PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAL1	0	EP300	36	affinity chromatography technology, pull down, pull down, enzymatic study, pull down, pull down	Huang S (1999), Huang S (1999), Huang S (1999), Huang S (2000), Huang S (2000), Qiu Y (2002)	6
MYOD1	0	EP300	36	pull down, genetic interference, pull down, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Lau P (1999), Sartorelli V (1997), Sartorelli V (1997), Sartorelli V (1997), Magenta A (2003), Serra C (2007), Jin W (2011), Yuan W (1996), Yuan W (1996)	9
EP300	36	TWIST1	0	affinity chromatography technology, pull down, pull down, genetic interference	Hamamori Y (1999), Hamamori Y (1999), Hamamori Y (1999), Hamamori Y (1999)	4
ELSPBP1	1	ELSPBP1	1	pull down	Deed RW (1997)	1
TWIST1	0	ELSPBP1	1	affinity chromatography technology	Fu J (2011)	1
ELSPBP1	1	OLIG2	2	affinity chromatography technology	Samanta J (2004)	1
PSMD9	0	ELSPBP1	1	pull down, unspecified method	Sangith N (2014), Sangith N (2014)	2
ELSPBP1	1	OLIG1	0	affinity chromatography technology	Samanta J (2004)	1
TAL1	0	ELSPBP1	1	pull down	Huang S (2000)	1
EP300	36	ELSPBP1	1	affinity chromatography technology	Furumatsu T (2010)	1
MYOD1	0	ELSPBP1	1	affinity chromatography technology, pull down	Philipot O (2010), Deed RW (1997)	2