Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
SHMT1	6470	GLYCINE	CHEMBL773		DrugBank	17664250, 17150100, 17142057, 16876889, 17355947
SHMT1	6470	PYRIDOXAL PHOSPHATE	CHEMBL82202	cofactor	DrugBank	17139284, 17016423, 3143355, 7526359, 10592235, 9305893
SHMT1	6470	CHEMBL1236268	CHEMBL1236268		DrugBank	17139284, 17016423, 10592235
SHMT1	6470	TETRAHYDROFOLATE	CHEMBL2074655	cofactor	DrugBank	11386852, 12668769, 11752472, 10998057, 10592235, 10656824
SHMT1	6470	BEVACIZUMAB	CHEMBL1201583		PharmGKB
SHMT1	6470	FLUOROURACIL	CHEMBL185		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
SHMT1	rs1979277	A	methotrexate	efficacy	no		Allele A is not associated with response to methotrexate in people with Arthritis, Rheumatoid.	22450926	827863356
SHMT1	rs1979277	A	bevacizumab	efficacy	yes		Allele A is associated with increased response to bevacizumab, fluorouracil, irinotecan and leucovorin in people with Colorectal Neoplasms as compared to allele G.	22044939	827815502
SHMT1	rs1979277	A	folic acid	efficacy	no		Allele A is not associated with response to folic acid, hydroxychloroquine, methotrexate and sulfasalazine in people with Arthritis, Rheumatoid.	18322994	769171254
SHMT1	rs1979277	AA	methotrexate	efficacy	no	Genotype AA is associated with increased red blood cell folate when treated with methotrexate as compared to genotype GG but this did not correlate with disease activity or red blood cell methotrexate metabolites.	Genotype AA is not associated with response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype GG.	20386493	1448107619