PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDPK1	0	BLMH	0	two hybrid	Vinayagam A (2011)	1
BLMH	0	GTF2A1	1	biochemical	Kristensen AR (2012)	1
BLMH	0	RPL29	0	two hybrid, pull down, biochemical	Koldamova RP (1999), Koldamova RP (1999), Koldamova RP (1999)	3
BLMH	0	LZTFL1	2	biochemical	Kristensen AR (2012)	1
G3BP1	4	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
SYNCRIP	6	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
G3BP1	4	MAPRE1	0	affinity chromatography technology	Jain S (2016)	1
BLMH	0	UBE2I	0	two hybrid, pull down, affinity chromatography technology	Koldamova RP (1998), Koldamova RP (1998), Koldamova RP (1998)	3
MAPRE1	0	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
PTP4A1	0	APP	1	pull down	Olah J (2011)	1
GTF2A1	1	GORASP2	1	biochemical	Kristensen AR (2012)	1
APP	1	RPL11	3	pull down	Virok DP (2011)	1
HNRNPD	3	UBE2I	0	two hybrid, pull down	Moraes KC (2003), Moraes KC (2003)	2
PDPK1	0	MAPK8	3	pull down	Park J (1999)	1
CUL4B	8	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	HNRNPD	3	affinity chromatography technology	Elliott PR (2016)	1
TRIM25	5	BLMH	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
PCDHB15	1	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
HERC2	9	BLMH	0	affinity chromatography technology	Galligan JT (2015)	1
MCM2	3	HNRNPD	3	affinity chromatography technology	Drissi R (2015)	1
COPS5	0	BLMH	0	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPD	3	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	CUL4B	8	affinity chromatography technology	Drissi R (2015)	1
LZTFL1	2	WDYHV1	0	two hybrid	Rolland T (2014)	1
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
ATL3	0	APP	1	pull down	Olah J (2011)	1
MAPK8	3	GORASP2	1	enzymatic study	Jesch SA (2001)	1
KERA	0	NUDT12	0	affinity chromatography technology	Huttlin EL (2017)	1
BLMH	0	NUDT12	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
COPS5	0	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
PTP4A1	0	BLMH	0	affinity chromatography technology	St-Denis N (2016)	1
TRIM25	5	ANLN	2	affinity chromatography technology	Choudhury NR (2017)	1
PES1	3	KBTBD7	3	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
MAST1	9	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
CYLD	2	G3BP1	4	affinity chromatography technology	Elliott PR (2016)	1
BAG6	2	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
CCDC8	1	RPL11	3	affinity chromatography technology	Hanson D (2014)	1
SORT1	1	SYNCRIP	6	affinity chromatography technology	Hein MY (2015)	1
ANLN	2	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
SGTB	2	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
RNF32	0	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
CYLD	2	RPL29	0	affinity chromatography technology	Elliott PR (2016)	1
AP1M2	2	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
CUL4B	8	SYNCRIP	6	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
CCDC8	1	HERC2	9	affinity chromatography technology	Hanson D (2014)	1
ATL3	0	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
BLMH	0	SH3GLB2	1	biochemical	Kristensen AR (2012)	1
USP53	1	BLMH	0	affinity chromatography technology	Sowa ME (2009)	1
USP7	14	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
PTP4A1	0	NUDT12	0	affinity chromatography technology	St-Denis N (2016)	1
BLMH	0	PES1	3	biochemical	Kristensen AR (2012)	1
PES1	3	LZTFL1	2	biochemical	Kristensen AR (2012)	1
ALDOC	0	BLMH	0	biochemical	Wan C (2015)	1
TRIM25	5	ATL3	0	affinity chromatography technology	Choudhury NR (2017)	1
G3BP1	4	APP	1	pull down	Olah J (2011)	1
ZBTB1	4	RPL11	3	affinity chromatography technology	Kim H (2014)	1
BLMH	0	TRIO	31	two hybrid	Stelzl U (2005)	1
ECSIT	3	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
SORT1	1	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	SYNCRIP	6	affinity chromatography technology	Bennett EJ (2010)	1
BLMH	0	WDYHV1	0	two hybrid	Rolland T (2014)	1
CYLD	2	SYNCRIP	6	affinity chromatography technology	Elliott PR (2016)	1
CYP2C8	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
PDPK1	0	APP	1	pull down	Olah J (2011)	1
CFTR	5	MCM2	3	affinity chromatography technology	Pankow S (2015)	1
CYLD	2	RPL11	3	affinity chromatography technology	Elliott PR (2016)	1
MCM2	3	SYNCRIP	6	affinity chromatography technology	Drissi R (2015)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
LIMK1	3	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
SH3GLB2	1	LZTFL1	2	biochemical	Kristensen AR (2012)	1
APP	1	MAPRE1	0	two hybrid, pull down	Kajiwara Y (2010), Olah J (2011)	2
MCM2	3	RPL11	3	affinity chromatography technology	Drissi R (2015)	1
CFTR	5	BLMH	0	affinity chromatography technology	Pankow S (2015)	1
APP	1	PES1	3	pull down	Virok DP (2011)	1
HNRNPD	3	SYNCRIP	6	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
UBE2I	0	CFTR	5	enzymatic study, enzymatic study	Ahner A (2013), Gong X (2016)	2
MCM2	3	G6PD	0	affinity chromatography technology	Drissi R (2015)	1
PDPK1	0	G3BP1	4	affinity chromatography technology	Behrends C (2010)	1
G3BP1	4	SYNCRIP	6	affinity chromatography technology	Jain S (2016)	1
TRIM25	5	TRIO	31	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
BLMH	0	KBTBD7	3	two hybrid	Rual JF (2005)	1
MCM2	3	APP	1	pull down	Olah J (2011)	1
PES1	3	G3BP1	4	affinity chromatography technology	Kellner M (2015)	1
BLMH	0	BLMH	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Soler-Lopez M (2011), Rolland T (2014)	3
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
MCM2	3	ALDOC	0	affinity chromatography technology	Drissi R (2015)	1
CYLD	2	BLMH	0	affinity chromatography technology	Elliott PR (2016)	1
SGTB	2	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
MAPRE1	0	COPS5	0	pull down	Peth A (2007)	1
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
CCDC8	1	SYNCRIP	6	affinity chromatography technology	Hanson D (2014)	1
BLMH	0	RPL11	3	two hybrid, pull down, biochemical	Koldamova RP (1999), Koldamova RP (1999), Koldamova RP (1999)	3
KERA	0	BLMH	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
BLMH	0	APP	1	pull down, biochemical	Lefterov IM (2000), Lefterov IM (2000)	2
LIMK1	3	APP	1	pull down	Olah J (2011)	1
MAST1	9	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
MCM2	3	BLMH	0	affinity chromatography technology	Drissi R (2015)	1
TRIM25	5	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Jain S (2016)	3
MAPRE1	0	TRIO	31	pull down	van Haren J (2014)	1
CCDC8	1	TRIM25	5	affinity chromatography technology	Hanson D (2014)	1
MAST1	9	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
CCDC8	1	G3BP1	4	affinity chromatography technology	Hanson D (2014)	1
TRIM25	5	USP53	1	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	ALDOC	0	affinity chromatography technology	Bennett EJ (2010)	1
GORASP2	1	APP	1	pull down	Olah J (2011)	1
COPS5	0	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
GORASP2	1	BLMH	0	biochemical	Kristensen AR (2012)	1
CUL4B	8	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
ZBTB1	4	BLMH	0	affinity chromatography technology	Kim H (2014)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
TRIM25	5	HERC2	9	affinity chromatography technology	Choudhury NR (2017)	1
CUL4B	8	APP	1	pull down	Olah J (2011)	1
TRIM25	5	BAG6	2	affinity chromatography technology	Choudhury NR (2017)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
CUL4B	8	BLMH	0	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	RPL11	3	affinity chromatography technology	Choudhury NR (2017)	1
CCDC8	1	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
TRIM25	5	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
UBE2I	0	ZBTB1	4	enzymatic study	Matic I (2010)	1
APP	1	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
BLMH	0	G6PD	0	biochemical	Wan C (2015)	1
CYLD	2	MAPRE1	0	affinity chromatography technology, affinity chromatography technology, pull down, genetic interference, two hybrid	Li D (2014), Li D (2014), Li D (2014), Li D (2014), Li D (2014)	5
SYNCRIP	6	BLMH	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
COPS5	0	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	BLMH	0	affinity chromatography technology	Hanson D (2014)	1
MAPK8	3	BLMH	0	affinity chromatography technology	Hein MY (2015)	1