PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PARK7	0	PPARGC1A	3	genetic interference	Zhong N (2008)	1
SFPQ	2	U2AF2	7	affinity chromatography technology, biochemical, affinity chromatography technology	Liu L (2011), Havugimana PC (2012), Whisenant TC (2015)	3
WWOX	3	NONO	3	affinity chromatography technology	Abu-Odeh M (2014)	1
U2AF2	7	PTBP1	2	affinity chromatography technology	Whisenant TC (2015)	1
ERG	1	NONO	3	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
SFPQ	2	PTBP1	2	pull down, affinity chromatography technology, affinity chromatography technology	Patton JG (1993), Meissner M (2000), Hall-Pogar T (2007)	3
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
PITX3	2	PARK7	0	imaging technique	Reddy SD (2011)	1
MAPK1	1	AR	3	pull down	Yeh S (1999)	1
WWOX	3	FUS	0	affinity chromatography technology	Abu-Odeh M (2014)	1
ERG	1	HNRNPA1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
PARK7	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Opsahl JA (2010), Opsahl JA (2010), Opsahl JA (2010)	3
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
AR	3	NONO	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ishitani K (2003), Ishitani K (2003), Ishitani K (2003), Dong X (2007)	4
HNRNPA1	1	PTBP1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Close P (2012), Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Wan C (2015)	5
SFPQ	2	SIN3A	13	affinity chromatography technology, imaging technique, affinity chromatography technology	Tyson-Capper AJ (2009), Dong X (2007), Liu L (2011)	3
NONO	3	SIN3A	13	affinity chromatography technology	Liu L (2011)	1
SFPQ	2	SNRPA	0	affinity chromatography technology, affinity chromatography technology	Liu L (2011), Hall-Pogar T (2007)	2
HNRNPA1	1	FUS	0	affinity chromatography technology	Roy R (2014)	1
U2AF2	7	HNRNPA1	1	affinity chromatography technology	Whisenant TC (2015)	1
CDC5L	2	SNRPA	0	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
SNRPA	0	U2AF2	7	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Hegele A (2012), Hegele A (2012), Hegele A (2012), Rolland T (2014), Yu H (2011)	5
RNF43	5	NONO	3	affinity chromatography technology, affinity chromatography technology	Miyamoto K (2008), Miyamoto K (2008)	2
NONO	3	U2AF2	7	affinity chromatography technology, biochemical, affinity chromatography technology	Liu L (2011), Wan C (2015), Whisenant TC (2015)	3
SFPQ	2	NONO	3	two hybrid, affinity chromatography technology, pull down, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Peng R (2002), Peng R (2002), Peng R (2002), Ito T (2008), Dong X (2007), Havugimana PC (2012), Wang J (2011), Hall-Pogar T (2007), Wan C (2015), Huttlin EL (2017)	10
NONO	3	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Liu L (2011), Liu L (2011), Liu L (2011), Liu L (2011)	4
ERG	1	TOP1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
WWOX	3	CDC5L	2	affinity chromatography technology	Abu-Odeh M (2014)	1
ERG	1	AR	3	affinity chromatography technology, affinity chromatography technology	Yu J (2010), Grasso CS (2012)	2
NONO	3	SNRPA	0	affinity chromatography technology	Liu L (2011)	1
CDC5L	2	PTBP1	2	affinity chromatography technology	Lleres D (2010)	1
SFPQ	2	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology	Zhong N (2008), Zhong N (2008)	2
ZMYM2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gocke CB (2008), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
TOP1	1	NONO	3	affinity chromatography technology	Czubaty A (2005)	1
ZMYM2	5	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Kasyapa CS (2005), Kasyapa CS (2005)	2
PTBP1	2	SNRPA	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid	Rual JF (2005), Hegele A (2012), Hegele A (2012), Hall-Pogar T (2007), Rolland T (2014)	5
CDC5L	2	U2AF2	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	David CJ (2011), David CJ (2011), Havugimana PC (2012), Lleres D (2010), Whisenant TC (2015)	5
FUS	0	NONO	3	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Wang T (2014), Wan C (2015)	3
TOP1	1	U2AF2	7	unspecified method	Trzcinska AM (2002)	1
WWOX	3	SFPQ	2	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
PARK7	0	AR	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Tillman JE (2007), Tillman JE (2007), Tillman JE (2007)	3
SNRPA	0	UBC	7	pull down	Komander D (2009)	1
ZMYM2	5	FUS	0	affinity chromatography technology	Kasyapa CS (2005)	1
AR	3	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Liu X (2016), Liu X (2016)	2
SFPQ	2	UBC	7	two hybrid, two hybrid, affinity chromatography technology, pull down	Stelzl U (2005), Stelzl U (2005), Matsumoto M (2005), Nathan JA (2013)	4
FUS	0	UBC	7	affinity chromatography technology	Wang T (2014)	1
CDC5L	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
MAPK1	1	PPARG	0	affinity chromatography technology, affinity chromatography technology	Jahrling JB (2014), Chen F (2003)	2
PITX3	2	NONO	3	affinity chromatography technology	Jacobs FM (2009)	1
FUS	0	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Lleres D (2010)	2
WWOX	3	TCERG1	3	pull down	Ingham RJ (2005)	1
HNRNPA1	1	SFPQ	2	affinity chromatography technology, affinity chromatography technology, biochemical	Close P (2012), Close P (2012), Wan C (2015)	3
CDC5L	2	SFPQ	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Havugimana PC (2012), Wan C (2015), Lleres D (2010)	5
STAT6	1	SFPQ	2	pull down, affinity chromatography technology, affinity chromatography technology	Dong L (2011), Dong L (2011), Dong L (2011)	3
PARK7	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Xu J (2005), Xu J (2005)	2
SFPQ	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Denner L (2010), Denner L (2010)	2
HDAC1	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Guo C (2007), Chen CS (2005)	2
HNRNPA1	1	NONO	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Close P (2012), Close P (2012), Roy R (2014)	3
SFPQ	2	TCERG1	3	biochemical, pull down	Havugimana PC (2012), Ingham RJ (2005)	2
CDC5L	2	NONO	3	affinity chromatography technology	Lleres D (2010)	1
RNF43	5	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Miyamoto K (2008), Miyamoto K (2008)	2
PPARG	0	PPARGC1A	3	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, unspecified method	Wallberg AE (2003), Wallberg AE (2003), Puigserver P (1999), Feige JN (2007), Kim K (2009), Qin C (2004), Narkar VA (2008), Agostini M (2006), Li Y (2008), Carmona MC (2007), Carmona MC (2007), Chintharlapalli S (2007), Wang LH (2007), Koppen A (2009), Koppen A (2009)	15
PPARG	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yoo EJ (2006), Yoo EJ (2006), Pancione M (2010)	3
CDC5L	2	TOP1	1	affinity chromatography technology	Lleres D (2010)	1
WWOX	3	PPP1CA	3	affinity chromatography technology	Abu-Odeh M (2014)	1
PITX3	2	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Jacobs FM (2009), Jacobs FM (2009)	2
TCERG1	3	NONO	3	pull down	Ingham RJ (2005)	1
FUS	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Wang T (2014), Wang T (2014), Wang T (2014), Wan C (2015)	4
TOP1	1	HNRNPA1	1	affinity chromatography technology	Czubaty A (2005)	1
TCERG1	3	U2AF2	7	affinity chromatography technology, pull down, pull down	Lin KT (2004), Ingham RJ (2005), Lin KT (2004)	3
SFPQ	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tyson-Capper AJ (2009), Dong L (2011), Liu L (2011), Zhong N (2006), Zhong N (2006)	5
NONO	3	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang C (2008), Xu J (2005), Xu J (2005)	3
HNRNPA1	1	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Huttlin EL (2015)	2
TOP1	1	SFPQ	2	affinity chromatography technology, affinity chromatography technology	Straub T (1998), Czubaty A (2005)	2
NONO	3	PTBP1	2	pull down	Hall-Pogar T (2007)	1
ERG	1	SFPQ	2	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
PPARG	0	UBC	7	enzymatic study	Hou Y (2012)	1
HDAC1	4	NONO	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Dong X (2007), Liu L (2011), Zhang C (2008)	3
PPARG	0	SFPQ	2	pull down, affinity chromatography technology, two hybrid	Tsukahara T (2013), Tsukahara T (2013), Tsukahara T (2013)	3
AR	3	SIN3A	13	affinity chromatography technology	Zhu P (2006)	1
U2AF2	7	PARK7	0	affinity chromatography technology	Whisenant TC (2015)	1
ERG	1	CDC5L	2	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
SFPQ	2	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu L (2011), Liu L (2011), Liu L (2011)	3
PPARG	0	STAT6	1	affinity chromatography technology, affinity chromatography technology, pull down	Szanto A (2010), Szanto A (2010), Szanto A (2010)	3
UBC	7	PTBP1	2	affinity chromatography technology	Matsumoto M (2005)	1
AR	3	SFPQ	2	affinity chromatography technology, pull down	Dong X (2007), Dong X (2007)	2
PTBP1	2	FUS	0	biochemical	Wan C (2015)	1