PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PCBP2	3	IFIH1	2	affinity chromatography technology	You F (2009)	1
NLRC5	8	IFIH1	2	affinity chromatography technology	Cui J (2010)	1
IFIH1	2	APP	1	pull down	Olah J (2011)	1
MAVS	1	IFIH1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawai T (2005), Li S (2011), You F (2009), Wang S (2016), Wang S (2016)	5
IFIH1	2	PIAS2	2	affinity chromatography technology, affinity chromatography technology	Fu J (2011), Fu J (2011)	2
IFIH1	2	IDE	3	affinity chromatography technology	Li S (2011)	1
G3BP1	4	IFIH1	2	affinity chromatography technology	Hein MY (2015)	1
USP21	2	IFIH1	2	affinity chromatography technology	Fan Y (2014)	1
MAVS	1	PCBP2	3	affinity chromatography technology, affinity chromatography technology	You F (2009), You F (2009)	2
PTEN	24	IFIH1	2	genetic interference	Vizeacoumar FJ (2013)	1
G3BP1	4	APP	1	pull down	Olah J (2011)	1
MPZL1	0	IFIH1	2	affinity chromatography technology	Huttlin EL (2017)	1
IFIH1	2	USP3	1	affinity chromatography technology, enzymatic study	Cui J (2014), Cui J (2014)	2
IFIH1	2	TSPAN6	0	affinity chromatography technology	Wang Y (2012)	1
IFIH1	2	RNF123	11	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang S (2016), Wang S (2016), Wang S (2016)	3
MAVS	1	TSPAN6	0	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Wang Y (2012)	2