PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SCNN1B	1	NEDD4L	3	far western blotting, far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Harvey KF (2001), Rauh R (2006), Soundararajan R (2009), Itani OA (2003), Snyder PM (2004), Bhalla V (2006), Lott JS (2002), Itani OA (2005)	8
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
SCNN1B	1	USP8	7	affinity chromatography technology, affinity chromatography technology	Zhou R (2013), Zhou R (2013)	2
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
SNX3	1	USP10	2	pull down	Boulkroun S (2008)	1
SCNN1B	1	ITCH	1	far western blotting	Harvey KF (2001)	1
CSNK2A1	15	SCNN1A	1	enzymatic study	Edinger RS (2009)	1
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
SNX3	1	SCNN1A	1	affinity chromatography technology	Boulkroun S (2008)	1
SCNN1A	1	UBE2I	0	two hybrid	Malbert-Colas L (2003)	1
SCNN1A	1	SCNN1G	2	affinity chromatography technology	Buck TM (2017)	1
STX1A	2	SCNN1A	1	affinity chromatography technology	Berdiev BK (2004)	1
HNRNPL	3	WWP1	3	affinity chromatography technology	Fei T (2017)	1
SCNN1B	1	HGS	5	affinity chromatography technology	Zhou R (2010)	1
SCNN1A	1	HYOU1	2	affinity chromatography technology	Buck TM (2013)	1
USP2	0	SCNN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberfeld B (2011), Ruffieux-Daidie D (2008), Ruffieux-Daidie D (2008)	3
SCNN1G	2	EPN1	4	affinity chromatography technology, pull down	Wang H (2006), Wang H (2006)	2
SCNN1G	2	NEDD4	2	pull down, pull down, far western blotting, enzymatic study, affinity chromatography technology	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Woelk T (2006), Snyder PM (2001)	5
HUWE1	22	SCNN1A	1	affinity chromatography technology	You H (2017)	1
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
SCNN1B	1	EPN1	4	affinity chromatography technology, pull down	Wang H (2006), Wang H (2006)	2
HNRNPL	3	SCNN1A	1	affinity chromatography technology	Fei T (2017)	1
WWP2	7	SCNN1A	1	pull down	McDonald FJ (2002)	1
STX1A	2	SCNN1G	2	affinity chromatography technology, pull down	Berdiev BK (2004), Berdiev BK (2004)	2
DERL1	2	SCNN1A	1	affinity chromatography technology, affinity chromatography technology	You H (2017), You H (2017)	2
USP2	0	SCNN1G	2	affinity chromatography technology, affinity chromatography technology	Oberfeld B (2011), Ruffieux-Daidie D (2008)	2
SCNN1A	1	EPN1	4	affinity chromatography technology, pull down	Wang H (2006), Wang H (2006)	2
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
WWP2	7	SCNN1G	2	pull down	McDonald FJ (2002)	1
SCNN1B	1	SCNN1G	2	protein complementation assay	Faria D (2012)	1
SCNN1B	1	USP2	0	affinity chromatography technology	Ruffieux-Daidie D (2008)	1
HGS	5	SNX3	1	biochemical	Wan C (2015)	1
SCNN1A	1	NEDD4L	3	far western blotting, two hybrid, affinity chromatography technology, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Harvey KF (2001), Malbert-Colas L (2003), Zhou R (2007), Rauh R (2006), Itani OA (2003), Snyder PM (2004), Bhalla V (2006), Lott JS (2002), Ruffieux-Daidie D (2008), Xu D (2015)	10
SCNN1A	1	WWP1	3	two hybrid	Malbert-Colas L (2003)	1
NEDD4L	3	HGS	5	enzymatic study, affinity chromatography technology	Persaud A (2009), Zhou R (2010)	2
TSG101	1	HGS	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, unspecified method, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Rual JF (2005), Lu Q (2003), Lu Q (2003), Lu Q (2003), Kim BY (2007), Im YJ (2010), Schlundt A (2009), Schlundt A (2009), Pornillos O (2003), Pornillos O (2003), Bache KG (2003), Bache KG (2003), Bouamr F (2007), Kim HJ (2007), Kumar B (2016), Kumar B (2016)	16
UBE2I	0	HGS	5	two hybrid	Rual JF (2005)	1
SCNN1B	1	NEDD4	2	pull down, pull down, far western blotting, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Persaud A (2009), Ke Y (2010), Snyder PM (2001), Kanelis V (2001)	7
UBE2I	0	WWP2	7	enzymatic study	Bawa-Khalfe T (2016)	1
AP1M2	2	SCNN1B	1	affinity chromatography technology	Wang H (2006)	1
SCNN1A	1	ITCH	1	far western blotting	Harvey KF (2001)	1
AP1M2	2	SCNN1A	1	affinity chromatography technology	Wang H (2006)	1
HNRNPL	3	WWP2	7	affinity chromatography technology	Fei T (2017)	1
SCNN1A	1	HGS	5	affinity chromatography technology, affinity chromatography technology	Zhou R (2010), Zhou R (2010)	2
HNRNPL	3	USP10	2	affinity chromatography technology	Fei T (2017)	1
SCNN1A	1	SERP1	0	protein complementation assay	Faria D (2012)	1
WWP2	7	SCNN1B	1	pull down, far western blotting	McDonald FJ (2002), Harvey KF (2001)	2
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
DERL1	2	HUWE1	22	affinity chromatography technology	You H (2017)	1
HNRNPL	3	HUWE1	22	affinity chromatography technology	Fei T (2017)	1
USP8	7	SCNN1G	2	affinity chromatography technology	Zhou R (2013)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
STX1A	2	SCNN1B	1	affinity chromatography technology	Berdiev BK (2004)	1
SCNN1A	1	TSG101	1	two hybrid	Malbert-Colas L (2003)	1
SCNN1A	1	NEDD4	2	pull down, pull down, far western blotting, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Snyder PM (2001), Bobby R (2013), Panwalkar V (2016), Panwalkar V (2016)	7
UBE2I	0	USP8	7	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
AP1M2	2	SCNN1G	2	affinity chromatography technology	Wiemuth D (2007)	1
TSG101	1	UBE2I	0	biochemical	Wan C (2015)	1
SCNN1G	2	NEDD4L	3	far western blotting, unspecified method, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method	Harvey KF (2001), Nagaki K (2006), Rauh R (2006), Itani OA (2003), Snyder PM (2004), Bhalla V (2006), Lott JS (2002)	7
EPN1	4	AP1M2	2	affinity chromatography technology	Wang H (2006)	1
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
SCNN1G	2	SERP1	0	protein complementation assay	Faria D (2012)	1
SCNN1A	1	USP8	7	affinity chromatography technology	Zhou R (2013)	1
SCNN1B	1	HECW1	3	far western blotting	Harvey KF (2001)	1
SCNN1A	1	HECW1	3	far western blotting	Harvey KF (2001)	1
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
HNRNPL	3	NEDD4L	3	affinity chromatography technology	Fei T (2017)	1
SCNN1B	1	SERP1	0	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012)	3
USP10	2	SCNN1A	1	affinity chromatography technology	Boulkroun S (2008)	1
CSNK2A1	15	ITCH	1	enzymatic study	Morales B (2007)	1
NEDD4	2	HNRNPL	3	pull down	Ingham RJ (2005)	1