PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SH3GL2	1	CLEC3B	0	two hybrid	Vinayagam A (2011)	1
ITSN1	5	SYNJ1	3	affinity chromatography technology	Tsyba L (2008)	1
SH3GL2	1	ZNF580	1	two hybrid	Vinayagam A (2011)	1
SYNM	3	AMPH	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anggono V (2007), Slepnev VI (2000), David C (1996)	3
ERH	0	APP	1	pull down	Olah J (2011)	1
LRRK2	5	CALM1	0	affinity chromatography technology	Meixner A (2011)	1
EGFL6	1	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3GL2	1	ADAM15	2	two hybrid, pull down, affinity chromatography technology	Howard L (1999), Howard L (1999), Howard L (1999)	3
ITCH	1	PDCD6IP	3	affinity chromatography technology	OConnor HF (2015)	1
SH3GL2	1	GSTM3	1	two hybrid	Vinayagam A (2011)	1
ZXDC	1	APP	1	pull down	Olah J (2011)	1
DPPA4	0	SH3GL1	3	two hybrid, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Vinayagam A (2011), Stelzl U (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Oliviero G (2015), Huttlin EL (2017)	9
ARNT2	5	APP	1	pull down	Olah J (2011)	1
SH3GL1	3	SH3GL3	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Ralser M (2005), Huttlin EL (2015), Huttlin EL (2017)	7
LCP2	0	APP	1	pull down	Olah J (2011)	1
ARHGAP8	0	SH3GL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYNM	3	SH3GL2	1	affinity chromatography technology	Anggono V (2007)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
CD2AP	0	SH3GL2	1	affinity chromatography technology, far western blotting	Lynch DK (2003), Lynch DK (2003)	2
LRRK2	5	PTPN23	7	two hybrid	Zheng XY (2008)	1
HLA-DQA1	1	SH3GL2	1	two hybrid	Stelzl U (2005)	1
PTPN23	7	SH3GL2	1	two hybrid, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007)	2
ARNT2	5	SH3GL2	1	two hybrid	Wang J (2011)	1
DPPA4	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
EMD	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3GL2	1	LCP2	0	two hybrid	Vinayagam A (2011)	1
DPYSL4	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
CALM1	0	SH3GL1	3	affinity chromatography technology	Myers MD (2016)	1
SH3GL3	1	DNM3	3	affinity chromatography technology	Nonis D (2008)	1
APP	1	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	EMD	0	biochemical, affinity chromatography technology, affinity chromatography technology	Wang YN (2010), Tong J (2014), Yao Z (2017)	3
CLEC3B	0	APP	1	pull down	Olah J (2011)	1
SH3GL2	1	ADAM19	6	two hybrid	Howard L (1999)	1
SH3GL2	1	CBL	7	affinity chromatography technology	Soubeyran P (2002)	1
SH3GL2	1	DACT1	3	two hybrid	Vinayagam A (2011)	1
CBL	7	SH3GL3	1	affinity chromatography technology	Petrelli A (2002)	1
LRRK2	5	ACTG1	5	affinity chromatography technology	Meixner A (2011)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
DNM1	21	ITSN1	5	pull down, affinity chromatography technology	Solomaha E (2005), Tsyba L (2008)	2
CD2AP	0	EGFR	5	affinity chromatography technology	Lynch DK (2003)	1
CALM1	0	SH3GL2	1	affinity chromatography technology	Myers MD (2016)	1
TERF1	1	AMPH	4	two hybrid	Lee OH (2011)	1
DYRK1A	36	APP	1	pull down	Olah J (2011)	1
SH3GL2	1	APP	1	pull down	Olah J (2011)	1
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
SH3KBP1	1	DNM1	21	affinity chromatography technology	Havrylov S (2009)	1
SH3GL2	1	DLGAP4	4	two hybrid	Vinayagam A (2011)	1
LRRK2	5	SH3GL2	1	enzymatic study	Matta S (2012)	1
SH3GL3	1	FBXO32	2	affinity chromatography technology, pull down, imaging technique	Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016)	3
AMPH	4	ITSN1	5	affinity chromatography technology	Dergai M (2011)	1
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
EGFR	5	ATXN2	3	affinity chromatography technology, affinity chromatography technology	Nonis D (2008), Nonis D (2008)	2
SYNJ1	3	SH3GL1	3	unspecified method	Cestra G (1999)	1
DNM2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SH3GL2	1	FBXO32	2	affinity chromatography technology, pull down, pull down, imaging technique	Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016)	4
SH3GL2	1	ITCH	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, unspecified method	Angers A (2004), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	7
SH3GL2	1	F13A1	3	two hybrid	Vinayagam A (2011)	1
TERF1	1	SH3GL3	1	two hybrid	Stelzl U (2005)	1
ACTG1	5	SH3GL2	1	two hybrid	Stelzl U (2005)	1
EGFR	5	DNM2	2	affinity chromatography technology	Tong J (2014)	1
ITCH	1	LRRK2	5	affinity chromatography technology	OConnor HF (2015)	1
PAXIP1	1	EMD	0	affinity chromatography technology	Woods NT (2012)	1
TERF1	1	SH3GL2	1	two hybrid	Lee OH (2011)	1
SH3GL3	1	ATXN2	3	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Nonis D (2008), Nonis D (2008), Lim J (2006), Ralser M (2005), Ralser M (2005), Ralser M (2005), Nonis D (2008), Nonis D (2008), Nonis D (2008)	9
SH3GL3	1	SH3KBP1	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Petrelli A (2002), Petrelli A (2002), Petrelli A (2002), Vinayagam A (2011)	4
DNM2	2	ITSN1	5	two hybrid, pull down, pull down	Vinayagam A (2011), Solomaha E (2005), Elhamdani A (2006)	3
SH3GL2	1	DPPA4	0	two hybrid	Vinayagam A (2011)	1
SH3KBP1	1	ATXN2	3	affinity chromatography technology	Havrylov S (2009)	1
SH3GL2	1	ADAM9	0	two hybrid, pull down, affinity chromatography technology	Howard L (1999), Howard L (1999), Howard L (1999)	3
DYRK1A	36	AMPH	4	enzymatic study	Murakami N (2006)	1
PDCD6IP	3	CD2AP	0	affinity chromatography technology, affinity chromatography technology	Usami Y (2007), Morita E (2007)	2
DNM1	21	AMPH	4	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997), Wigge P (1997), McMahon HT (1997), Chen-Hwang MC (2002), Grabs D (1997), Solomaha E (2005), Stamenova SD (2007)	9
TCEA2	1	SH3GL2	1	two hybrid	Stelzl U (2005)	1
SH3GL2	1	MAST2	4	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
PAXIP1	1	SH3GL2	1	two hybrid	Soler-Lopez M (2011)	1
SH3GL1	3	DNM1	21	pull down	So CW (2000)	1
PDCD6IP	3	PTPN23	7	affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007)	2
EGFR	5	MAST2	4	affinity chromatography technology	Yao Z (2017)	1
SH3GL1	3	DPYSL4	0	two hybrid	Vinayagam A (2011)	1
DNM2	2	SH3GL2	1	pull down	Solomaha E (2005)	1
DNM3	3	DNM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IL6	0	SH3GL2	1	two hybrid	Stelzl U (2005)	1
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
EGFR	5	SH3GL3	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
DYRK1A	36	DNM1	21	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen-Hwang MC (2002), Murakami N (2009), Murakami N (2009), Murakami N (2009)	4
SH3GL2	1	SH3GL3	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Ralser M (2005), Huttlin EL (2015), Huttlin EL (2017)	6
EGFR	5	SH3GL2	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmidt MH (2004), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Liu W (2014), Liu W (2014)	6
TANGO2	0	SH3GL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYNM	3	CBL	7	affinity chromatography technology	Bruzzaniti A (2005)	1
EMD	0	DPPA4	0	two hybrid	Stelzl U (2005)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SH3KBP1	1	SH3GL2	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Soubeyran P (2002), Soubeyran P (2002), Soubeyran P (2002), Schmidt MH (2004), Schmidt MH (2004), Vinayagam A (2011)	6
DNM2	2	TIAM2	1	two hybrid	Vinayagam A (2011)	1
LRRK2	5	SH3GL1	3	enzymatic study	Matta S (2012)	1
PRR14	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CALM1	0	AMPH	4	affinity chromatography technology	Myers MD (2016)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
PDCD6IP	3	SH3GL1	3	affinity chromatography technology, two hybrid	Usami Y (2007), Wang J (2011)	2
ERH	0	SH3GL2	1	two hybrid	Stelzl U (2005)	1
AZU1	0	SH3GL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH3GL2	1	TMEM108	1	two hybrid	Vinayagam A (2011)	1
LRRK2	5	SH3GL3	1	enzymatic study	Matta S (2012)	1
SH3GL2	1	DNM1	21	pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Solomaha E (2005)	3
SH3KBP1	1	SYNJ1	3	affinity chromatography technology, far western blotting, affinity chromatography technology	Kurakin AV (2003), Kurakin AV (2003), Havrylov S (2009)	3
DNM3	3	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAXIP1	1	ERH	0	affinity chromatography technology	Woods NT (2012)	1
SH3GL2	1	TYMS	0	two hybrid	Vinayagam A (2011)	1
EGFL6	1	SH3GL2	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
PDCD6IP	3	SH3GL2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2004), Ichioka F (2007), Ichioka F (2007)	4
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
SYNJ1	3	AMPH	4	pull down, affinity chromatography technology, unspecified method	Micheva KD (1997), Micheva KD (1997), Cestra G (1999)	3
EGFR	5	PRR14	3	affinity chromatography technology	Yao Z (2017)	1
CBL	7	ITSN1	5	far western blotting, two hybrid, affinity chromatography technology, affinity chromatography technology	Martin NP (2006), Thalappilly S (2008), Dergai M (2011), Tsyba L (2008)	4
SH3GL2	1	PRR14	3	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	ZNF219	3	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	DPYSL4	0	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	DYRK1A	36	affinity chromatography technology	Murakami N (2009)	1
MAST2	4	APP	1	pull down	Olah J (2011)	1
3507	0	APP	1	pull down	Olah J (2011)	1
DNM2	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schroeder B (2010), Schroeder B (2010), Havrylov S (2009), Wan C (2015)	4
SH3GL2	1	DNM3	3	affinity chromatography technology	Nonis D (2008)	1
ITCH	1	ITSN1	5	fluorescent resonance energy transfe, affinity chromatography technology	Desrochers G (2015), Desrochers G (2015)	2
TCEA2	1	APP	1	pull down	Olah J (2011)	1
ITCH	1	SH3GL1	3	unspecified method	Desrochers G (2017)	1
SH3KBP1	1	CD2AP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tossidou I (2010), Gaidos G (2007), Huttlin EL (2017)	3
SH3GL1	3	FBXO32	2	affinity chromatography technology, pull down, imaging technique	Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016)	3
PTPN23	7	EGFR	5	affinity chromatography technology	Ali N (2013)	1
SH3GL2	1	GCH1	0	two hybrid	Vinayagam A (2011)	1
EGFR	5	LCP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
AMPH	4	SH3GL2	1	pull down	Micheva KD (1997)	1
SH3GL2	1	PPP1R21	1	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	SH3GL2	1	two hybrid, affinity chromatography technology	Ralser M (2005), Ralser M (2005)	2
CALM1	0	CBL	7	affinity chromatography technology, affinity chromatography technology	Singh VK (2012), Singh VK (2012)	2
EGFR	5	CALM1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, pull down	Li H (2004), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Aifa S (2002)	5
ITSN1	5	PDCD6IP	3	two hybrid	Wong KA (2012)	1
SH3GL2	1	PPP6R1	4	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	ZXDC	1	two hybrid	Vinayagam A (2011)	1
AZU1	0	SH3GL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGAP8	0	SH3GL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
CBL	7	LCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Erdreich-Epstein A (1999), Chu J (1998), Shen M (2009)	4
SH3GL2	1	3507	0	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	SH3GL1	3	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
SH3GL2	1	TIAM2	1	two hybrid	Vinayagam A (2011)	1
CD2AP	0	DNM2	2	affinity chromatography technology	Lynch DK (2003)	1
SH3KBP1	1	ZNF219	3	two hybrid	Vinayagam A (2011)	1
DNM2	2	AMPH	4	pull down, pull down	Solomaha E (2005), Elhamdani A (2006)	2
SH3GL2	1	ATXN2	3	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Nonis D (2008), Nonis D (2008), Lim J (2006), Ralser M (2005), Ralser M (2005), Ralser M (2005), Nonis D (2008), Nonis D (2008), Nonis D (2008)	9
EGFR	5	PPP6R1	4	affinity chromatography technology	Foerster S (2013)	1
ARHGAP8	0	SH3GL3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IPO11	0	SH3GL2	1	biochemical	Havugimana PC (2012)	1
SH3KBP1	1	PDCD6IP	3	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Schmidt MH (2004), Rauch S (2011), Havrylov S (2009), Usami Y (2007), Ichioka F (2007), Ichioka F (2007), Schmidt MH (2005), Carlton JG (2008), Chen B (2000)	9
EGFR	5	IPO11	0	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
EMD	0	SH3GL2	1	two hybrid, pull down	Stelzl U (2005), Stelzl U (2005)	2
CD2AP	0	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Kirsch KH (2001), Kirsch KH (2001), Cormont M (2003), Lynch DK (2003), Tibaldi EV (2003), Bao M (2012), Yao B (2007), Selbach M (2006), Taipale M (2014), Taipale M (2014), Igloi Z (2015)	13
SYNJ1	3	SH3GL2	1	pull down, pull down, affinity chromatography technology	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997)	3