PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RRAGD	1	MTOR	14	affinity chromatography technology	Sancak Y (2008)	1
RRAGD	1	RPTOR	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2008), Sancak Y (2008), Han JM (2012), Han JM (2012), Oshiro N (2014)	5
RRAGB	1	LAMTOR3	0	affinity chromatography technology	Sancak Y (2010)	1
TBC1D7	1	RRAGA	1	affinity chromatography technology	Cloutier P (2017)	1
WDR24	0	MIOS	3	affinity chromatography technology, affinity chromatography technology	Bar-Peled L (2013), Boldt K (2016)	2
LGALS9C	0	RRAGB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FPR2	1	SLC38A9	0	affinity chromatography technology	Huttlin EL (2017)	1
MIOS	3	RRAGA	1	affinity chromatography technology	Bar-Peled L (2013)	1
DEPDC5	1	RRAGA	1	affinity chromatography technology, affinity chromatography technology	Bar-Peled L (2013), Deng L (2015)	2
LGALS3	0	SQSTM1	0	imaging technique	Chen X (2014)	1
RRAGB	1	LAMTOR1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Wang S (2015)	3
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
RRAGC	3	TSC1	4	affinity chromatography technology	Demetriades C (2014)	1
LGALS9	0	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRAGB	1	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Wang S (2015)	3
LGALS8	4	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LGALS8	4	SLC38A9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAMTOR2	0	RPTOR	4	affinity chromatography technology	Sancak Y (2010)	1
LGALS8	4	RRAGB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LGALS3	0	RRAGB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SQSTM1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Linares JF (2015), Linares JF (2015)	3
TBC1D7	1	LAMTOR1	0	affinity chromatography technology	Cloutier P (2017)	1
RPTOR	4	RRAGC	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gong R (2011), Duran A (2011), Sancak Y (2008), Oshiro N (2014), Oshiro N (2014), Thomas JD (2014)	6
LAMTOR1	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Wang S (2015), Wang S (2015), Wang S (2015)	3
SQSTM1	0	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Duran A (2011), Duran A (2011)	2
LGALS9C	0	LGALS9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAMTOR1	0	LAMTOR3	0	biochemical	Havugimana PC (2012)	1
RRAGA	1	SLC38A9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Wang S (2015)	3
TSC2	17	RRAGB	1	affinity chromatography technology	Demetriades C (2014)	1
LAMTOR2	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology	Wang S (2015), Wang S (2015)	2
RRAGD	1	LAMTOR3	0	affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010)	2
RRAGC	3	WNT2	1	two hybrid	Wang J (2011)	1
LGALS9C	0	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
LAMTOR2	0	MTOR	14	affinity chromatography technology	Sancak Y (2010)	1
MPP3	0	RRAGC	3	two hybrid	Wang J (2011)	1
RRAGA	1	RRAGC	3	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Sekiguchi T (2001), Sekiguchi T (2001), Gong R (2011), Gong R (2011), Duran A (2011), Li L (2013), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Huttlin EL (2015), Deng L (2015), Huttlin EL (2017)	14
RRAGB	1	RRAGD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sancak Y (2008), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010)	6
TRAF6	0	RRAGC	3	affinity chromatography technology	Linares JF (2013)	1
WDR24	0	RRAGC	3	affinity chromatography technology	Bar-Peled L (2013)	1
RRAGD	1	LAMTOR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Han JM (2012), Sancak Y (2010), Sancak Y (2010)	3
TBC1D7	1	TSC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima A (2007), Nakashima A (2007), Nakashima A (2007), Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
RRAGB	1	MTOR	14	affinity chromatography technology, pull down	Oshiro N (2014), Oshiro N (2014)	2
TBC1D7	1	RRAGC	3	affinity chromatography technology	Cloutier P (2017)	1
TBC1D7	1	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima A (2007), Nakashima A (2007), Nakashima A (2007), Huttlin EL (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
FPR2	1	RRAGC	3	affinity chromatography technology	Huttlin EL (2017)	1
LAMTOR2	0	LAMTOR3	0	two hybrid, pull down, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Wunderlich W (2001), Wunderlich W (2001), Wunderlich W (2001), Havugimana PC (2012), Wang J (2011), Rolland T (2014), Sancak Y (2010), Yu H (2011)	8
WDR24	0	RRAGB	1	affinity chromatography technology	Bar-Peled L (2013)	1
TSC2	17	RRAGA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Demetriades C (2014), Demetriades C (2014), Deng L (2015)	3
DEPDC5	1	RRAGC	3	affinity chromatography technology, pull down	Bar-Peled L (2013), Bar-Peled L (2013)	2
TSC2	17	RRAGD	1	affinity chromatography technology	Demetriades C (2014)	1
LGALS3	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAMTOR1	0	LAMTOR2	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Sancak Y (2010), Wang S (2015)	3
NOL8	2	RRAGA	1	affinity chromatography technology, two hybrid	Sekiguchi T (2004), Sekiguchi T (2004)	2
RPTOR	4	RRAGA	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gong R (2011), Gong R (2011), Sancak Y (2008), Li L (2013), Oshiro N (2014), Huttlin EL (2015), Huttlin EL (2017)	7
TRAF6	0	RPTOR	4	affinity chromatography technology	Linares JF (2013)	1
LGALS9C	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPTOR	4	RRAGB	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Duran A (2011), Sancak Y (2008), Sancak Y (2008), Oshiro N (2014), Oshiro N (2014), Oshiro N (2014)	6
TRAF6	0	MTOR	14	affinity chromatography technology, enzymatic study	Linares JF (2013), Linares JF (2013)	2
RRAGC	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Duran A (2011), Oshiro N (2014)	2
LGALS9	0	LGALS3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1L	0	RRAGC	3	two hybrid	Lim J (2006)	1
LGALS9	0	SLC38A9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRAGC	3	LAMTOR1	0	affinity chromatography technology, affinity chromatography technology	Han JM (2012), Sancak Y (2010)	2
SQSTM1	0	RRAGB	1	affinity chromatography technology	Duran A (2011)	1
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
RRAGB	1	RRAGC	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Duran A (2011), Han JM (2012), Oshiro N (2014), Oshiro N (2014), Oshiro N (2014), Sancak Y (2010), Wang S (2015)	8
DEPDC5	1	RRAGB	1	pull down	Bar-Peled L (2013)	1
RRAGC	3	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Wang S (2015)	3
LAMTOR2	0	RRAGA	1	affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Wang S (2015)	2
TSC2	17	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Demetriades C (2014), Demetriades C (2014)	2
RRAGD	1	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Oshiro N (2014), Oshiro N (2014)	2
LGALS9C	0	LGALS3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SQSTM1	0	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Duran A (2011), Linares JF (2015)	3
WDR24	0	DEPDC5	1	affinity chromatography technology	Bar-Peled L (2013)	1
NOL8	2	RRAGD	1	affinity chromatography technology	Sekiguchi T (2004)	1
LGALS9	0	RRAGB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRAGC	3	LAMTOR3	0	affinity chromatography technology	Sancak Y (2010)	1
SLC38A9	0	RRAGC	3	affinity chromatography technology	Wang S (2015)	1
FPR2	1	RRAGB	1	affinity chromatography technology	Huttlin EL (2017)	1
RRAGB	1	SLC38A9	0	affinity chromatography technology	Wang S (2015)	1
RRAGA	1	RRAGD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sekiguchi T (2001), Sekiguchi T (2001), Huttlin EL (2015), Huttlin EL (2017)	4
LGALS3	0	RRAGC	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRAGA	1	TSC1	4	affinity chromatography technology	Demetriades C (2014)	1
RRAGA	1	LAMTOR1	0	affinity chromatography technology	Gong R (2011)	1
NOL8	2	RRAGC	3	affinity chromatography technology	Sekiguchi T (2004)	1
MIOS	3	RRAGC	3	affinity chromatography technology	Bar-Peled L (2013)	1
RRAGD	1	LAMTOR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2010), Sancak Y (2010), Sancak Y (2010)	3