PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFL6	1	SH3GL3	1	two hybrid	Stelzl U (2005)	1
DPPA4	0	SH3GL1	3	two hybrid, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Vinayagam A (2011), Stelzl U (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Oliviero G (2015), Huttlin EL (2017)	9
CBLC	1	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
SH3GL1	3	SH3GL3	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Ralser M (2005), Huttlin EL (2015), Huttlin EL (2017)	7
ARHGAP8	0	SH3GL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPL35A	0	SH3GL3	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
DPPA4	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
EMD	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
FASLG	0	SH3GL3	1	unspecified method	Voss M (2009)	1
DPYSL4	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
FASLG	0	NCF1	2	unspecified method	Voss M (2009)	1
SH3GL3	1	DNM3	3	affinity chromatography technology	Nonis D (2008)	1
C11orf68	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3GL3	1	PIAS4	5	two hybrid	Goehler H (2004)	1
EGFR	5	EMD	0	biochemical, affinity chromatography technology, affinity chromatography technology	Wang YN (2010), Tong J (2014), Yao Z (2017)	3
CBLC	1	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography	Kim M (1999), Keane MM (1999), Keane MM (1999), Takeshita K (2012), Takeshita K (2012), Takeshita K (2012)	6
VIM	0	SH3GL1	3	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	CBL	7	affinity chromatography technology	Soubeyran P (2002)	1
SEPT8	1	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
CBL	7	SH3GL3	1	affinity chromatography technology	Petrelli A (2002)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
SH3KBP1	1	SEPT8	1	affinity chromatography technology	Havrylov S (2009)	1
AES	2	SH3GL3	1	two hybrid	Stelzl U (2005)	1
LRRK2	5	VIM	0	affinity chromatography technology, affinity chromatography technology	Daechsel JC (2007), Sen S (2009)	2
LRRK2	5	SH3GL2	1	enzymatic study	Matta S (2012)	1
SH3GL3	1	FBXO32	2	affinity chromatography technology, pull down, imaging technique	Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016)	3
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
EGFR	5	ATXN2	3	affinity chromatography technology, affinity chromatography technology	Nonis D (2008), Nonis D (2008)	2
SH3GL2	1	FBXO32	2	affinity chromatography technology, pull down, pull down, imaging technique	Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016)	4
TERF1	1	SH3GL3	1	two hybrid	Stelzl U (2005)	1
HTT	14	EGFR	5	affinity chromatography technology	Liu YF (1997)	1
PTPRO	3	SH3GL1	3	two hybrid	Vinayagam A (2011)	1
TERF1	1	SH3GL2	1	two hybrid	Lee OH (2011)	1
ARHGEF6	0	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
SH3GL3	1	ATXN2	3	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Nonis D (2008), Nonis D (2008), Lim J (2006), Ralser M (2005), Ralser M (2005), Ralser M (2005), Nonis D (2008), Nonis D (2008), Nonis D (2008)	9
SH3GL3	1	SH3KBP1	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Petrelli A (2002), Petrelli A (2002), Petrelli A (2002), Vinayagam A (2011)	4
PTPRO	3	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	DPPA4	0	two hybrid	Vinayagam A (2011)	1
TOE1	1	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3KBP1	1	ATXN2	3	affinity chromatography technology	Havrylov S (2009)	1
TNNT1	0	VIM	0	two hybrid	Vinayagam A (2011)	1
SHC3	1	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
CALCOCO1	2	SH3GL3	1	two hybrid	Stelzl U (2005)	1
C4orf17	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3GL1	3	DPYSL4	0	two hybrid	Vinayagam A (2011)	1
PIAS4	5	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
EGFR	5	SH3GL3	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
RER1	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3GL2	1	SH3GL3	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Ralser M (2005), Huttlin EL (2015), Huttlin EL (2017)	6
TERF1	1	ARHGDIA	3	two hybrid	Lee OH (2011)	1
EGFR	5	SH3GL2	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmidt MH (2004), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Liu W (2014), Liu W (2014)	6
EMD	0	DPPA4	0	two hybrid	Stelzl U (2005)	1
SEPT8	1	SH3GL1	3	two hybrid	Vinayagam A (2011)	1
ARHGDIA	3	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3KBP1	1	SH3GL2	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Soubeyran P (2002), Soubeyran P (2002), Soubeyran P (2002), Schmidt MH (2004), Schmidt MH (2004), Vinayagam A (2011)	6
LRRK2	5	SH3GL1	3	enzymatic study	Matta S (2012)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
NDUFB9	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
LRRK2	5	SH3GL3	1	enzymatic study	Matta S (2012)	1
CRIP1	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
VIM	0	PIAS4	5	two hybrid	Goehler H (2004)	1
NCF1	2	SH3GL3	1	affinity chromatography technology	Huttlin EL (2017)	1
FAM173A	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
EGFL6	1	SH3GL2	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
SH3GL3	1	SH3GL3	1	two hybrid, two hybrid, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005)	3
PTPRO	3	DPYSL4	0	two hybrid	Vinayagam A (2011)	1
ARHGEF6	0	CBL	7	affinity chromatography technology, affinity chromatography technology	Kortuem F (2015), Kortuem F (2015)	2
SH3GL2	1	DPYSL4	0	two hybrid	Vinayagam A (2011)	1
SH3GL2	1	DNM3	3	affinity chromatography technology	Nonis D (2008)	1
SH3GL1	3	FBXO32	2	affinity chromatography technology, pull down, imaging technique	Murdoch JD (2016), Murdoch JD (2016), Murdoch JD (2016)	3
CD101	4	SH3GL3	1	two hybrid	Stelzl U (2005)	1
CBL	7	VIM	0	affinity chromatography technology	Valiya Veettil M (2011)	1
HTT	14	DPPA4	0	two hybrid	Suter B (2013)	1
TNNT1	0	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
DPPA4	0	VIM	0	two hybrid	Stelzl U (2005)	1
SNRPN	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
ARHGAP8	0	SH3GL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	RER1	0	affinity chromatography technology	Tong J (2014)	1
SH3GL2	1	SH3GL1	3	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
PTPRO	3	DPPA4	0	two hybrid	Vinayagam A (2011)	1
SHC3	1	EGFR	5	affinity chromatography technology, unspecified method, pull down	Nakamura T (1998), Jones RB (2006), OBryan JP (1996)	3
QTRT1	4	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SH3GL2	1	ATXN2	3	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Nonis D (2008), Nonis D (2008), Lim J (2006), Ralser M (2005), Ralser M (2005), Ralser M (2005), Nonis D (2008), Nonis D (2008), Nonis D (2008)	9
ARHGAP8	0	SH3GL3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GABBR2	15	SH3GL3	1	two hybrid	Stelzl U (2005)	1
SNRPN	0	TOE1	1	affinity chromatography technology	Huttlin EL (2017)	1
WDR33	3	SH3GL3	1	two hybrid	Stelzl U (2005)	1
HTT	14	SH3GL3	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Sittler A (1998), Sittler A (1998), Sittler A (1998), Goehler H (2004)	4
ARHGDIA	3	FASLG	0	biochemical	Gajate C (2005)	1
EMD	0	SH3GL2	1	two hybrid, pull down	Stelzl U (2005), Stelzl U (2005)	2
SH3GL3	1	VIM	0	two hybrid	Goehler H (2004)	1