PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP7	14	CLSPN	1	affinity chromatography technology, enzymatic study	Faustrup H (2009), Faustrup H (2009)	2
CASP7	1	CLSPN	1	enzymatic study	Clarke CA (2005)	1
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
GINS3	1	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PMS2	4	MSH6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Matton N (2000), Matton N (2000), Plotz G (2003)	4
CDK9	3	ATR	6	affinity chromatography technology	Yu DS (2010)	1
PCNA	0	RAD9A	1	affinity chromatography technology	Dahm K (2002)	1
EGLN3	0	MSH6	2	affinity chromatography technology	Rodriguez J (2016)	1
GJB2	1	CLSPN	1	affinity chromatography technology	Hein MY (2015)	1
CDK9	3	CHEK1	2	genetic interference	Shen JP (2017)	1
PMS2	4	PCNA	0	affinity chromatography technology, far western blotting, pull down	Cannavo E (2007), Dzantiev L (2004), Genschel J (2017)	3
PCNA	0	CHEK1	2	affinity chromatography technology	Scorah J (2008)	1
XPO1	8	CDC20	1	affinity chromatography technology	Kirli K (2015)	1
RAD9A	1	RAD17	2	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Bermudez VP (2003), Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Lindsey-Boltz LA (2001), Zhang L (2010)	7
CLSPN	1	HERC2	9	affinity chromatography technology, affinity chromatography technology	Izawa N (2011), Zhu M (2014)	2
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
ATR	6	CLSPN	1	affinity chromatography technology	Chini CC (2003)	1
BRCA1	7	HERC2	9	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wu W (2010), Wu W (2010), Wu W (2010), Peng Y (2015)	4
USP20	3	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Galligan JT (2015), Yuan J (2014), Yuan J (2014), Yuan J (2014), Zhu M (2014), Zhu M (2014)	7
RAD9A	1	MSH6	2	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
CLSPN	1	PCNA	0	affinity chromatography technology	Yang XH (2008)	1
ATR	6	USP20	3	affinity chromatography technology	Zhu M (2014)	1
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
CLSPN	1	HUS1	1	genetic interference	Horlbeck MA (2018)	1
CLSPN	1	CDC7	2	affinity chromatography technology, pull down	Kim JM (2008), Kim JM (2008)	2
CDC20	1	PCNA	0	affinity chromatography technology	Craney A (2016)	1
CHEK1	2	RAD17	2	genetic interference	Srivas R (2016)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
RAD17	2	HUS1	1	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Huttlin EL (2015), Huttlin EL (2017)	5
RAD17	2	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Wang X (2006)	2
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
USP20	3	CLSPN	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yuan J (2014), Yuan J (2014), Yuan J (2014), Yuan J (2014), Zhu M (2014), Zhu M (2014), Zhu M (2014)	7
USP29	2	CLSPN	1	affinity chromatography technology, enzymatic study	Martin Y (2014), Martin Y (2014)	2
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
MSH6	2	CHEK1	2	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
CEP250	4	CLSPN	1	affinity chromatography technology	Fogeron ML (2013)	1
USP20	3	RAD17	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sowa ME (2009), Shanmugam I (2014), Shanmugam I (2014), Shanmugam I (2014)	4
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
RAD9A	1	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Chini CC (2003), Zhang L (2010)	2
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
EGLN3	0	CDC20	1	affinity chromatography technology	Rodriguez J (2016)	1
BRCA1	7	PMS2	4	affinity chromatography technology	Hill SJ (2014)	1
CDC20	1	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Sedgwick GG (2012), Hyun SY (2013), Hyun SY (2013), Hyun SY (2013), Jia L (2016)	5
CDC7	2	CDK9	3	two hybrid	Wang J (2011)	1
EGLN3	0	PCNA	0	affinity chromatography technology	Rodriguez J (2016)	1
CLSPN	1	PLK1	0	affinity chromatography technology, affinity chromatography technology	Peschiaroli A (2006), Mailand N (2006)	2
CDC20	1	CLSPN	1	affinity chromatography technology	Gao D (2009)	1
MPP1	1	CLSPN	1	affinity chromatography technology	Hein MY (2015)	1
GINS3	1	TIMELESS	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LTN1	8	CLSPN	1	affinity chromatography technology	Hein MY (2015)	1
PMS2	4	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
BTRC	1	CLSPN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peschiaroli A (2006), Mailand N (2006), Peschiaroli A (2006), Gao D (2009), Bassermann F (2008), Kee Y (2009)	6
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
HUS1	1	PCNA	0	two hybrid, two hybrid, affinity chromatography technology	Komatsu K (2000), Komatsu K (2000), Komatsu K (2000)	3
USP28	3	USP20	3	enzymatic study	Loch CM (2012)	1
EGLN3	0	PLK1	0	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	CLSPN	1	affinity chromatography technology	Kirli K (2015)	1
CHEK1	2	XPO1	8	pull down	Jiang K (2003)	1
TIMELESS	8	CHEK1	2	affinity chromatography technology	Unsal-Kacmaz K (2005)	1
EGLN3	0	BRCA1	7	affinity chromatography technology	Rodriguez J (2016)	1
MSH6	2	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, biochemical, affinity chromatography technology	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Jascur T (2011), Schoepf B (2012), Havugimana PC (2012), Dzantiev L (2004), Han J (2014), Wan C (2015), Hein MY (2015)	11
BRCA1	7	CDK9	3	two hybrid	Woods NT (2012)	1
ATR	6	RAD17	2	unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kim ST (1999), Bao S (2001), Bao S (2001), Bomgarden RD (2004), Zhang L (2010)	5
CHEK1	2	CLSPN	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Chini CC (2003), Chini CC (2003), Chini CC (2006), Chini CC (2006), Chini CC (2006), Huh J (2013), Clarke CA (2005), Clarke CA (2005)	8
CDK9	3	CLSPN	1	affinity chromatography technology	Yu DS (2010)	1
CLSPN	1	TIMELESS	8	affinity chromatography technology	Yang XH (2008)	1
FBXW11	2	CLSPN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peschiaroli A (2006), Gao D (2011), Bassermann F (2008), Kim TY (2014), Low TY (2014), Kee Y (2009)	6
USP28	3	CLSPN	1	affinity chromatography technology	Zhang D (2006)	1
BRCA1	7	MSH6	2	two hybrid, pull down, biochemical, affinity chromatography technology	Wang Q (2001), Wang Q (2001), Wang Y (2000), Hill SJ (2014)	4
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
TIMELESS	8	PCNA	0	affinity chromatography technology	Yang XH (2008)	1
EGLN3	0	CDK9	3	affinity chromatography technology	Rodriguez J (2016)	1
USP28	3	USP7	14	enzymatic study	Loch CM (2012)	1
EGLN3	0	CLSPN	1	affinity chromatography technology	Rodriguez J (2016)	1
HUS1	1	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
HUS1	1	MSH6	2	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
USP7	14	CHEK1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Qing P (2011), Zhang P (2014), Zhang P (2014), Tan X (2015), Alonso-de Vega I (2014)	5
ATR	6	RAD9A	1	affinity chromatography technology	Pabla N (2008)	1
FBXW11	2	CASP7	1	affinity chromatography technology	Low TY (2014)	1
MYH7	3	CLSPN	1	affinity chromatography technology	Hein MY (2015)	1
CLSPN	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lin SY (2004), Lin SY (2004), Sato K (2012)	3
USP20	3	PLK1	0	affinity chromatography technology	Sowa ME (2009)	1
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
CLSPN	1	LTA	1	affinity chromatography technology	Hein J (2009)	1
BTRC	1	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Fukushima H (2013)	3
CEP250	4	HERC2	9	affinity chromatography technology	Fogeron ML (2013)	1
MSH6	2	ATR	6	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
PMS2	4	XPO1	8	affinity chromatography technology	Cannavo E (2007)	1
RAD9A	1	HUS1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Dufault VM (2003), Volkmer E (1999), Volkmer E (1999), Griffith JD (2002), Hirai I (2002), Huttlin EL (2015), Huttlin EL (2017)	8
MSH6	2	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
XPO1	8	CDC7	2	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	CDC7	2	affinity chromatography technology	Rodriguez J (2016)	1
ATR	6	HUS1	1	affinity chromatography technology	Pabla N (2008)	1
ATR	6	BRCA1	7	pull down, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tibbetts RS (2000), Kim ST (1999), Mu JJ (2007), Chen J (2000), Chen J (2000), Tibbetts RS (2000), Gatei M (2001), Gatei M (2001), Gatei M (2001), Tian F (2013)	10
CDC20	1	BTRC	1	affinity chromatography technology	Guardavaccaro D (2008)	1
FZR1	1	CLSPN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Gao D (2009), Bassermann F (2008), Bassermann F (2008)	3