. Genotype GG is not associated with resistance to carbamazepine or oxcarbazepine in people with Epilepsy as compared to genotype AA. 25155934 1184999851
SCN2A rs17183814 A carbamazepine efficacy no No significant association was found with this SNP and response to epilepsy drugs after 1000 permutation testing for each marker or haplotype and Bonferroni correction. Allele A is not associated with response to carbamazepine or valproic acid in people with Epilepsy as compared to allele G. 23859570 1183614112
SCN2A rs17183814 AA carbamazepine efficacy no Genotypes of this SNP did not have significantly different frequencies in the drug resistant patients compared to drug responsive patients. Variant described as SCN2A c.56G>A. Genotype AA is not associated with resistance to carbamazepine or oxcarbazepine in people with Epilepsy as compared to genotype GG. 25155934 1184999842