Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PRDM16 rs11807862 AA atorvastatin efficacy no There could be strand confusion with this A/T SNP. The result is reported as max effect with simvastatin = 51.7 +/- 33.87 mg/dl in subjects homozygous for the minor allele vs. 74.96 +/- 29.71 mg/dl in those homozygous for the major allele, and 71.66 +/- 32.43 mg/dl for heterozygotes. The gene is on the positive chromosomal strand and dbSNP lists T>A. This SNP was also found to be associated with simvastatin max effect, also not significantly so after correction for multiple testing. Genotype AA is associated with decreased response to atorvastatin, hmg coa reductase inhibitors or simvastatin as compared to genotype TT. 24096969 1183685341