PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PJA1	1	UBE2L3	1	pull down	Zoabi M (2011)	1
PJA1	1	NSMCE4A	0	affinity chromatography technology	Huttlin EL (2017)	1
PJA1	1	SMC5	3	affinity chromatography technology	Huttlin EL (2017)	1
FAF2	4	RNF126	2	affinity chromatography technology	Alexandru G (2008)	1
RBFOX2	5	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
NSMCE4A	0	SMC5	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP28	3	OTUB2	0	enzymatic study	Loch CM (2012)	1
PJA1	1	TXNDC5	5	enzymatic study	Loch CM (2011)	1
PJA1	1	UBE2K	0	pull down	Loch CM (2011)	1
XPO1	8	PHGDH	4	affinity chromatography technology	Kirli K (2015)	1
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
USP28	3	JOSD1	1	enzymatic study	Loch CM (2012)	1
PJA1	1	HOMER2	0	enzymatic study	Loch CM (2011)	1
ATP5C1	0	PJA1	1	two hybrid	Stelzl U (2005)	1
F12	0	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
RNF126	2	USP7	14	affinity chromatography technology	OConnor HF (2015)	1
PJA1	1	TAF9	2	enzymatic study	Loch CM (2011)	1
SMC5	3	SMC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Taylor EM (2001), Taylor EM (2001), Taylor EM (2008), Taylor EM (2008), Wan C (2015), Hein MY (2015)	6
PJA1	1	USP20	3	enzymatic study	Loch CM (2012)	1
OTUB1	0	PHGDH	4	affinity chromatography technology	Scholz CC (2016)	1
PJA1	1	GLO1	0	enzymatic study	Loch CM (2011)	1
USP5	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
OTUB1	0	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009)	2
IQCN	0	PJA1	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	PJA1	1	affinity chromatography technology	Kirli K (2015)	1
NSMCE4A	0	DNAJB2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	ASCC2	3	pull down	Zhang X (2017)	1
EGLN3	0	TAF9	2	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	TMEM214	2	enzymatic study	Loch CM (2011)	1
SUZ12	0	ATP5C1	0	affinity chromatography technology	Cao Q (2014)	1
PJA1	1	USP28	3	enzymatic study	Loch CM (2012)	1
KIAA0753	1	PJA1	1	bioid	Firat-Karalar EN (2014)	1
AP2M1	5	UBC	7	affinity chromatography technology, pull down	Brehme M (2009), Zhang X (2017)	2
SMAD3	1	UCHL5	1	pull down, affinity chromatography technology	Wicks SJ (2005), Nan L (2016)	2
MORC1	0	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
UBE2L3	1	ATXN3	2	pull down	Durcan TM (2011)	1
DNAJB2	0	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
OTUB1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
PJA1	1	SPTBN1	6	pull down, affinity chromatography technology, pull down	Saha T (2006), Saha T (2006), Saha T (2006)	3
PJA1	1	MAGED4B	0	affinity chromatography technology	Huttlin EL (2017)	1
UCHL3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
PJA1	1	CAMK1G	3	enzymatic study	Loch CM (2011)	1
PJA1	1	OTUB2	0	enzymatic study	Loch CM (2012)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
PJA1	1	PIP4K2C	7	enzymatic study	Loch CM (2011)	1
USP28	3	USP51	1	enzymatic study	Loch CM (2012)	1
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
PJA1	1	TK1	0	enzymatic study	Loch CM (2011)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D2	0	RNF126	2	two hybrid, pull down, pull down, pull down	Markson G (2009), Hou X (2012), Smith CJ (2013), Delker RK (2013)	4
EGLN3	0	GTF2I	1	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	UBE2D3	1	pull down, pull down	Loch CM (2012), Loch CM (2011)	2
PJA1	1	NATD1	0	enzymatic study	Loch CM (2011)	1
EZH2	4	ATP5C1	0	affinity chromatography technology	Cao Q (2014)	1
USP8	7	UBC	7	enzymatic study, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, pull down	Faesen AC (2011), Ernst A (2013), Row PE (2007), Ernst A (2013), Wauer T (2015), Reincke M (2015), Kwasna D (2018)	7
PJA1	1	USP7	14	enzymatic study, affinity chromatography technology	Loch CM (2012), Huttlin EL (2017)	2
SMAD3	1	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
PJA1	1	TSSK3	3	enzymatic study	Loch CM (2011)	1
BCAT1	6	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
LRRC27	5	PJA1	1	affinity chromatography technology	Huttlin EL (2017)	1
IRAK1	1	MAGED1	0	affinity chromatography technology	Li S (2011)	1
GSR	1	PJA1	1	two hybrid	Stelzl U (2005)	1
AP2M1	5	PJA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP28	3	UCHL3	1	enzymatic study	Loch CM (2012)	1
PJA1	1	MAGEB4	0	enzymatic study	Loch CM (2011)	1
NSMCE3	0	SMC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Taylor EM (2008), Taylor EM (2008), Taylor EM (2008), Wan C (2015), Hein MY (2015)	5
AP2M1	5	SPTBN1	6	affinity chromatography technology	Brehme M (2009)	1
USP36	4	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
ATXN3L	0	UBC	7	x-ray crystallography, enzymatic study	Weeks SD (2011), Weeks SD (2011)	2
EGLN3	0	PJA1	1	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	PFKFB4	0	enzymatic study	Loch CM (2011)	1
STAM	3	STAMBP	2	pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, pull down	Kato M (2000), Tanaka N (1999), Tanaka N (1999), Tanaka N (1999), Kim MS (2006), Agromayor M (2006), McCullough J (2004), Sierra MI (2010), Sierra MI (2010), Sierra MI (2010), Row PE (2006), Kikuchi K (2003), McCullough J (2006), McCullough J (2006), Tsang HT (2006), Davies CW (2013), Davies CW (2013), McCullough J (2006)	18
USP28	3	ESPL1	2	enzymatic study	Loch CM (2012)	1
PJA1	1	PCCA	0	enzymatic study	Loch CM (2011)	1
PJA1	1	UCHL5	1	enzymatic study	Loch CM (2012)	1
PJA1	1	STAC	0	enzymatic study	Loch CM (2011)	1
USP28	3	STAM	3	enzymatic study	Loch CM (2012)	1
USP28	3	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down	Loch CM (2012), Zhen Y (2014), Wen Y (2015), Wen Y (2015), Wen Y (2015), Wrigley JD (2017), Kwasna D (2018)	7
PJA1	1	STAMBP	2	enzymatic study	Loch CM (2012)	1
PJA1	1	METAP2	3	enzymatic study	Loch CM (2011)	1
USP20	3	UCHL3	1	affinity chromatography technology	Sowa ME (2009)	1
HNRNPLL	1	PJA1	1	affinity chromatography technology	Huttlin EL (2017)	1
TK1	0	EZH2	4	two hybrid	Vinayagam A (2011)	1
PJA1	1	C21orf33	0	enzymatic study	Loch CM (2011)	1
OTUB1	0	RNF126	2	two hybrid	Hayes SD (2012)	1
XPO1	8	IRAK1	1	affinity chromatography technology	Kirli K (2015)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	EZH2	4	enzymatic study, affinity chromatography technology	Zoabi M (2011), Shen Z (2013)	2
PJA1	1	ESPL1	2	enzymatic study	Loch CM (2012)	1
NSMCE4A	0	SMC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taylor EM (2008), Taylor EM (2008), Taylor EM (2008), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
PJA1	1	CHRAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF126	2	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
XPO1	8	ESPL1	2	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	USP7	14	affinity chromatography technology, two hybrid	Brown KA (2008), Wang J (2011)	2
EGLN3	0	USP9X	15	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	ELAC1	0	enzymatic study	Loch CM (2011)	1
JOSD1	1	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down	Nicastro G (2009), Nicastro G (2009), Seki T (2013), Weeks SD (2011), Kwasna D (2018)	5
EGLN3	0	RBFOX2	5	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
STAM	3	UBC	7	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, unspecified method, pull down, pull down, x-ray crystallography, pull down	Kim MS (2006), Mizuno E (2006), Hong YH (2009), Nathan JA (2013), Nathan JA (2013), Stuible M (2010), Lim J (2011), Baiady N (2016), Kharitidi D (2015), Sundd M (2012), Zhang X (2017)	11
PJA1	1	USP51	1	enzymatic study	Loch CM (2012)	1
OTUB1	0	DDX54	1	affinity chromatography technology	Edelmann MJ (2009)	1
PJA1	1	NAGK	4	enzymatic study	Loch CM (2011)	1
UBE2D2	0	F12	0	pull down	Koh MY (2008)	1
UBE2D3	1	F12	0	pull down	Koh MY (2008)	1
USP7	14	GTF2I	1	affinity chromatography technology	Sowa ME (2009)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
EGLN3	0	FAF2	4	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	PJA1	1	enzymatic study, enzymatic study	Zoabi M (2011), Yu P (2002)	2
UBC	7	GTF2I	1	pull down	Zhang X (2017)	1
FAF2	4	PJA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PJA1	1	GTF2I	1	enzymatic study	Loch CM (2011)	1
PJA1	1	JOSD1	1	enzymatic study	Loch CM (2012)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
PJA1	1	USP8	7	enzymatic study	Loch CM (2012)	1
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
XPO1	8	CDK16	0	affinity chromatography technology	Kirli K (2015)	1
MAGED1	0	PJA1	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down	Sasaki A (2002), Sasaki A (2002), Sasaki A (2002), Sasaki A (2002), Doyle JM (2010), Doyle JM (2010)	6
OTUB1	0	UBE2E3	0	affinity chromatography technology, affinity chromatography technology	Scholz CC (2016), Huttlin EL (2017)	2
USP9X	15	PJA1	1	affinity chromatography technology	Agrawal P (2012)	1
PJA1	1	LRG1	1	enzymatic study	Loch CM (2011)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
PJA1	1	FGF12	4	enzymatic study	Loch CM (2011)	1
USP9X	15	MAGED1	0	affinity chromatography technology	Agrawal P (2012)	1
UBC	7	UCHL5	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, pull down, pull down, enzymatic study, pull down, x-ray crystallography, pull down	Matsumoto M (2005), Boudreaux D (2012), Sahtoe DD (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	10
PJA1	1	UCHL3	1	enzymatic study	Loch CM (2012)	1
UBC	7	ATP5C1	0	affinity chromatography technology	Matsumoto M (2005)	1
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
TK1	0	SMC5	3	two hybrid	Vinayagam A (2011)	1
USP28	3	USP20	3	enzymatic study	Loch CM (2012)	1
XPO1	8	METAP2	3	affinity chromatography technology	Kirli K (2015)	1
NSMCE3	0	NSMCE4A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Hudson JJ (2011), Huttlin EL (2015), Huttlin EL (2017)	4
EZH2	4	PHGDH	4	affinity chromatography technology	Cao Q (2014)	1
EED	1	GTF2I	1	affinity chromatography technology	Cao Q (2014)	1
EGLN3	0	PHGDH	4	affinity chromatography technology	Rodriguez J (2016)	1
NSMCE3	0	PJA1	1	affinity chromatography technology, pull down, affinity chromatography technology	Doyle JM (2010), Doyle JM (2010), Huttlin EL (2017)	3
USP28	3	OTUB1	0	enzymatic study	Loch CM (2012)	1
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
PJA1	1	DDX54	1	enzymatic study	Loch CM (2011)	1
DNAJB2	0	ATXN3	2	affinity chromatography technology	Gao XC (2011)	1
OTUB1	0	UBE2L3	1	affinity chromatography technology	Scholz CC (2016)	1
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
USP8	7	OTUB1	0	affinity chromatography technology	Soares L (2004)	1
PJA1	1	ATXN3L	0	enzymatic study	Loch CM (2012)	1
EED	1	TXNDC5	5	affinity chromatography technology	Cao Q (2014)	1
TK1	0	ATXN3	2	two hybrid	Vinayagam A (2011)	1
AP2M1	5	MAGED4B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NSMCE3	0	SMC5	3	biochemical	Wan C (2015)	1
USP28	3	USP5	2	enzymatic study	Loch CM (2012)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
RIBC2	1	PJA1	1	two hybrid	Stelzl U (2005)	1
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
MAGED1	0	RBFOX2	5	two hybrid	Rolland T (2014)	1
EGLN3	0	IRAK1	1	affinity chromatography technology	Rodriguez J (2016)	1
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
EGLN3	0	RNF126	2	affinity chromatography technology	Rodriguez J (2016)	1
ASCC2	3	PJA1	1	two hybrid	Stelzl U (2005)	1
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
XPO1	8	HNRNPC	0	affinity chromatography technology	Kirli K (2015)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
EED	1	HNRNPC	0	affinity chromatography technology	Cao Q (2014)	1
SUZ12	0	PHGDH	4	affinity chromatography technology	Cao Q (2014)	1
EGLN3	0	UCHL5	1	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	SMC6	3	affinity chromatography technology	Huttlin EL (2017)	1
MAGED4B	0	NSMCE4A	0	affinity chromatography technology	Hudson JJ (2011)	1
PJA1	1	STAM	3	enzymatic study	Loch CM (2012)	1
CHRAC1	0	TALDO1	2	biochemical	Kristensen AR (2012)	1
SUZ12	0	GTF2I	1	affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Cao Q (2014)	2
UBC	7	HNRNPC	0	affinity chromatography technology	Matsumoto M (2005)	1
PJA1	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
OTUB2	0	RNF126	2	two hybrid	Hayes SD (2012)	1
FAF2	4	MAGED1	0	affinity chromatography technology	Raman M (2015)	1
UBC	7	PHGDH	4	affinity chromatography technology	Matsumoto M (2005)	1
PJA1	1	COASY	1	enzymatic study	Loch CM (2011)	1
USP28	3	USP7	14	enzymatic study	Loch CM (2012)	1
PJA1	1	LCP2	0	enzymatic study	Loch CM (2011)	1
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	EED	1	enzymatic study	Zoabi M (2011)	1
UBE2L3	1	UCHL3	1	biochemical	Havugimana PC (2012)	1
USP7	14	SUZ12	0	pull down	de Bie P (2010)	1
USP7	14	EZH2	4	pull down	de Bie P (2010)	1
PJA1	1	PHGDH	4	enzymatic study	Loch CM (2011)	1
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
PJA1	1	SUZ12	0	enzymatic study	Zoabi M (2011)	1
USP28	3	USP8	7	enzymatic study	Loch CM (2012)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
PJA1	1	OTUB1	0	enzymatic study	Loch CM (2012)	1
ATXN3	2	OTUB2	0	affinity chromatography technology	Sowa ME (2009)	1
SPTBN1	6	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
UBC	7	USP36	4	pull down	Kwasna D (2018)	1
UBE2D3	1	RNF126	2	two hybrid, two hybrid, pull down	Rual JF (2005), Markson G (2009), Delker RK (2013)	3
USP28	3	ATXN3L	0	enzymatic study	Loch CM (2012)	1
IRAK1	1	PJA1	1	affinity chromatography technology	Li S (2011)	1
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	PJA1	1	affinity chromatography technology	Brown KA (2008)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
SFXN3	0	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
OTUB1	0	PNKD	2	affinity chromatography technology	Scholz CC (2016)	1
PJA1	1	ABR	5	enzymatic study	Loch CM (2011)	1
UBE2U	0	PJA1	1	two hybrid	van Wijk SJ (2009)	1
DNAJB2	0	UBC	7	affinity chromatography technology, pull down, two hybrid	Westhoff B (2005), Fenner BJ (2009), Westhoff B (2005)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
PHGDH	4	USP7	14	biochemical	Wan C (2015)	1
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
OTUB2	0	GTF2I	1	affinity chromatography technology	Sowa ME (2009)	1
KIAA0753	1	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
PJA1	1	389903	0	enzymatic study	Loch CM (2011)	1
PJA1	1	CDK16	0	enzymatic study	Loch CM (2011)	1
USP28	3	UCHL5	1	enzymatic study	Loch CM (2012)	1
PNKD	2	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
KIF22	1	PJA1	1	two hybrid	Stelzl U (2005)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
USP28	3	STAMBP	2	enzymatic study	Loch CM (2012)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
USP7	14	EED	1	pull down, affinity chromatography technology	de Bie P (2010), Cao Q (2014)	2
EGLN3	0	ATP5C1	0	affinity chromatography technology	Rodriguez J (2016)	1
PJA1	1	USP5	2	enzymatic study	Loch CM (2012)	1
UBE2E3	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	PJA1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yu P (2002), Yu P (2002), Yu P (2002), Loch CM (2011)	4
PJA1	1	HNRNPC	0	enzymatic study	Loch CM (2011)	1
TALDO1	2	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
UBC	7	USP20	3	pull down	Kwasna D (2018)	1
PJA1	1	UBE2E3	0	pull down	Loch CM (2011)	1
EGLN3	0	MAGED1	0	affinity chromatography technology	Rodriguez J (2016)	1
USP8	7	STAM	3	pull down, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Kato M (2000), Berlin I (2010), Berlin I (2010), Row PE (2006)	4
EGLN3	0	PNKD	2	affinity chromatography technology	Rodriguez J (2016)	1
DOCK5	6	PJA1	1	affinity chromatography technology	Huttlin EL (2017)	1
OTUB1	0	ATP5C1	0	affinity chromatography technology	Scholz CC (2016)	1