PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHBG	0	MT1G	0	two hybrid	Pope SN (2005)	1
SHBG	0	SHBG	0	two hybrid	Pope SN (2005)	1
SHBG	0	DES	1	two hybrid	Pope SN (2005)	1
SHBG	0	ACPP	1	two hybrid	Pope SN (2005)	1
SHBG	0	AP1B1	6	two hybrid	Pope SN (2005)	1
SHBG	0	APOBEC3C	3	two hybrid	Pope SN (2005)	1
SHBG	0	ATP5A1	0	two hybrid	Pope SN (2005)	1
SHBG	0	MPDU1	0	two hybrid	Pope SN (2005)	1
SHBG	0	CD177	1	two hybrid	Pope SN (2005)	1
FLNA	10	GNB2	3	affinity chromatography technology	Hein MY (2015)	1
SHBG	0	PLA2G4A	1	two hybrid	Pope SN (2005)	1
SHBG	0	HDHD5	0	two hybrid	Pope SN (2005)	1
SHBG	0	AP2A1	1	two hybrid	Pope SN (2005)	1
SHBG	0	SLC37A4	0	two hybrid	Pope SN (2005)	1
SHBG	0	EEF1A1	0	two hybrid	Pope SN (2005)	1
SHBG	0	DDX3Y	0	two hybrid	Pope SN (2005)	1
EEF1A1	0	PKM	1	biochemical	Wan C (2015)	1
FLNA	10	ACTB	8	affinity chromatography technology	Hein MY (2015)	1
SHBG	0	A2M	8	two hybrid	Pope SN (2005)	1
SHBG	0	PTGDS	0	two hybrid	Pope SN (2005)	1
SHBG	0	SNRNP70	2	two hybrid	Pope SN (2005)	1
SHBG	0	SRF	1	two hybrid	Pope SN (2005)	1
ACTB	8	DSTN	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
A2M	8	ACTB	8	two hybrid	Soler-Lopez M (2011)	1
GRB2	2	ACTB	8	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
GRB2	2	FLNA	10	affinity chromatography technology	Bisson N (2011)	1
SHBG	0	AK2	0	two hybrid	Pope SN (2005)	1
SHBG	0	TINAGL1	0	two hybrid	Pope SN (2005)	1
GRB2	2	AP2A1	1	affinity chromatography technology	Blagoev B (2003)	1
GRB2	2	A2M	8	two hybrid	Wang J (2008)	1
SHBG	0	COL1A2	1	two hybrid	Pope SN (2005)	1
SHBG	0	NOMO1	2	two hybrid	Pope SN (2005)	1
SHBG	0	MT2A	0	two hybrid	Pope SN (2005)	1
TINAGL1	0	GNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHBG	0	PKM	1	two hybrid	Pope SN (2005)	1
SHBG	0	DSTN	0	two hybrid	Pope SN (2005)	1
SHBG	0	UBE3A	4	two hybrid	Pope SN (2005)	1
AKR1B1	0	SORD	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SHBG	0	MT1F	0	two hybrid	Pope SN (2005)	1
SHBG	0	CNTNAP3B	8	affinity chromatography technology	Huttlin EL (2017)	1
SHBG	0	FLOT1	0	two hybrid	Pope SN (2005)	1
SHBG	0	PLP2	0	two hybrid	Pope SN (2005)	1
SHBG	0	AKR1B1	0	two hybrid	Pope SN (2005)	1
SHBG	0	KLK4	0	two hybrid	Pope SN (2005)	1
GRB2	2	SHBG	0	two hybrid	Wang J (2008)	1
SHBG	0	RMND5B	0	two hybrid	Pope SN (2005)	1
DES	1	SNRNP70	2	biochemical	Havugimana PC (2012)	1
SHBG	0	APOD	0	two hybrid	Pope SN (2005)	1
SHBG	0	SRI	1	two hybrid	Pope SN (2005)	1
SHBG	0	HYI	0	two hybrid	Pope SN (2005)	1
SHBG	0	PACSIN2	0	two hybrid	Pope SN (2005)	1
SHBG	0	AZGP1	3	two hybrid	Pope SN (2005)	1
SHBG	0	ACTB	8	two hybrid	Pope SN (2005)	1
SHBG	0	SORD	2	two hybrid	Pope SN (2005)	1
SHBG	0	GNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
SHBG	0	ASB16-AS1	0	two hybrid	Pope SN (2005)	1
CLEC4G	0	SHBG	0	two hybrid	Wang J (2008)	1
SHBG	0	APEH	2	two hybrid	Pope SN (2005)	1
PSTPIP1	3	ACTB	8	affinity chromatography technology	Linkermann A (2009)	1
SHBG	0	SEMA3F	4	two hybrid	Pope SN (2005)	1
SHBG	0	PSTPIP1	3	two hybrid	Pope SN (2005)	1
AP2A1	1	AP1B1	6	biochemical	Wan C (2015)	1
SHBG	0	ACTG2	0	two hybrid	Pope SN (2005)	1
TMEM236	0	SHBG	0	affinity chromatography technology	Huttlin EL (2017)	1
ATP5A1	0	FLOT1	0	biochemical	Havugimana PC (2012)	1
SHBG	0	EIF3E	1	two hybrid	Pope SN (2005)	1
UBE3A	4	ACTA2	1	pull down	Kapoor I (2015)	1
SHBG	0	CTSD	0	two hybrid	Pope SN (2005)	1
UBE3A	4	ACTB	8	pull down	Kapoor I (2015)	1
SHBG	0	FLNA	10	two hybrid	Pope SN (2005)	1
FLNA	10	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
SHBG	0	MXD4	3	two hybrid	Pope SN (2005)	1
SHBG	0	ACTA2	1	two hybrid	Pope SN (2005)	1
SHBG	0	CLDN4	1	two hybrid	Pope SN (2005)	1
SHBG	0	UBE2O	5	two hybrid	Pope SN (2005)	1
FLNA	10	FLOT1	0	affinity chromatography technology	Hein MY (2015)	1
ACTB	8	EEF1A1	0	biochemical	Wan C (2015)	1
SHBG	0	FYTTD1	2	two hybrid	Pope SN (2005)	1