PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIF1AN	0	AZI2	1	affinity chromatography technology	Rodriguez J (2016)	1
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
AZI2	1	TXLNA	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
AZI2	1	N4BP1	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
EGLN3	0	MIB1	5	affinity chromatography technology	Rodriguez J (2016)	1
TBK1	1	MIB1	5	affinity chromatography technology, pull down, enzymatic study	Li S (2011), Li S (2011), Li S (2011)	3
AZI2	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Fujita F (2003), Fujita F (2003), Fujita F (2003), Fujita F (2003), Ryzhakov G (2007), Seo S (2013)	8
AZI2	1	MIB1	5	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
AZI2	1	RNF31	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TBK1	1	TXLNG	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Li S (2011), Li S (2011)	4
TXLNA	3	TXLNG	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Li S (2011), Li S (2011), Havugimana PC (2012), Huttlin EL (2017), Boldt K (2016)	7
CALCOCO2	0	MTPAP	2	affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
AZI2	1	TXLNG	1	affinity chromatography technology	Li S (2011)	1
CALCOCO2	0	TBKBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thurston TL (2009), Li S (2011), Huttlin EL (2017)	3
HIF1AN	0	TBK1	1	affinity chromatography technology	Huttlin EL (2017)	1
AZI2	1	TRAF3	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
HIF1AN	0	TXLNA	3	affinity chromatography technology	Huttlin EL (2017)	1
BBOX1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM107A	0	AZI2	1	two hybrid	Mu P (2017)	1
IKBKE	2	CALCOCO2	0	affinity chromatography technology	Thurston TL (2009)	1
EGLN3	0	TBK1	1	affinity chromatography technology	Rodriguez J (2016)	1
TBKBP1	2	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Ryzhakov G (2007), Ryzhakov G (2007)	3
BBOX1	0	AZI2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBK1	1	MTPAP	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
EGLN3	0	AZI2	1	affinity chromatography technology	Rodriguez J (2016)	1
BBOX1	0	TXLNA	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALCOCO2	0	FAM107A	0	two hybrid	Rual JF (2005)	1
TBK1	1	TBKBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Li S (2011), Li S (2011), Ryzhakov G (2007), Ryzhakov G (2007), Ryzhakov G (2007), Seo S (2013), Richter B (2016)	8
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
TBK1	1	TXLNA	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Li S (2011), Li S (2011), Li S (2011), Li S (2011), Huttlin EL (2017)	5
TBKBP1	2	APBA3	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
EGLN3	0	TXLNA	3	affinity chromatography technology	Rodriguez J (2016)	1
CALCOCO2	0	AZI2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
AZI2	1	MTPAP	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
BBOX1	0	CALCOCO2	0	affinity chromatography technology	Huttlin EL (2015)	1
AZI2	1	TBKBP1	2	affinity chromatography technology, affinity chromatography technology	Ryzhakov G (2007), Ryzhakov G (2007)	2
AZI2	1	APBA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
AZI2	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Li S (2011), Ryzhakov G (2007)	2
TBK1	1	CALCOCO2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Thurston TL (2009), Li S (2011), Li S (2011), Li S (2011), Li S (2011), Huttlin EL (2017)	6
HIF1AN	0	APBA3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2017), Sakamoto T (2009), Sakamoto T (2009), Sakamoto T (2009), Rodriguez J (2016)	5
HIF1AN	0	TXLNG	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM38	3	AZI2	1	affinity chromatography technology, affinity chromatography technology	Zhao W (2012), Zhao W (2012)	2
APBA3	2	TBK1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	APBA3	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TBKBP1	2	affinity chromatography technology	Rodriguez J (2016)	1
AZI2	1	AZI2	1	affinity chromatography technology	Ryzhakov G (2007)	1