PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K7	5	JUN	0	enzymatic study	Sundarrajan M (2003)	1
MAP2K6	2	MAPK14	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, fluorescent resonance energy transfe	Sanz-Moreno V (2003), Raingeaud J (1996), Stein B (1996), Chen Z (2001), Casar B (2007), Xia Y (1998), ter Haar E (2007), Ivanov AA (2017)	8
MAPK9	3	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
TRIM25	5	MAPK14	0	affinity chromatography technology	Choudhury NR (2017)	1
ARRB1	2	MAPK14	0	affinity chromatography technology	McLaughlin NJ (2006)	1
MAPK10	0	ARRB2	5	affinity chromatography technology, unspecified method	Miller WE (2001), Li X (2009)	2
ARRB1	2	MAPK9	3	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
TRIM25	5	MAP3K2	1	affinity chromatography technology	Choudhury NR (2017)	1
LRRK2	5	AKT1	1	enzymatic study, pull down	Ohta E (2011), Ohta E (2011)	2
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
BLNK	2	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Oellerich T (2011), Oellerich T (2011)	2
MAP3K7	2	ITCH	1	affinity chromatography technology	Kathania M (2015)	1
MAPK9	3	MAP2K7	5	unspecified method, enzymatic study	Ho DT (2006), Enomoto A (2003)	2
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MAP4K2	1	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yuasa T (1998), Chadee DN (2002), Chadee DN (2002)	3
MAPK10	0	ARRB1	2	affinity chromatography technology, unspecified method	Miller WE (2001), Li X (2009)	2
MAPK1	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
MAPK8IP3	9	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Song JJ (2004)	5
ARRB1	2	MAP3K1	4	affinity chromatography technology	Xiao K (2007)	1
MAP3K11	7	MAP2K7	5	enzymatic study, enzymatic study	Merritt SE (1999), Zhang H (2004)	2
ARRB2	5	MAP2K4	3	affinity chromatography technology, unspecified method	McDonald PH (2000), Li X (2009)	2
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
MAP3K7	2	MAP2K4	3	enzymatic study, affinity chromatography technology	Ge B (2003), Li MG (2003)	2
LRRK2	5	MAP2K6	2	enzymatic study, affinity chromatography technology, enzymatic study	Gloeckner CJ (2009), Hsu CH (2010), Hsu CH (2010)	3
SPAG9	5	MAP3K3	3	affinity chromatography technology	Lee CM (2002)	1
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
MAP2K4	3	ITCH	1	affinity chromatography technology, pull down, enzymatic study	Ahn YH (2009), Ahn YH (2009), Ahn YH (2009)	3
GCH1	0	MAP2K4	3	affinity chromatography technology	Chiarini A (2009)	1
MAP3K4	1	MAP2K6	2	enzymatic study, enzymatic study, two hybrid, pull down, enzymatic study, enzymatic study, imaging technique	Chan-Hui PY (1998), Abell AN (2005), Takekawa M (2005), Takekawa M (2005), Takekawa M (2005), Abell AN (2007), Chen TC (2014)	7
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
MAP2K7	5	MAP3K5	1	affinity chromatography technology	Zama T (2002)	1
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
MAP3K3	3	NBR1	0	affinity chromatography technology, affinity chromatography technology	Hernandez ED (2014), Hernandez ED (2014)	2
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
MAP4K2	1	MAP3K11	7	affinity chromatography technology	Chadee DN (2002)	1
AKT1	1	MAP3K8	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kane LP (2002), Kane LP (2002), Kane LP (2002)	3
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
MAP3K2	1	MAP2K7	5	affinity chromatography technology, biochemical, enzymatic study	Cheng J (2000), Cheng J (2000), Takeda AN (2014)	3
MAP3K5	1	MAP2K6	2	pull down, enzymatic study, two hybrid, enzymatic study, enzymatic study	Huang S (2003), Morita K (2001), Takekawa M (2005), Mo JS (2010), Hwang SG (2014)	5
SPAG9	5	MAP2K4	3	affinity chromatography technology	Lee CM (2002)	1
MAP3K11	7	AKT1	1	affinity chromatography technology, pull down	Barthwal MK (2003), Barthwal MK (2003)	2
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
ARRB1	2	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Zhang Z (2009), Li X (2009), Li X (2009)	3
MAPK9	3	ARRB2	5	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
NBR1	0	UBC	7	pull down, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down	Waters S (2009), Kirkin V (2009), Walinda E (2014), Walinda E (2014), Nicot AS (2014), Nakayasu ES (2013), Nakayasu ES (2013), Zhang X (2017)	8
MAP3K1	4	JUN	0	enzymatic study	Park KJ (2003)	1
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
UBC	7	MAP2K4	3	pull down	Zhang X (2017)	1
MAP2K4	3	VASP	0	biochemical	Wan C (2015)	1
MAP2K4	3	MAP3K5	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Ryoo K (2004), Song JJ (2004), Kim EK (2007), Zhang H (2004)	4
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
MAP2K4	3	KTI12	1	biochemical	Wan C (2015)	1
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
ARRB2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Shenoy SK (2008), Bhandari D (2007), Bhandari D (2007)	3
NPHS1	2	MAP2K6	2	genetic interference	Huber TB (2001)	1
MAPK8	3	GEMIN5	1	affinity chromatography technology, pull down	Kim EK (2007), Kim EK (2007)	2
ARRB1	2	UBC	7	affinity chromatography technology	Xiao K (2007)	1
MAP2K6	2	MAP2K4	3	enzymatic study	Takekawa M (2005)	1
PML	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Warren DT (2010), Lim JH (2011), Lim JH (2011)	3
MAP2K4	3	MAPK1	1	pull down	Ho DT (2003)	1
ITCH	1	LRRK2	5	affinity chromatography technology	OConnor HF (2015)	1
MAPK9	3	AKT1	1	enzymatic study	Xiao L (2010)	1
MAP3K5	1	MAP3K7	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochida Y (2000), Mochida Y (2000), Mochida Y (2000), Kim SY (2012), Kim SY (2012)	5
MAP2K4	3	JUN	0	enzymatic study	Sundarrajan M (2003)	1
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
SPAG9	5	MAPK8	3	affinity chromatography technology	Lee CM (2002)	1
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
MAP3K4	1	MAP2K4	3	enzymatic study, pull down	Chan-Hui PY (1998), Takekawa M (2005)	2
MAP2K4	3	PML	7	imaging technique	Yasuda S (1999)	1
LRRK2	5	MAP2K4	3	enzymatic study	Gloeckner CJ (2009)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
MAPK9	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, enzymatic study	Kallunki T (1996), Natoli G (1997), Chin AI (1999), Ho DT (2006), Yao K (2009), Gupta S (1996), Gupta S (1996), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Katagiri C (2006), Yao K (2007), Phelan DR (2001), Ho DT (2003), Camps M (1998)	16
EGFR	5	MAP2K4	3	affinity chromatography technology	Tong J (2014)	1
PML	7	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Kuo HY (2013), Kuo HY (2013), Kuo HY (2013), Kuo HY (2013)	4
ARRB2	5	MAP3K7	2	affinity chromatography technology	Xiao K (2007)	1
MAPK14	0	EGFR	5	enzymatic study	Raingeaud J (1995)	1
MAP3K3	3	MAP2K7	5	enzymatic study	Takeda AN (2014)	1
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
MAP3K1	4	MAP2K7	5	affinity chromatography technology, pull down	Tu Z (2003), Takekawa M (2005)	2
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MAP2K6	2	MAPK1	1	enzymatic study	Kumar S (1999)	1
MAPK8	3	MAP3K7	2	affinity chromatography technology, pull down	Sanna MG (2002), Sanna MG (2002)	2
MAP2K7	5	MAP3K4	1	pull down	Takekawa M (2005)	1
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
FLNB	11	FLNC	8	biochemical	Kristensen AR (2012)	1
MAPK8IP3	9	MAP3K1	4	affinity chromatography technology	Ito M (1999)	1
CDC5L	2	MAP2K4	3	affinity chromatography technology	Lleres D (2010)	1
MAP3K8	2	MAP2K4	3	enzymatic study	Salmeron A (1996)	1
MAP3K2	1	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study	Cheng J (2000), Deacon K (1997), Enomoto A (2008)	3
MAPK8	3	ITCH	1	enzymatic study, affinity chromatography technology	Gallagher E (2006), Gallagher E (2006)	2
TRIM25	5	FLNB	11	affinity chromatography technology	Choudhury NR (2017)	1
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
MAPK1	1	MAP2K7	5	unspecified method, enzymatic study, enzymatic study	Ho DT (2006), Mori S (1995), Saito T (2004)	3
MAP3K11	7	MAP2K4	3	enzymatic study	Merritt SE (1999)	1
TRIM25	5	MAP2K4	3	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
MAPK8IP3	9	MAP3K11	7	pull down	Kelkar N (2000)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
MAP3K3	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yamazaki K (2009), Yamazaki K (2009), Blonska M (2005), Blonska M (2005), Blonska M (2005)	5
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
MAP2K4	3	FLNC	8	two hybrid, pull down, affinity chromatography technology	Marti A (1997), Marti A (1997), Marti A (1997)	3
MAPK10	0	JUN	0	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, two hybrid, enzymatic study	Yao K (2009), Gupta S (1996), Gupta S (1996), Katagiri C (2006), Choi BY (2005), Wang J (2011), Camps M (1998)	7
MAPK8IP3	9	MAPK8	3	pull down, pull down, enzymatic study	Ito M (1999), Kelkar N (2000), Kelkar N (2000)	3
MAP3K3	3	MAP2K4	3	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Hernandez ED (2014), Hernandez ED (2014)	3
MAPK14	0	MAP2K7	5	enzymatic study	Tournier C (1997)	1
MAP2K4	3	RBBP8	1	two hybrid	Wang J (2011)	1
MAP3K2	1	MAPK8	3	affinity chromatography technology, biochemical	Cheng J (2000), Cheng J (2000)	2
GCH1	0	MAPK10	0	affinity chromatography technology, affinity chromatography technology	Chiarini A (2009), Chiarini A (2009)	2
MAP3K5	1	APP	1	imaging technique	Chen TC (2014)	1
MAP3K1	4	FLNB	11	affinity chromatography technology	Jeon YJ (2009)	1
MAP3K5	1	GEMIN5	1	affinity chromatography technology, affinity chromatography technology, pull down	Kim EK (2007), Kim EK (2007), Kim EK (2007)	3
MAP3K7	2	MAP2K7	5	imaging technique	Chen TC (2014)	1
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
MAP3K7	2	MAP2K6	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Ishitani T (2003), Wang C (2001), Ninomiya-Tsuji J (1999), Sakurai H (2000), Wu ZH (2010), Xia ZP (2009), Jiang Z (2003), Singhirunnusorn P (2005), Jiang Z (2002), Hong S (2007), Kojima H (2005), Huangfu WC (2006), Kajino T (2006), Li MG (2003), Wu X (2007), Shambharkar PB (2007), Kishimoto K (2000), Lamb A (2013), Lin J (2015), Liu X (2013), Ninomiya-Tsuji J (2003)	21
MAPK8IP3	9	MAPK9	3	pull down, pull down	Ito M (1999), Kelkar N (2000)	2
MAP3K4	1	MAPK8	3	enzymatic study, affinity chromatography technology	Sun BK (2011), Hein MY (2015)	2
ITCH	1	JUN	0	pull down, affinity chromatography technology, affinity chromatography technology	Gao B (2006), Ahmed SU (2009), Xie M (2010)	3
MAP4K2	1	MAP2K4	3	pull down	Yuasa T (1998)	1
TRIM25	5	MAPK9	3	affinity chromatography technology	Choudhury NR (2017)	1
MAP2K4	3	MAP2K4	3	enzymatic study	Deacon K (1997)	1
JUN	0	NBR1	0	affinity chromatography technology	Li X (2015)	1
CDC5L	2	MAP2K7	5	affinity chromatography technology	Lleres D (2010)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
MAPK8	3	MAP2K7	5	enzymatic study, enzymatic study, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Tournier C (1997), Tournier C (1997), Tournier C (1997), Cheng J (2000), Ho DT (2006), Ho DT (2006), Ho DT (2006), Ho DT (2006), Enomoto A (2003), Takeda AN (2014), Sundarrajan M (2003), Chen TC (2014), Zhu T (2016), Zhu T (2016)	14
MAPK8IP3	9	MAPK10	0	two hybrid, two hybrid, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Ito M (1999), Ito M (1999), Ito M (1999), Ito M (1999), Kelkar N (2000), Matsuura H (2002), Matsuura H (2002)	7
ARRB1	2	AKT1	1	affinity chromatography technology	Lodeiro M (2009)	1
MAP2K4	3	FLNB	11	affinity chromatography technology	Jeon YJ (2009)	1
ARRB2	5	FLNB	11	affinity chromatography technology	Huttlin EL (2017)	1
RBBP8	1	UBC	7	far western blotting, affinity chromatography technology	Murina O (2014), Unno J (2014)	2
AKT1	1	MAP2K4	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Park HS (2002), Park HS (2002), Park HS (2002), Song JJ (2005), Song JJ (2005)	5
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
MAP2K4	3	MAPK14	0	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Xia Y (1998), Xia Y (1998)	3
MAP2K4	3	NBR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Hernandez ED (2014), Hernandez ED (2014), Hernandez ED (2014)	3
ARRB1	2	MAP2K4	3	unspecified method	Li X (2009)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
ARRB2	5	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	McDonald PH (2000), Zhang Z (2009), Li X (2009)	3
MAPK8IP3	9	SPAG9	5	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP3	9	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Ito M (1999), Matsuura H (2002)	2
PML	7	JUN	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vallian S (1998), Yasuda S (1999), Salomoni P (2005), Salomoni P (2005), Seo SR (2006), Seo SR (2006), Seo SR (2006)	7
MAP2K4	3	APP	1	pull down	Olah J (2011)	1
EGFR	5	MAPK9	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SPAG9	5	MAPK14	0	affinity chromatography technology	Lee CM (2002)	1
MAP3K1	4	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Cheng J (2000), Gallagher ED (2004), Ryoo K (2004), Ryoo K (2004), Tu Z (2003), Takekawa M (2005), Xia Y (1998), Xia Y (1998), Gallagher ED (2002), Xia Y (1998), Chen Z (2006), Ahn JS (2016)	12
MAP2K4	3	MAPK10	0	enzymatic study, pull down, unspecified method	Ryoo K (2004), Ho DT (2003), Ho DT (2003)	3
MAPK10	0	APP	1	pull down	Olah J (2011)	1
TRIM25	5	VASP	0	affinity chromatography technology	Choudhury NR (2017)	1
JUN	0	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
MAPK14	0	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
MAPK1	1	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
ARRB1	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Bhandari D (2007)	2
EGFR	5	MAPK8	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MAP3K1	4	MAPK9	3	two hybrid, pull down	Gallagher ED (2004), Gallagher ED (2002)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
NPHS1	2	MAP2K4	3	genetic interference	Huber TB (2001)	1
APP	1	MAP3K11	7	pull down	Scheinfeld MH (2003)	1
MAPK8	3	FLNB	11	affinity chromatography technology	Jeon YJ (2009)	1
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
TRIM25	5	PML	7	affinity chromatography technology	Choudhury NR (2017)	1
AKT1	1	MAP3K5	1	affinity chromatography technology, enzymatic study	Kim AH (2001), Kim AH (2001)	2
MAP2K4	3	GEMIN5	1	affinity chromatography technology, pull down	Kim EK (2007), Kim EK (2007)	2
MAPK8IP3	9	MAP2K7	5	pull down, affinity chromatography technology	Kelkar N (2000), Matsuura H (2002)	2
TRIM25	5	SPAG9	5	affinity chromatography technology	Choudhury NR (2017)	1
MAP3K10	2	MAP2K4	3	enzymatic study	Hirai S (1997)	1
MAP2K6	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LRRK2	5	MAP2K7	5	enzymatic study, affinity chromatography technology, enzymatic study	Gloeckner CJ (2009), Hsu CH (2010), Hsu CH (2010)	3
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2