PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DISC1	6	RBSN	2	two hybrid	Camargo LM (2007)	1
RBSN	2	RAB14	3	pull down	Eathiraj S (2005)	1
RBSN	2	RAB24	0	pull down	Eathiraj S (2005)	1
EHD3	0	EHD1	5	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Galperin E (2002), Galperin E (2002), Galperin E (2002), Naslavsky N (2006), Naslavsky N (2006)	5
RAB5C	2	RBSN	2	pull down	Merithew E (2003)	1
NINL	1	VPS45	0	bioid	Gupta GD (2015)	1
RAB5A	0	VPS45	0	affinity chromatography technology, affinity chromatography technology	Nielsen E (2000), Miaczynska M (2004)	2
EHD1	5	RBSN	2	two hybrid, pull down, two hybrid, affinity chromatography technology	Naslavsky N (2004), Henry GD (2010), Naslavsky N (2006), Huttlin EL (2017)	4
RBSN	2	LMX1B	1	affinity chromatography technology	Huttlin EL (2017)	1
RBSN	2	RAB22A	0	pull down, x-ray crystallography	Eathiraj S (2005), Eathiraj S (2005)	2
RBSN	2	IFFO1	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB22A	0	RAB5A	0	affinity chromatography technology	Zhu H (2009)	1
RBSN	2	RAB4A	0	pull down, x-ray crystallography	Eathiraj S (2005), Eathiraj S (2005)	2
TRIM25	5	PTK2	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	RBSN	2	affinity chromatography technology	Choudhury NR (2017)	1
RBSN	2	HSPA8	4	affinity chromatography technology	Rahajeng J (2010)	1
RBSN	2	RAB5A	0	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Nielsen E (2000), Nielsen E (2000), Schnatwinkel C (2004), Eathiraj S (2005), Mishra A (2010)	5
NINL	1	RBSN	2	bioid	Gupta GD (2015)	1
RAB5A	0	RAB5C	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
EHD1	5	EHD4	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
RBSN	2	EHD4	1	affinity chromatography technology	Huttlin EL (2017)	1
RBSN	2	VPS45	0	affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology	Rahajeng J (2010), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	4
EHD3	0	RBSN	2	two hybrid, two hybrid, affinity chromatography technology	Naslavsky N (2004), Naslavsky N (2006), Huttlin EL (2017)	3
RBSN	2	PTK2	2	affinity chromatography technology	Rahajeng J (2010)	1
RAB4A	0	RAB5A	0	biochemical	Vitale G (1998)	1
DTNBP1	1	RBSN	2	two hybrid	Camargo LM (2007)	1
RBSN	2	PCDHA4	1	affinity chromatography technology	Huttlin EL (2017)	1
EHD2	3	RBSN	2	two hybrid	Naslavsky N (2004)	1
MUSK	1	RBSN	2	affinity chromatography technology	Huttlin EL (2017)	1
RBSN	2	AVIL	0	affinity chromatography technology	Huttlin EL (2017)	1