PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
SCNN1B	1	NEDD4L	3	far western blotting, far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Harvey KF (2001), Rauh R (2006), Soundararajan R (2009), Itani OA (2003), Snyder PM (2004), Bhalla V (2006), Lott JS (2002), Itani OA (2005)	8
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
FKBP5	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
COMMD1	1	SGK1	4	affinity chromatography technology	Ke Y (2010)	1
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
SGK1	4	HSPA4	3	affinity chromatography technology	Belova L (2006)	1
PIK3CA	8	PDK1	1	protein complementation assay	Miao B (2010)	1
IKBKG	0	PPP2CA	7	affinity chromatography technology	Kray AE (2005)	1
HSPA4	3	NDRG1	2	affinity chromatography technology	Ambrosini G (2009)	1
YWHAZ	1	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
SGK1	4	CDC37	0	affinity chromatography technology	Ewing RM (2007)	1
RABAC1	0	SGK1	4	two hybrid	Wang J (2011)	1
NEDD4	2	SGK1	4	pull down, pull down, enzymatic study, affinity chromatography technology	Asher C (2003), Snyder PM (2002), Persaud A (2009), Wiemuth D (2010)	4
CDC37	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Li J (2013)	3
SGK1	4	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
SGK1	4	PIGR	4	affinity chromatography technology	Ewing RM (2007)	1
VCP	6	RAF1	3	affinity chromatography technology	Yu CC (2013)	1
CDC37	0	MTOR	14	two hybrid	Vinayagam A (2011)	1
HSP90AA1	7	SGK1	4	affinity chromatography technology	Taipale M (2012)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
PDPK1	0	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology	Chun J (2002), Chun J (2002)	2
YWHAQ	0	WNK4	5	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
PA2G4	1	IKBKG	0	two hybrid	Ravasi T (2010)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
SGK1	4	YWHAZ	1	affinity chromatography technology	Chun J (2004)	1
PIN1	0	PPP2CA	7	biochemical	Havugimana PC (2012)	1
SGK1	4	IARS	5	affinity chromatography technology	Ewing RM (2007)	1
SGK1	4	RAP2A	0	affinity chromatography technology	Huttlin EL (2015)	1
VCP	6	CDKN1B	1	affinity chromatography technology	Yu CC (2013)	1
CD40	3	SGK1	4	affinity chromatography technology	Ewing RM (2007)	1
SGK1	4	TUFM	1	affinity chromatography technology	Ewing RM (2007)	1
SGK1	4	MAGEA1	0	two hybrid	Pilot-Storck F (2010)	1
GADD45G	0	SGK1	4	two hybrid	Wang J (2011)	1
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
HSP90AA1	7	WNK4	5	affinity chromatography technology	Taipale M (2012)	1
SGK1	4	MAPT	1	enzymatic study, enzymatic study	Virdee K (2007), Chun J (2004)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RPTOR	4	HSPA4	3	affinity chromatography technology	Jacinto E (2006)	1
TSC22D3	1	SCNN1B	1	affinity chromatography technology	Soundararajan R (2009)	1
NEDD4	2	RAF1	3	pull down	Persaud A (2009)	1
TRIM25	5	PPP2CA	7	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	NDRG1	2	affinity chromatography technology	Choudhury NR (2017)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
PIN1	0	CDKN1B	1	pull down, affinity chromatography technology, unspecified method	Zhou W (2009), Zhou W (2009), Zhou W (2009)	3
YWHAZ	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
CDKN1B	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Fujita N (2002), Rosner M (2007)	2
NEDD4	2	CAMKK2	3	pull down	Persaud A (2009)	1
SGK1	4	HRAS	2	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
MAPT	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chun J (2004), Chun J (2004)	2
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
TUFM	1	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
VCP	6	MTOR	14	affinity chromatography technology	Yu CC (2013)	1
RPTOR	4	AKT1S1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gwinn DM (2010), Sancak Y (2007), Peterson TR (2009), Thedieck K (2007), Hong F (2008), Vander Haar E (2007), Thedieck K (2007)	7
MAPK7	1	RAF1	3	affinity chromatography technology, pull down	English JM (1999), English JM (1999)	2
TRIM25	5	CAMKK2	3	affinity chromatography technology	Choudhury NR (2017)	1
SLC9A3R2	8	SGK1	4	pull down, pull down, enzymatic study, pull down, affinity chromatography technology	Chun J (2002), Chun J (2002), Chun J (2002), Yun CC (2002), Yun CC (2002)	5
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chandran S (2011), Ichimura T (2013)	2
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
YWHAQ	0	WNK1	7	affinity chromatography technology	Ichimura T (2013)	1
HSPA4	3	PA2G4	1	affinity chromatography technology, far western blotting	Ko HR (2014), Hwang I (2016)	2
HRAS	2	RAF1	3	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Stang S (1997), Germani A (2003), Mitin NY (2004), Vargiu P (2004), Yuryev A (2003), Li W (2000), Li W (2000), Kiyono M (2000), Janoueix-Lerosey I (1998), Boettner B (2000), Karbowniczek M (2006), Han L (1995), Jelinek T (1994), Romero F (1999), Morcos P (1996), Hu CD (1995), Hu CD (1995), Rodriguez-Viciana P (1997), Huang YZ (2003), Stang S (1997), Dougherty MK (2005), Ji H (2016), Fridman M (2000), Ivanov AA (2017)	24
TRIM25	5	COMMD1	1	affinity chromatography technology	Choudhury NR (2017)	1
YWHAZ	1	WNK2	5	two hybrid	Bandyopadhyay S (2010)	1
SLC9A3R2	8	HRAS	2	biochemical	Havugimana PC (2012)	1
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
YWHAQ	0	AKT1S1	1	affinity chromatography technology, pull down	Ichimura T (2013), Meek SE (2004)	2
SGK1	4	LTF	2	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	TSC22D3	1	affinity chromatography technology	Matsumoto M (2005)	1
FANCA	5	SGK1	4	two hybrid	Reuter TY (2003)	1
COMMD1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	van de Sluis B (2009), van de Sluis B (2009)	2
MTOR	14	YWHAZ	1	affinity chromatography technology, genetic interference	Vander Haar E (2007), Srivas R (2016)	2
RICTOR	4	MAPKAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jacinto E (2006), Yang Q (2006), Jacinto E (2006), Pearce LR (2007), Pearce LR (2007), Gao D (2010), Gao D (2010), Oh WJ (2010), Oh WJ (2010), Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Ikenoue T (2008), Murata H (2011), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Martin J (2008), Thedieck K (2007), Hong F (2008), Facchinetti V (2008), Chen CH (2011), Glidden EJ (2012), Thedieck K (2007)	24
HSPA4	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Martin J (2008), Martin J (2008)	2
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
PIK3CA	8	SGK1	4	pull down	Park J (1999)	1
YWHAQ	0	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Yeung K (2000), Van Der Hoeven PC (2000), Liu YC (1996), Subramanian RR (2001), ONeill E (2004), Rajalingam K (2005), Zhu J (2005), Bonnefoy-Berard N (1995), So J (2015)	10
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
PIN1	0	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
IKBKG	0	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Chen G (2002), Taipale M (2014), Taipale M (2014), Liu D (2014), Hein MY (2015), Hein MY (2015), Li J (2013)	8
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
HSP90AA1	7	MAPK7	1	affinity chromatography technology	Taipale M (2012)	1
PDPK1	0	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Sato S (2002), Heo SR (2009)	2
SGK1	4	PIN1	0	affinity chromatography technology, affinity chromatography technology, pull down	Jo A (2015), Jo A (2015), Jo A (2015)	3
SGK1	4	WNK4	5	enzymatic study, affinity chromatography technology	Heise CJ (2010), Heise CJ (2010)	2
PDK1	1	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hara K (2002), Misra UK (2014), Misra UK (2014)	3
TRIM25	5	RAF1	3	affinity chromatography technology	Choudhury NR (2017)	1
RAP2A	0	MTOR	14	affinity chromatography technology	Thomas JD (2014)	1
TRIM25	5	MTOR	14	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	WNK2	5	affinity chromatography technology	Choudhury NR (2017)	1
KPNA2	0	SGK1	4	pull down, affinity chromatography technology, two hybrid	Maiyar AC (2003), Maiyar AC (2003), Maiyar AC (2003)	3
MAPK7	1	HSPA4	3	affinity chromatography technology	Erazo T (2013)	1
RPTOR	4	IKBKG	0	affinity chromatography technology	Dan HC (2008)	1
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CDC37	0	YWHAQ	0	affinity chromatography technology	Li J (2013)	1
ELAVL1	0	CDKN1B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
MTOR	14	AKT1S1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sancak Y (2007), Peterson TR (2009), Peterson TR (2009), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Hong F (2008), Toschi A (2009), Vander Haar E (2007)	9
SGK1	4	CDKN1B	1	enzymatic study	Hong F (2008)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
SGK1	4	RPTOR	4	affinity chromatography technology	Hong F (2008)	1
SGK1	4	ARL5B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
SGK1	4	NDRG1	2	enzymatic study	Garcia-Martinez JM (2009)	1
TRIM25	5	RPTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
MTOR	14	SGK1	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Hong F (2008), Hong F (2008), Hong F (2008)	3
NDRG1	2	RABAC1	0	affinity chromatography technology	Kim JT (2012)	1
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
WNK1	7	NEDD4L	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Heise CJ (2010), Heise CJ (2010), Roy A (2015), Roy A (2015)	4
HSP90AA1	7	CDKN1B	1	genetic interference	Srivas R (2016)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
TRIM25	5	AKT1S1	1	affinity chromatography technology	Choudhury NR (2017)	1
PPP2CA	7	SGK1	4	pull down	Park J (1999)	1
FANCA	5	HSP90AA1	7	two hybrid	Reuter TY (2003)	1
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
YWHAZ	1	WNK1	7	two hybrid	Bandyopadhyay S (2010)	1
COMMD1	1	SCNN1B	1	affinity chromatography technology, affinity chromatography technology	Ke Y (2010), Biasio W (2004)	2
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
VCP	6	YWHAQ	0	affinity chromatography technology	Yu CC (2013)	1
SCNN1B	1	NEDD4	2	pull down, pull down, far western blotting, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Persaud A (2009), Ke Y (2010), Snyder PM (2001), Kanelis V (2001)	7
STUB1	4	SGK1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soundararajan R (2010), Soundararajan R (2010), Belova L (2006)	3
SCNN1B	1	SGK1	4	affinity chromatography technology	Ke Y (2010)	1
IKBKG	0	HSPA4	3	affinity chromatography technology	Ammirante M (2010)	1
ELAVL1	0	RAP2A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RAF1	3	SCNN1B	1	affinity chromatography technology	Soundararajan R (2009)	1
MTOR	14	PDK1	1	genetic interference, affinity chromatography technology, affinity chromatography technology	Isotani S (1999), Misra UK (2014), Misra UK (2014)	3
SGK1	4	PCCA	0	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	WNK1	7	affinity chromatography technology	Choudhury NR (2017)	1
STUB1	4	VCP	6	affinity chromatography technology, pull down	Vij N (2006), Liu S (2013)	2
PIN1	0	MAPT	1	pull down, affinity chromatography technology	Lu PJ (1999), Ryo A (2006)	2
YWHAQ	0	MTOR	14	pull down	Meek SE (2004)	1
SGK1	4	ASPG	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Menniti M (2010), Menniti M (2010), Menniti M (2010), Menniti M (2010)	4
TRIM25	5	SGK1	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	KPNA2	0	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	GADD45G	0	pull down	Fenner BJ (2010)	1
NEDD4	2	RAP2A	0	pull down, pull down, affinity chromatography technology	Kawabe H (2010), Wang L (2017), Wang L (2017)	3
SGK1	4	SGK1	4	enzymatic study	Caohuy H (2014)	1
RAF1	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu J (2005), Zhu J (2005), Zhu J (2005), da Rocha Dias S (2005)	4
PIK3CA	8	HRAS	2	pull down, two hybrid, pull down	Vargiu P (2004), Li W (2000), Rodriguez-Viciana P (1996)	3
TRIM25	5	FKBP5	0	affinity chromatography technology	Choudhury NR (2017)	1
SGK1	4	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soundararajan R (2010), Soundararajan R (2009), Soundararajan R (2009)	3
MAPK7	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013)	2
SGK1	4	CAMKK2	3	affinity chromatography technology	Imai S (2003)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
MAPKAP1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Pearce LR (2007), Oh WJ (2010), Yang Q (2006), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Martin J (2008), Thedieck K (2007), Thedieck K (2007), Hong F (2008), Facchinetti V (2008), Facchinetti V (2008), Glidden EJ (2012), Vander Haar E (2007)	17
UBC	7	SGK1	4	pull down	Nathan JA (2013)	1
UBC	7	TUFM	1	affinity chromatography technology	Matsumoto M (2005)	1
YWHAQ	0	RPTOR	4	affinity chromatography technology	Gwinn DM (2008)	1
MTOR	14	PA2G4	1	pull down	Toral-Barza L (2005)	1
CD40	3	HSPA4	3	pull down, affinity chromatography technology	Becker T (2002), Becker T (2002)	2
NEDD4L	3	PIK3CA	8	enzymatic study	Wang Z (2016)	1
SGK1	4	PDPK1	0	pull down, pull down, enzymatic study	Chun J (2002), Park J (1999), Jung H (2007)	3
MTOR	14	RICTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Frias MA (2006), Jacinto E (2006), Yang Q (2006), Frias MA (2006), Sarbassov DD (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Guo Z (2012), Sarbassov DD (2006), Sancak Y (2007), Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Rosner M (2010), Ikenoue T (2008), Ikenoue T (2008), Murata H (2011), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Woods NT (2012), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Martin J (2008), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), McDonald PC (2008), McDonald PC (2008), Hong F (2008), Hong F (2008), Facchinetti V (2008), Toschi A (2009), Zhang F (2010), Chen CH (2011), Chen CH (2011), Xu Y (2013), Xu Y (2013), Glidden EJ (2012), Glidden EJ (2012), Vander Haar E (2007), Koo J (2015), Thedieck K (2007)	59
WNK2	5	SGK1	4	affinity chromatography technology	Heise CJ (2010)	1
PDK1	1	SGK1	4	enzymatic study	Seong HA (2007)	1
TSC22D3	1	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ayroldi E (2002), Ayroldi E (2002), Soundararajan R (2009), Soundararajan R (2009)	4
MAPKAP1	0	SGK1	4	pull down	Tatebe H (2017)	1
NDRG1	2	VCP	6	affinity chromatography technology	Tu LC (2007)	1
RICTOR	4	HSPA4	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Pearce LR (2007), Martin J (2008), Martin J (2008), Martin J (2008)	4
IKBKG	0	SGK1	4	pull down	Fenner BJ (2010)	1
PIN1	0	RAF1	3	affinity chromatography technology, affinity chromatography technology	Dougherty MK (2005), Dougherty MK (2005)	2
WNK4	5	NEDD4L	3	enzymatic study	Heise CJ (2010)	1
ELAVL1	0	RICTOR	4	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPT	1	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Dickey CA (2008), Hatakeyama S (2004), Hatakeyama S (2004), Hatakeyama S (2004), Petrucelli L (2004), Dolan PJ (2010), Dolan PJ (2010), Shimura H (2004), Shimura H (2004), Shimura H (2004), Dickey CA (2007), Sakagami Y (2013), Ozdemir AY (2013), Grelle G (2006), Grelle G (2006)	15
CD40	3	PIK3CA	8	affinity chromatography technology	Deregibus MC (2003)	1
SGK1	4	NEDD4L	3	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Nagaki K (2006), Heise CJ (2010), Wiemuth D (2010), Xu BE (2005), Lamothe S (2013), Gao S (2009)	6
VCP	6	CDC37	0	affinity chromatography technology	Yu CC (2013)	1
AKT1S1	1	YWHAZ	1	affinity chromatography technology	Vander Haar E (2007)	1
SGK1	4	CARHSP1	1	pull down	Auld GC (2005)	1
RAF1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stancato LF (1993), Dogan T (2008), Mollapour M (2010), Du J (2006), Maloney A (2007), Fiskus W (2007), Giommarelli C (2010), Arlander SJ (2006), ONeill E (2004), Taipale M (2012), Zhu J (2005), Schneider C (1996), Mollapour M (2014), Atabakhsh E (2012), Mitra S (2016)	15
CDC37	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
SGK1	4	RICTOR	4	affinity chromatography technology, enzymatic study	Gao D (2010), Gao D (2010)	2
SGK1	4	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chun J (2004), Chun J (2004)	2
MAPK7	1	SGK1	4	two hybrid, pull down, enzymatic study	Hayashi M (2001), Hayashi M (2001), Hayashi M (2001)	3
RAF1	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study	Dogan T (2008), Dogan T (2008), Alberti S (2004), Westhoff B (2005), Dreiseidler M (2012)	5
TSC22D3	1	NEDD4L	3	affinity chromatography technology	Soundararajan R (2009)	1
TRIM25	5	IARS	5	affinity chromatography technology	Choudhury NR (2017)	1
MAPK7	1	YWHAZ	1	affinity chromatography technology	Erazo T (2013)	1
SGK1	4	AKT1S1	1	affinity chromatography technology	Hong F (2008)	1
ELAVL1	0	TSC22D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	LTF	2	pull down	Nathan JA (2013)	1
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
SGK1	4	MYH14	10	affinity chromatography technology	Huttlin EL (2015)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
WNK1	7	SGK1	4	affinity chromatography technology, affinity chromatography technology	Heise CJ (2010), Xu BE (2005)	2
UBC	7	IARS	5	affinity chromatography technology	Matsumoto M (2005)	1
VCP	6	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Ohama T (2010), Yakovlev VA (2013)	2
HSP90AA1	7	CAMKK2	3	affinity chromatography technology	Taipale M (2012)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
SGK1	4	PA2G4	1	affinity chromatography technology	Ewing RM (2007)	1
RPTOR	4	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Rosner M (2010), Rosner M (2010)	2
VCP	6	COMMD1	1	affinity chromatography technology	Yu CC (2013)	1
VCP	6	YWHAZ	1	affinity chromatography technology, two hybrid	Yu CC (2013), Wang J (2011)	2
MAPT	1	UBC	7	affinity chromatography technology	Mesco ER (1991)	1
PDPK1	0	PA2G4	1	affinity chromatography technology	Behrends C (2010)	1
SGK1	4	TMEM184C	1	two hybrid	Wang J (2011)	1
MAPT	1	HSPA4	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Petrucelli L (2004), Kawakami F (2011), Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012)	5
SGK1	4	TSC22D3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soundararajan R (2010), Soundararajan R (2010), Soundararajan R (2009), Soundararajan R (2009)	4
STUB1	4	PA2G4	1	affinity chromatography technology, far western blotting	Ko HR (2014), Hwang I (2016)	2
SGK1	4	MLLT3	0	enzymatic study	Zhang W (2007)	1
SGK1	4	SYVN1	2	affinity chromatography technology	Soundararajan R (2010)	1
NDRG1	2	HSP90AA1	7	affinity chromatography technology	Tu LC (2007)	1
NEDD4L	3	RAF1	3	affinity chromatography technology, affinity chromatography technology	Soundararajan R (2009), Soundararajan R (2009)	2
HSPA4	3	FKBP5	0	affinity chromatography technology	Schuelke JP (2010)	1
MAPT	1	YWHAZ	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Hashiguchi M (2000), Hashiguchi M (2000), Chun J (2004), Sluchanko NN (2009), Sluchanko NN (2009)	5
MTOR	14	IKBKG	0	affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008)	2
WNK1	7	WNK2	5	two hybrid	Bandyopadhyay S (2010)	1
RAF1	3	PPP2CA	7	affinity chromatography technology	Rajalingam K (2005)	1
TRIM25	5	RICTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
SGK1	4	FKBP5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SGK1	4	3493	0	affinity chromatography technology	Ewing RM (2007)	1
ELAVL1	0	SGK1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
VCP	6	WNK1	7	affinity chromatography technology	Yu CC (2013)	1