Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SCN4A 6329 HEXYLCAINE HYDROCHLORIDE CHEMBL1200715 blocker ChemblInteractions
SCN4A 6329 TOPIRAMATE CHEMBL220492 blocker ChemblInteractions
SCN4A 6329 ETIDOCAINE HYDROCHLORIDE CHEMBL1200597 blocker ChemblInteractions
SCN4A 6329 PROCAINAMIDE HYDROCHLORIDE CHEMBL605 blocker ChemblInteractions
SCN4A 6329 PROPOFOL CHEMBL526 inhibitor TdgClinicalTrial, TEND, DrugBank 18574460
SCN4A 6329 CHEMBL1331919 CHEMBL1331919 channel blocker GuideToPharmacologyInteractions
SCN4A 6329 RILUZOLE CHEMBL744 blocker ChemblInteractions
SCN4A 6329 PHENAZOPYRIDINE HYDROCHLORIDE CHEMBL1201022 blocker ChemblInteractions
SCN4A 6329 DISOPYRAMIDE PHOSPHATE CHEMBL1201020 blocker ChemblInteractions
SCN4A 6329 PRILOCAINE CHEMBL1194 blocker ChemblInteractions
SCN4A 6329 IRAMPANEL CHEMBL29741 blocker ChemblInteractions
SCN4A 6329 LACOSAMIDE CHEMBL58323 blocker ChemblInteractions
SCN4A 6329 NKTR-171 CHEMBL3545209 blocker ChemblInteractions
SCN4A 6329 ARTICAINE HYDROCHLORIDE CHEMBL1200819 blocker ChemblInteractions
SCN4A 6329 TETRACAINE CHEMBL698 blocker ChemblInteractions
SCN4A 6329 MEPHENYTOIN CHEMBL861 blocker ChemblInteractions
SCN4A 6329 FOSPROPOFOL CHEMBL1201766 TEND
SCN4A 6329 TETRACAINE HYDROCHLORIDE CHEMBL1255654 blocker ChemblInteractions
SCN4A 6329 LIDOCAINE HYDROCHLORIDE HYDRATE CHEMBL1200409 blocker ChemblInteractions
SCN4A 6329 PHENACEMIDE CHEMBL918 blocker ChemblInteractions
SCN4A 6329 BENOXINATE HYDROCHLORIDE CHEMBL1200654 blocker ChemblInteractions
SCN4A 6329 PRIMIDONE CHEMBL856 blocker ChemblInteractions
SCN4A 6329 ETHOTOIN CHEMBL1095 blocker ChemblInteractions
SCN4A 6329 MERETHOXYLLINE PROCAINE CHEMBL1200443 blocker ChemblInteractions
SCN4A 6329 ORPHENADRINE (CHLORIDE) CHEMBL1201023 blocker ChemblInteractions
SCN4A 6329 ORPHENADRINE CITRATE CHEMBL1200395 blocker ChemblInteractions
SCN4A 6329 LAMOTRIGINE CHEMBL741 blocker ChemblInteractions
SCN4A 6329 LEVOBUPIVACAINE HYDROCHLORIDE CHEMBL1200749 blocker ChemblInteractions
SCN4A 6329 BUPIVACAINE CHEMBL1098 blocker ChemblInteractions
SCN4A 6329 RANOLAZINE CHEMBL1404 blocker ChemblInteractions
SCN4A 6329 OXCARBAZEPINE CHEMBL1068 blocker ChemblInteractions
SCN4A 6329 ESLICARBAZEPINE ACETATE CHEMBL87992 blocker ChemblInteractions
SCN4A 6329 NW-3509 CHEMBL3545207 blocker ChemblInteractions
SCN4A 6329 PROPOXYCAINE HYDROCHLORIDE CHEMBL1769 blocker ChemblInteractions
SCN4A 6329 PROPARACAINE HYDROCHLORIDE CHEMBL1200464 blocker ChemblInteractions
SCN4A 6329 DRONEDARONE HYDROCHLORIDE CHEMBL1201729 blocker ChemblInteractions
SCN4A 6329 PRILOCAINE HYDROCHLORIDE CHEMBL1200586 blocker ChemblInteractions
SCN4A 6329 RALFINAMIDE CHEMBL2107771 blocker ChemblInteractions
SCN4A 6329 MORICIZINE HYDROCHLORIDE CHEMBL1200334 blocker ChemblInteractions
SCN4A 6329 PROPAFENONE HYDROCHLORIDE CHEMBL1201063 blocker ChemblInteractions
SCN4A 6329 ZONISAMIDE CHEMBL750 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 19557119, 20025128, 20001433, 18433351, 14704463, 15511691, 19948168
SCN4A 6329 CHEMBL270497 CHEMBL270497 gating inhibitor GuideToPharmacologyInteractions
SCN4A 6329 PHENYTOIN CHEMBL16 blocker ChemblInteractions
SCN4A 6329 INDECAINIDE HYDROCHLORIDE CHEMBL1200341 blocker ChemblInteractions
SCN4A 6329 LIDOCAINE CHEMBL79 blocker ChemblInteractions
SCN4A 6329 ESLICARBAZEPINE CHEMBL315985 blocker ChemblInteractions
SCN4A 6329 BUPIVACAINE HYDROCHLORIDE CHEMBL1200396 blocker ChemblInteractions
SCN4A 6329 MEXILETINE HYDROCHLORIDE CHEMBL1200606 blocker ChemblInteractions
SCN4A 6329 PHENYTOIN SODIUM CHEMBL1611 blocker ChemblInteractions
SCN4A 6329 RUFINAMIDE CHEMBL1201754 blocker ChemblInteractions
SCN4A 6329 MEXILETINE CHEMBL558 channel blocker GuideToPharmacologyInteractions
SCN4A 6329 TETRODOTOXIN CHEMBL507974 channel blocker TdgClinicalTrial, GuideToPharmacologyInteractions
SCN4A 6329 ROPIVACAINE HYDROCHLORIDE CHEMBL1889140 blocker ChemblInteractions
SCN4A 6329 CHLOROPROCAINE HYDROCHLORIDE CHEMBL944 blocker ChemblInteractions
SCN4A 6329 QUINIDINE GLUCONATE CHEMBL1200437 blocker ChemblInteractions
SCN4A 6329 QUINIDINE SULFATE CHEMBL3707183 blocker ChemblInteractions
SCN4A 6329 PROCAINE HYDROCHLORIDE CHEMBL1200841 blocker ChemblInteractions
SCN4A 6329 CARBAMAZEPINE CHEMBL108 blocker ChemblInteractions
SCN4A 6329 NERISPIRDINE CHEMBL2107762 blocker ChemblInteractions
SCN4A 6329 DYCLONINE HYDROCHLORIDE CHEMBL1200478 blocker ChemblInteractions
SCN4A 6329 TOCAINIDE HYDROCHLORIDE CHEMBL1200773 blocker ChemblInteractions
SCN4A 6329 QUINIDINE POLYGALACTURONATE CHEMBL1201486 blocker ChemblInteractions
SCN4A 6329 MEPIVACAINE HYDROCHLORIDE CHEMBL1200440 blocker ChemblInteractions
SCN4A 6329 FOSPHENYTOIN SODIUM CHEMBL919 blocker ChemblInteractions
SCN4A 6329 SAFINAMIDE CHEMBL396778 TdgClinicalTrial
SCN4A 6329 FLECAINIDE CHEMBL652 inhibitor DrugBank 14608015

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SCN4A rs80338792 T flecainide efficacy not stated This case study showed two patients (mother and son) who both had the same genetic variant (presented in the paper as SCN4A G1306E) causing myotonia permanens. After years of poor response to mexiletine, patients were switched to flecainide and saw huge improvements. This suggests that patients with this myotonia permanens causing variation may benefit more from treatment with flecainide than mexilitine. Allele T is associated with increased response to flecainide in people with Myotonia as compared to allele C. 23052413 1183682419