PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMYD3	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hamamoto R (2004), Hamamoto R (2004), Huttlin EL (2015), Huttlin EL (2017)	4
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
730211	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
SMYD3	0	HIST3H3	0	enzymatic study	Hamamoto R (2004)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
EED	1	HSP90AB1	2	affinity chromatography technology	Cao Q (2014)	1
730211	0	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
EED	1	5430	0	affinity chromatography technology	Cao Q (2014)	1
ESR1	0	SMYD3	0	pull down, affinity chromatography technology, affinity chromatography technology	Kim H (2009), Kim H (2009), Kim H (2009)	3
HNRNPL	3	CAMK2B	9	affinity chromatography technology	Fei T (2017)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
SMYD3	0	MAGED4B	0	affinity chromatography technology	Huttlin EL (2015)	1
SMYD3	0	VANGL1	2	two hybrid	Wang J (2011)	1
EZH2	4	HIST3H3	0	enzymatic study, enzymatic study, enzymatic study	Sneeringer CJ (2010), Yap DB (2011), Cao Q (2014)	3
CAMK2B	9	SMYD3	0	two hybrid	Wang J (2011)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
ESR1	0	HSP90AB1	2	affinity chromatography technology	Dhamad AE (2016)	1
NFYB	2	SMYD3	0	two hybrid	Wang J (2011)	1
EED	1	HIST3H3	0	unspecified method, x-ray crystallography	Xu C (2010), Xu C (2010)	2
SMYD3	0	5430	0	affinity chromatography technology, affinity chromatography technology	Hamamoto R (2004), Hamamoto R (2004)	2
EED	1	SMYD3	0	unspecified method	Guil S (2012)	1
NDUFAB1	0	SMYD3	0	two hybrid	Wang J (2011)	1
SMYD3	0	APP	1	pull down	Olah J (2011)	1
ESR1	0	EZH2	4	pull down, affinity chromatography technology, affinity chromatography technology	Shi B (2007), Shi B (2007), Shi B (2007)	3
HIST3H3	0	HSP90AA1	7	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
HSP90AA1	7	CAMK2B	9	affinity chromatography technology	Taipale M (2012)	1
HELZ	6	SMYD3	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Hamamoto R (2004), Hamamoto R (2004), Hamamoto R (2004)	3
CDC37	0	SMYD3	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ZNF557	3	SMYD3	0	two hybrid	Weimann M (2013)	1
SMYD3	0	730211	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MEST	2	APP	1	pull down	Olah J (2011)	1
TRMT2A	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PLCB3	1	SMYD3	0	biochemical	Wan C (2015)	1
SMYD3	0	3327	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIT1	0	SMYD3	0	two hybrid	Weimann M (2013)	1
RCAN3	0	SMYD3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRMT2A	4	SMYD3	0	biochemical	Wan C (2015)	1
3327	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
KMT2E	7	SMYD3	0	affinity chromatography technology	Ding X (2015)	1
H3F3C	0	SMYD3	0	two hybrid	Weimann M (2013)	1
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
CYP39A1	1	SMYD3	0	two hybrid	Wang J (2011)	1
EED	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
EZH2	4	SMYD3	0	unspecified method, unspecified method	Guil S (2012), Guil S (2012)	2
HNRNPL	3	SMYD3	0	affinity chromatography technology	Fei T (2017)	1
ESR1	0	5430	0	affinity chromatography technology, imaging technique, imaging technique, pull down	Ambrosino C (2010), Zhang H (2006), Zhang H (2006), Nalvarte I (2010)	4
HIST3H3	0	HNRNPL	3	unspecified method	Vermeulen M (2010)	1
KDM3B	9	HIST3H3	0	enzymatic study	Kim JY (2012)	1
SMYD3	0	664618	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
SMYD3	0	KDM3B	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMYD3	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMYD3	0	MEST	2	affinity chromatography technology	Ewing RM (2007)	1