PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPARG	0	PDIA2	3	pull down	Agostini M (2006)	1
GAPDH	0	PDIA2	3	pull down	Liang Y (2001)	1
CUL3	17	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
ERO1B	1	PDIA2	3	affinity chromatography technology	Appenzeller-Herzog C (2010)	1
SNCA	0	PDIA2	3	pull down	Ranjan P (2016)	1
P4HA3	3	PDIA2	3	affinity chromatography technology, affinity chromatography technology	Kukkola L (2003), Kukkola L (2003)	2
PDIA2	3	COL2A1	9	pull down	Lumb RA (2002)	1
PDIA2	3	SST	0	pull down	Koivunen P (2005)	1
SYVN1	2	PDIA2	3	affinity chromatography technology	Bernardi KM (2010)	1
CUL3	17	PDIA2	3	two hybrid	Cummings CM (2009)	1
AMFR	2	PDIA2	3	affinity chromatography technology	Bernardi KM (2010)	1
TAP1	0	PDIA2	3	affinity chromatography technology, affinity chromatography technology	Park B (2006), Park B (2006)	2
CD3D	0	AMFR	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Chen B (2006)	2
SNCA	0	GAPDH	0	two hybrid, pull down	Vinayagam A (2011), Tsuchiya K (2005)	2
PDIA2	3	HM13	0	affinity chromatography technology	Lee SO (2010)	1
CD3D	0	PDIA2	3	affinity chromatography technology	Lee SO (2010)	1
LRP1	25	PDIA2	3	affinity chromatography technology	Orlando RA (2004)	1
PDIA2	3	P4HTM	0	pull down	Lumb RA (2002)	1
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
ERO1B	1	ERO1A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDIA2	3	MTTP	3	affinity chromatography technology	Miller SA (2014)	1
PDIA2	3	ERO1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benham AM (2000), Appenzeller-Herzog C (2010), Zhang L (2014)	3