PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AFF1	1	RELA	1	affinity chromatography technology, affinity chromatography technology	Benedikt A (2011), Benedikt A (2011)	2
NSD1	25	NR5A2	4	two hybrid	Chan CM (2013)	1
VDR	2	KDM5A	6	pull down	Chan SW (2001)	1
TRIM25	5	NR2F2	4	affinity chromatography technology	Choudhury NR (2017)	1
ZBTB48	3	HIST1H1C	2	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3A	3	MECP2	36	bioid	Lambert JP (2015)	1
TRIM25	5	HIST1H1C	2	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
BMI1	0	AR	3	affinity chromatography technology	Cao Q (2014)	1
AFF1	1	5430	0	affinity chromatography technology	Benedikt A (2011)	1
NSD1	25	RARA	5	two hybrid	Chan CM (2013)	1
5430	0	NSD1	25	affinity chromatography technology, pull down	Chu G (2014), Chu G (2014)	2
ESRRA	2	ESR1	0	pull down	Klinge CM (1997)	1
PPARG	0	VDR	2	pull down, affinity chromatography technology	Alimirah F (2012), Alimirah F (2012)	2
VDR	2	5430	0	imaging technique, imaging technique	Vaeisaenen S (2005), Dunlop TW (2005)	2
NSD1	25	HIST1H3A	3	enzymatic study, unspecified method, pull down	Morishita M (2014), Sankaran SM (2016), Sankaran SM (2016)	3
BMI1	0	ATRX	7	affinity chromatography technology, biochemical	Abdouh M (2016), Abdouh M (2016)	2
TRIM25	5	RXRA	1	affinity chromatography technology	Choudhury NR (2017)	1
ATRX	7	HIST1H1C	2	affinity chromatography technology	Leung JW (2013)	1
NSD1	25	NR2F2	4	two hybrid	Chan CM (2013)	1
KDM5A	6	NSD1	25	genetic interference	Wong AS (2016)	1
MECP2	36	NSD1	25	affinity chromatography technology	Huttlin EL (2017)	1
NSD1	25	TNFRSF21	2	two hybrid, pull down	Mai T (2004), Mai T (2004)	2
TRIM25	5	NSD1	25	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	KDM5A	6	affinity chromatography technology	Choudhury NR (2017)	1
NSD1	25	HNF4G	1	two hybrid	Chan CM (2013)	1
ZBTB48	3	NSD1	25	affinity chromatography technology	Huttlin EL (2017)	1
NSD1	25	HIST1H4A	0	enzymatic study	Morishita M (2014)	1
NSD1	25	HIST3H3	0	enzymatic study	Kudithipudi S (2014)	1
HIST1H4A	0	ATRX	7	affinity chromatography technology	Huttlin EL (2017)	1
SIRT7	1	HIST1H1D	1	affinity chromatography technology	Tsai YC (2012)	1
AR	3	NSD1	25	two hybrid, pull down, two hybrid	Wang X (2001), Wang X (2001), Chan CM (2013)	3
NSD1	25	PPARG	0	two hybrid	Chan CM (2013)	1
ESR1	0	KDM5A	6	pull down, affinity chromatography technology	Chan SW (2001), Chan SW (2001)	2
ZFY	0	NSD1	25	affinity chromatography technology	Huttlin EL (2017)	1
5430	0	RELA	1	imaging technique	Freaney JE (2013)	1
NSD1	25	RORA	4	two hybrid	Chan CM (2013)	1
ZNF496	1	NSD1	25	two hybrid, affinity chromatography technology, two hybrid, pull down	Nielsen AL (2004), Nielsen AL (2004), Nielsen AL (2004), Nielsen AL (2004)	4
NSD1	25	HIST1H1D	1	enzymatic study	Kudithipudi S (2014)	1
BMI1	0	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
RELA	1	RXRA	1	pull down, imaging technique, pull down	Na SY (1999), Chen TC (2014), Gu X (2006)	3
VDR	2	RXRA	1	pull down, two hybrid, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique, imaging technique, pull down, pull down, pull down, pull down, pull down, two hybrid, pull down, two hybrid, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, imaging technique, two hybrid, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Baudino TA (1998), Baudino TA (1998), Zhang C (2001), Song CS (2006), Dunlop TW (2005), Ting HJ (2005), Kim S (2005), Kim S (2005), Solomon C (2001), Liu YY (2000), Liu YY (2000), Rachez C (2000), Jimenez-Lara AM (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Ismail A (2004), Carvallo L (2008), Peleg S (2010), Albers M (2005), Herdick M (2000), Pedigo NG (2005), Hsieh JC (2003), Sorg BL (2006), Seuter S (2007), Seuter S (2007), Wang J (2011), Bartik L (2010), Rochel N (2011), Molnar F (2005), Ahmad K (2015), Ahmad K (2015)	32
ESR1	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Ohtake F (2007), Ohtake F (2007)	2
RXRA	1	5430	0	imaging technique	Sinkkonen L (2005)	1
THRB	1	RXRA	1	pull down, pull down, two hybrid, far western blotting, two hybrid, pull down, pull down, pull down, imaging technique	Monden T (1997), Jeyakumar M (1997), Tagami T (2009), Li H (1997), Albers M (2005), White DM (1997), Garcia-Fernandez LF (1998), Liao CS (2009), Liao CS (2009)	9
PPARG	0	ZNF496	1	two hybrid	Ravasi T (2010)	1
HIST3H3	0	KDM5A	6	unspecified method	Vermeulen M (2010)	1
RELA	1	PPARG	0	affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Hou Y (2012), Hou Y (2012), Lu X (2013), Chen F (2003), Chen F (2003), Perez A (2008), Jeninga EH (2007)	7
SIRT7	1	5430	0	affinity chromatography technology	Tsai YC (2012)	1
TRIM25	5	RARA	5	affinity chromatography technology	Choudhury NR (2017)	1
RELA	1	AR	3	genetic interference, genetic interference	Aarnisalo P (1998), Aarnisalo P (1998)	2
NSD1	25	ATRX	7	enzymatic study	Kudithipudi S (2014)	1
AFF1	1	HIST3H3	0	enzymatic study	Benedikt A (2011)	1
BMI1	0	HIST4H4	1	affinity chromatography technology	Cao Q (2014)	1
NSD1	25	RXRA	1	two hybrid	Chan CM (2013)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
SIRT7	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsai YC (2012), Mo Y (2017), Mo Y (2017), Mo Y (2017)	4
GAR1	0	NSD1	25	affinity chromatography technology	Hein MY (2015)	1
HIST1H1C	2	5430	0	affinity chromatography technology, pull down	Kim K (2013), Kim K (2013)	2
TRIM25	5	AFF1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
SIRT7	1	HIST1H4A	0	pull down	Ford E (2006)	1
NSD1	25	NR2E1	0	two hybrid	Chan CM (2013)	1
NR2F6	1	ESR1	0	pull down	Zhu XG (2000)	1
ZNF692	3	NSD1	25	affinity chromatography technology	Huttlin EL (2017)	1
VDR	2	AFF1	1	affinity chromatography technology	Ahmad K (2015)	1
NSD1	25	AFF1	1	affinity chromatography technology	Benedikt A (2011)	1
BMI1	0	HIST1H3A	3	affinity chromatography technology	Abdouh M (2016)	1
BMI1	0	NSD1	25	genetic interference	Wong AS (2016)	1
NSD1	25	THRB	1	two hybrid	Chan CM (2013)	1
SIRT7	1	NSD1	25	affinity chromatography technology	Tsai YC (2012)	1
RXRA	1	NR2F6	1	two hybrid	Avram D (1999)	1
NR2F1	9	ESR1	0	affinity chromatography technology, pull down, two hybrid, pull down	Metivier R (2002), Metivier R (2002), Metivier R (2002), Klinge CM (1997)	4
NSD1	25	VDR	2	two hybrid	Chan CM (2013)	1
HIST1H3A	3	HIST1H1B	4	imaging technique	Soldi M (2013)	1
NSD1	25	ESR1	0	two hybrid	Chan CM (2013)	1
MECP2	36	PPARG	0	affinity chromatography technology	Pancione M (2010)	1
HIST3H3	0	HIST4H4	1	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
RELA	1	NSD1	25	affinity chromatography technology	Lu T (2010)	1
NSD1	25	HIST1H1C	2	enzymatic study	Kudithipudi S (2014)	1
NSD1	25	SNORD3A	0	enzymatic study	Kudithipudi S (2014)	1
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
CUL4B	8	NSD1	25	affinity chromatography technology	Yang Y (2015)	1
ESR1	0	5430	0	affinity chromatography technology, imaging technique, imaging technique, pull down	Ambrosino C (2010), Zhang H (2006), Zhang H (2006), Nalvarte I (2010)	4
HIST3H3	0	BMI1	0	unspecified method	Vermeulen M (2010)	1
VDR	2	RELA	1	affinity chromatography technology	Fekrmandi F (2015)	1
NR2F2	4	NR2F6	1	two hybrid, pull down, two hybrid, affinity chromatography technology	Avram D (1999), Avram D (1999), Albers M (2005), Huttlin EL (2017)	4
NSD1	25	HIST1H1B	4	enzymatic study	Kudithipudi S (2014)	1
TRIM25	5	SNORD3A	0	affinity chromatography technology	Choudhury NR (2017)	1
NSD1	25	NR6A1	3	two hybrid	Chan CM (2013)	1
NSD1	25	RORB	3	two hybrid	Chan CM (2013)	1
NSD1	25	ESRRA	2	two hybrid	Chan CM (2013)	1
CUL4B	8	HIST1H1C	2	affinity chromatography technology	Bennett EJ (2010)	1
SIRT7	1	HIST1H3A	3	pull down	Ford E (2006)	1
NR2F6	1	THRB	1	pull down, two hybrid, affinity chromatography technology	Zhu XG (2000), Zhu XG (2000), Zhu XG (2000)	3
ATRX	7	HIST1H3A	3	pull down	Dhayalan A (2011)	1
NSD1	25	HIST4H4	1	x-ray crystallography, enzymatic study	Morishita M (2011), Kudithipudi S (2014)	2
NSD1	25	NR2F1	9	two hybrid	Chan CM (2013)	1
NSD1	25	NR2F6	1	two hybrid	Chan CM (2013)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
HIST1H3A	3	HIST1H1C	2	imaging technique	Soldi M (2013)	1
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
RARA	5	KDM5A	6	pull down	Chan SW (2001)	1
TRIM25	5	ESRRA	2	affinity chromatography technology	Choudhury NR (2017)	1