PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXO7	1	CAMK1	4	enzymatic study	Teixeira FR (2016)	1
BCL2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu C (2011), Xu C (2011), Trisciuoglio D (2010)	3
ATP5A1	0	ATP5E	0	affinity chromatography technology	Floyd BJ (2016)	1
ATP5A1	0	ATP5I	0	biochemical, affinity chromatography technology	Wan C (2015), Floyd BJ (2016)	2
BLK	4	BCL2L1	0	pull down	Hegde R (1998)	1
EGFR	5	GAPDH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Foerster S (2013), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014)	5
EGFR	5	ATP5F1	0	affinity chromatography technology	Tong J (2014)	1
ATP5H	0	ATP5I	0	biochemical	Wan C (2015)	1
BLK	4	BCL2	0	pull down	Hegde R (1998)	1
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
EDEM2	3	BLK	4	affinity chromatography technology	Huttlin EL (2017)	1
ATP5A1	0	ATP5B	0	biochemical, two hybrid, biochemical, affinity chromatography technology	Havugimana PC (2012), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	4
ERBB2	6	STAT3	0	affinity chromatography technology, unspecified method	Ren Z (2002), Jones RB (2006)	2
ATP5D	0	ATP5J	0	biochemical	Wan C (2015)	1
ATP5L	0	ATP5I	0	biochemical	Wan C (2015)	1
SENP1	0	BLK	4	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HSP90B1	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Yao Z (2017)	3
ATP5L	0	ATP5F1	0	biochemical	Wan C (2015)	1
CYTIP	3	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
ATP5L	0	ATP5D	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ATP5B	0	ATP5L	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ATP5O	0	ATP5F1	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ATP5H	0	ATP5O	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HSP90AA1	7	EEF2	11	affinity chromatography technology	Falsone SF (2005)	1
BLK	4	ATP5A1	0	affinity chromatography technology	So J (2015)	1
CAMK1	4	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
HSP90AA1	7	STAT3	0	affinity chromatography technology	Sato N (2003)	1
APBB3	2	ERBB2	6	unspecified method	Jones RB (2006)	1
FBXO7	1	ERBB2	6	enzymatic study	Teixeira FR (2016)	1
STAT3	0	CBL	7	two hybrid	Grossmann A (2015)	1
ATP5D	0	ATP5C1	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
ATP5F1	0	ATP5D	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
BLK	4	ATP5H	0	affinity chromatography technology	So J (2015)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
ATP5L	0	ATP5H	0	biochemical	Wan C (2015)	1
ATP5D	0	ATP5J2	0	biochemical	Wan C (2015)	1
HSP90AA1	7	BLK	4	affinity chromatography technology	Taipale M (2012)	1
HSP90B1	3	ERBB2	6	affinity chromatography technology	Chavany C (1996)	1
ATP5E	0	ATP5I	0	biochemical	Wan C (2015)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
CYTIP	3	EDEM2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP5A1	0	ATP5C1	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Floyd BJ (2016)	3
ATP5B	0	ATP5O	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
ATP5F1	0	ATP5B	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
A4GNT	0	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
ATP5F1	0	ATP5A1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Floyd BJ (2016), Huttlin EL (2017)	4
FBXO7	1	ATP5C1	0	affinity chromatography technology, enzymatic study	Teixeira FR (2016), Teixeira FR (2016)	2
CD79B	0	ERBB2	6	affinity chromatography technology	Huttlin EL (2017)	1
ATP5L	0	ATP5O	0	biochemical	Wan C (2015)	1
GLRA2	4	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
ATP5A1	0	ATP5D	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
EGFR	5	ATP5A1	0	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013)	2
FBXO7	1	PHB2	1	affinity chromatography technology	Teixeira FR (2016)	1
ATP5A1	0	ATP5J2	0	biochemical	Wan C (2015)	1
EGFR	5	ATP5L	0	affinity chromatography technology	Tong J (2014)	1
BLK	4	ATP5L	0	affinity chromatography technology	So J (2015)	1
ATP5C1	0	EGFR	5	two hybrid, affinity chromatography technology	Stelzl U (2005), Tong J (2009)	2
ATP5A1	0	USMG5	0	affinity chromatography technology	Floyd BJ (2016)	1
ATP5A1	0	ATP5O	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Floyd BJ (2016)	3
ATP5B	0	ATPIF1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATP5J	0	ATP5O	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BLK	4	YBX3	0	affinity chromatography technology	So J (2015)	1
BLK	4	HSP90B1	3	affinity chromatography technology	So J (2015)	1
ATP5B	0	ATP5H	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ATP5F1	0	ATPIF1	0	affinity chromatography technology	Huttlin EL (2017)	1
BLK	4	ATP5F1	0	affinity chromatography technology	So J (2015)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
ATP5F1	0	ATP5C1	0	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
FBXO7	1	BLK	4	enzymatic study	Teixeira FR (2016)	1
GLYR1	3	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
BLK	4	ATP5E	0	affinity chromatography technology	So J (2015)	1
EGFR	5	BLK	4	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
CBL	7	BLK	4	affinity chromatography technology	Panchamoorthy G (1996)	1
CBL	7	ERBB2	6	pull down, affinity chromatography technology	Zhou P (2003), Bisaro B (2016)	2
SCGB1A1	0	BLK	4	affinity chromatography technology	Huttlin EL (2017)	1
BLK	4	ATP5J2	0	affinity chromatography technology	So J (2015)	1
ATP5E	0	ATP5J	0	biochemical	Wan C (2015)	1
ATP5B	0	ATP5J2	0	biochemical	Wan C (2015)	1
ATP5L	0	ATP5C1	0	biochemical	Wan C (2015)	1
BLK	4	PHB2	1	affinity chromatography technology	So J (2015)	1
ATP5O	0	ATP5D	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ATP5F1	0	ATP5J	0	affinity chromatography technology	Huttlin EL (2017)	1
ATP5H	0	ATP5D	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ATP5B	0	HSP90AA1	7	biochemical	Wan C (2015)	1
ATP5L	0	PHB2	1	biochemical	Wan C (2015)	1
UBE3A	4	BLK	4	pull down, pull down	Oda H (1999), Oda H (1999)	2
CD79A	2	CD79B	0	affinity chromatography technology, pull down	Schamel WW (2003), Pao LI (1998)	2
APBB3	2	BLK	4	affinity chromatography technology	Huttlin EL (2017)	1
BLK	4	GNG12	0	affinity chromatography technology	So J (2015)	1
HSP90AA1	7	GAPDH	0	affinity chromatography technology, biochemical	Falsone SF (2005), Wan C (2015)	2
ATP5D	0	ATP5I	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
EGFR	5	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Yuan ZL (2004), Olayioye MA (1999), Lo HW (2005), Lo HW (2005), Crovello CS (1998), Jaganathan S (2011), Jaganathan S (2011), Andl CD (2004), Lo HW (2010), Foerster S (2013), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), de la Iglesia N (2008), Fan QW (2013), Fan QW (2013)	18
BLK	4	ATP5I	0	affinity chromatography technology	So J (2015)	1
EGFR	5	PLCG2	11	unspecified method, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Petschnigg J (2014)	5
BLK	4	ATP5C1	0	affinity chromatography technology	So J (2015)	1
BLK	4	ATPIF1	0	affinity chromatography technology	So J (2015)	1
BLK	4	CD79B	0	affinity chromatography technology	Saouaf SJ (1995)	1
ATP5L	0	ATP5A1	0	biochemical	Wan C (2015)	1
CBL	7	GAPDH	0	affinity chromatography technology	Feshchenko EA (2004)	1
ATP5A1	0	ATP5J	0	affinity chromatography technology	Floyd BJ (2016)	1
ATP5O	0	ATP5I	0	biochemical	Wan C (2015)	1
SYCP3	1	BLK	4	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	ATP5A1	0	biochemical	Wan C (2015)	1
ATP5J	0	ATP5B	0	affinity chromatography technology, pull down, affinity chromatography technology	Osanai T (2005), Osanai T (2005), Huttlin EL (2017)	3
BLK	4	ANKRD54	0	affinity chromatography technology	So J (2015)	1
ATP5J	0	ATP5I	0	biochemical	Wan C (2015)	1
ERBB2	6	BLK	4	unspecified method	Jones RB (2006)	1
BLK	4	EFS	2	two hybrid	Rolland T (2014)	1
ERBB2	6	PLCG2	11	unspecified method, imaging technique	Jones RB (2006), Chen TC (2014)	2
BLK	4	EEF1E1	0	affinity chromatography technology	So J (2015)	1
BLK	4	STAT3	0	two hybrid	Rolland T (2014)	1
BLK	4	PLCG2	11	pull down	Pleiman CM (1993)	1
BLK	4	GAPDH	0	affinity chromatography technology	So J (2015)	1
BLK	4	ATP5D	0	affinity chromatography technology	So J (2015)	1
BLK	4	ATP5J	0	affinity chromatography technology	So J (2015)	1
ATP5F1	0	ATP5H	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
ATP5B	0	ATP5C1	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
BLK	4	SNRPD1	0	affinity chromatography technology	So J (2015)	1
ATP5J	0	ATP5J2	0	biochemical	Havugimana PC (2012)	1
RNASE3	0	BLK	4	affinity chromatography technology	Huttlin EL (2017)	1
ATP5C1	0	ATPIF1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATP5B	0	ATP5D	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
ATP5A1	0	ATP5H	0	biochemical, affinity chromatography technology	Wan C (2015), Floyd BJ (2016)	2
ATP5F1	0	ATP5I	0	biochemical	Wan C (2015)	1
ATP5E	0	ATP5D	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
HSP90B1	3	STAT3	0	affinity chromatography technology, imaging technique	Maruvada R (2008), Maruvada R (2008)	2
FAM217B	1	BLK	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP5B	0	ATP5I	0	biochemical	Wan C (2015)	1
BLK	4	CCDC33	3	two hybrid	Rolland T (2014)	1
BLK	4	ATP5B	0	affinity chromatography technology	So J (2015)	1
SLC30A4	2	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
FBXO7	1	GAPDH	0	enzymatic study	Teixeira FR (2016)	1
EGFR	5	SNRPD1	0	affinity chromatography technology	Foerster S (2013)	1
FBXO7	1	ATP5A1	0	affinity chromatography technology	Teixeira FR (2016)	1
BLK	4	ATP5O	0	affinity chromatography technology	So J (2015)	1
BLK	4	USMG5	0	affinity chromatography technology	So J (2015)	1
APBB3	2	EGFR	5	unspecified method	Jones RB (2006)	1
ATP5C1	0	ATP5O	0	biochemical	Wan C (2015)	1
BLK	4	CD79A	2	affinity chromatography technology	Saouaf SJ (1995)	1
BLK	4	EEF2	11	affinity chromatography technology	So J (2015)	1