Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ABCG8 rs11887534 GG atorvastatin efficacy no as measured by decreases in LDL-cholestrol. No significant association was seen between all three genotypes and response. Genotype GG is not associated with response to atorvastatin as compared to genotype CG. 16103896 982045958
ABCG8 rs11887534 CC + CG atorvastatin efficacy yes as measured by larger reductions in LDL cholesterol in patients with the C allele. Variant described as D19H. The effect of the rs11887534 C allele was greater in patients with the rs3808607 TT genotype and became smaller with increased number of rs3808607 G alleles. Genotypes CC + CG are associated with increased response to atorvastatin in people with Hypercholesterolemia as compared to genotype GG. 15262185 982043865
ABCG8 rs11887534 CG atorvastatin efficacy yes Alleles were reported as "D = wildtype" and "H = variant". This gene is on the + strand, and dbSNP reports G to be the extremely major allele in every population, so I interpreted D to be G and H to be C. There were no HH (CC) homozygotes. The response measured was lowering of LDL-C. Genotype CG is not associated with increased response to atorvastatin in people with Coronary Artery Disease as compared to genotype GG. 20592455 981501315