PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DLG4	11	KCNJ4	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nehring RB (2000), Leonoudakis D (2004), Inanobe A (2002), Nehring RB (2000)	4
ASIC3	5	LIN7B	0	two hybrid, affinity chromatography technology	Hruska-Hageman AM (2004), Hruska-Hageman AM (2004)	2
KCNJ4	5	LIN7B	0	two hybrid, affinity chromatography technology	Olsen O (2002), Olsen O (2002)	2
LIN7B	0	CASK	18	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ12	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
ASIC3	5	DLG4	11	affinity chromatography technology	Hruska-Hageman AM (2004)	1
LIN7C	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNJ4	5	CASK	18	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
LIN7C	0	APBA1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	3
LIN7C	0	MPP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNJ12	0	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
MPP5	2	LIN7B	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNJ4	5	LIN7C	0	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
MPP2	0	LIN7B	0	affinity chromatography technology	Huttlin EL (2017)	1
CASK	18	DLG4	11	affinity chromatography technology, two hybrid	Chetkovich DM (2002), Chetkovich DM (2002)	2
LIN7C	0	MPP5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	3
KCNJ12	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
LIN7B	0	DLG4	11	affinity chromatography technology	Jo K (1999)	1
MOV10	6	LIN7B	0	affinity chromatography technology	Castello A (2012)	1
LIN7B	0	GRIN2B	30	affinity chromatography technology, pull down	Jo K (1999), Jo K (1999)	2
KCNJ12	0	APBA1	6	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7B	0	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
APBA1	6	CASK	18	pull down	Borg JP (1999)	1
KCNJ12	0	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
GRIN2B	30	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down	Sans N (2003), Inanobe A (2002), Irie M (1997), Niethammer M (1998), Lim IA (2002), Kornau HC (1995), Kornau HC (1995), Niethammer M (1996), Niethammer M (1996), Imamura F (2002)	10