PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	TNS3	6	affinity chromatography technology	Kirli K (2015)	1
TNS3	6	DMD	6	affinity chromatography technology	St-Denis N (2016)	1
SNTB2	4	DMD	6	unspecified method, affinity chromatography technology, affinity chromatography technology	Ahn AH (1996), Johnson EK (2012), Huttlin EL (2017)	3
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
CFTR	5	XPO1	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
DMD	6	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
TNS3	6	PYCR2	1	affinity chromatography technology	St-Denis N (2016)	1
TRIM47	2	TNS3	6	biochemical	Kristensen AR (2012)	1
DNPEP	2	TNS3	6	biochemical	Kristensen AR (2012)	1
MOV10	6	TNS3	6	affinity chromatography technology	Castello A (2012)	1
MAT2B	0	XPO1	8	biochemical	Wan C (2015)	1
DMD	6	CTNNAL1	3	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TRIM25	5	TNS3	6	affinity chromatography technology	Choudhury NR (2017)	1
TNS3	6	DTNB	1	affinity chromatography technology	St-Denis N (2016)	1
CFTR	5	GANAB	8	affinity chromatography technology	Pankow S (2015)	1
NXF1	0	ERBB2	6	affinity chromatography technology	Castello A (2012)	1
CFTR	5	ENO1	3	affinity chromatography technology	Pankow S (2015)	1
XPO1	8	SNTB2	4	affinity chromatography technology	Kirli K (2015)	1
GANAB	8	PTPN12	2	biochemical	Kristensen AR (2012)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
CFTR	5	MOV10	6	affinity chromatography technology	Pankow S (2015)	1
TNS3	6	SNTB2	4	affinity chromatography technology	St-Denis N (2016)	1
ERBB3	3	TNS3	6	unspecified method	Jones RB (2006)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
EPHA4	3	TNS3	6	two hybrid	Yao Z (2017)	1
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
NXF1	0	TNS3	6	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	CTNNAL1	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
TNS3	6	UTRN	6	affinity chromatography technology	St-Denis N (2016)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
APOA1	0	TNS3	6	affinity chromatography technology	Zhou M (2004)	1
TNS3	6	CTNNAL1	3	affinity chromatography technology	St-Denis N (2016)	1
EGFR	5	PYCR2	1	affinity chromatography technology	Tong J (2014)	1
ERBB3	3	PTPN12	2	two hybrid	Yao Z (2017)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
GANAB	8	TNS3	6	biochemical	Kristensen AR (2012)	1
XPO1	8	DMD	6	affinity chromatography technology	Kirli K (2015)	1
SNTB1	1	DMD	6	pull down, pull down, affinity chromatography technology	Ahn AH (1995), Ahn AH (1995), Huttlin EL (2017)	3
ENO1	3	TNS3	6	affinity chromatography technology	Castello A (2012)	1
DMD	6	DTNB	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TRIM25	5	PTPN12	2	affinity chromatography technology	Choudhury NR (2017)	1
TNS3	6	SNTB1	1	affinity chromatography technology	St-Denis N (2016)	1
TNS3	6	PTPN12	2	biochemical	Kristensen AR (2012)	1
MAT2B	0	TNS3	6	biochemical	Havugimana PC (2012)	1
SRPK2	1	ERBB3	3	enzymatic study	Lipp JJ (2015)	1
TRIM47	2	PTPN12	2	biochemical	Kristensen AR (2012)	1
SNTB2	4	UTRN	6	unspecified method	Ahn AH (1996)	1
ERBB2	6	TNS3	6	unspecified method	Jones RB (2006)	1
TRIM25	5	ENO1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
SRPK2	1	NXF1	0	enzymatic study	Lipp JJ (2015)	1
PTPN12	2	UTRN	6	two hybrid	Colland F (2004)	1
CFTR	5	TNS3	6	affinity chromatography technology	Pankow S (2015)	1
ERBB2	6	XPO1	8	affinity chromatography technology, affinity chromatography technology	Giri DK (2005), Giri DK (2005)	2
TRIM47	2	GANAB	8	biochemical	Kristensen AR (2012)	1
EGFR	5	PTPN12	2	protein complementation assay, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Yao Z (2017)	5
TRIM25	5	DMD	6	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
TRIM47	2	DNPEP	2	biochemical	Kristensen AR (2012)	1
EGFR	5	TNS3	6	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
SRPK2	1	TNS3	6	enzymatic study	Lipp JJ (2015)	1
DNPEP	2	PTPN12	2	biochemical	Kristensen AR (2012)	1