PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GADD45A	1	MICAL1	0	two hybrid	Vinayagam A (2011)	1
SERHL2	1	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
IL1RL2	1	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	NCSTN	1	affinity chromatography technology	Emdal KB (2015)	1
USH1G	1	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	MICAL1	0	affinity chromatography technology	Emdal KB (2015)	1
GADD45A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
RAB10	1	MICAL1	0	two hybrid	Vinayagam A (2011)	1
SLC25A41	0	MICAL1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EHD1	5	MICAL1	0	pull down, two hybrid, two hybrid	Kieken F (2010), Kieken F (2010), Kieken F (2010)	3
NCSTN	1	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	PIK3R3	0	two hybrid	Grossmann A (2015)	1
ZNF517	0	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD9	3	ABL1	9	affinity chromatography technology, affinity chromatography technology	Minegishi M (1996), Law SF (1996)	2
NEDD9	3	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Minegishi M (1996), Ohashi Y (1998), Ohashi Y (1998), Ohashi Y (1998), Kanda H (1997)	5
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
GJB7	1	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
NCSTN	1	SRC	2	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	MICAL1	0	pull down	Suzuki T (2002)	1
ABL1	9	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study	Brehme M (2009), Brehme M (2009), Brehme M (2009), Peterson ME (2008), Yoshida K (2005), Chen C (2008), Feller SM (1994), Feller SM (1994), Bai RY (1998), Ren J (2002)	10
TAB1	1	MICAL1	0	two hybrid	Vinayagam A (2011)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
SLC25A41	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	VIM	0	two hybrid	Wang J (2011)	1
VIM	0	MICAL1	0	affinity chromatography technology	Suzuki T (2002)	1
PIK3R3	0	MICAL1	0	two hybrid	Vinayagam A (2011)	1
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
GSK3B	1	VIM	0	two hybrid	Vinayagam A (2011)	1
GRB2	2	TAB1	1	affinity chromatography technology	Bisson N (2011)	1
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
TAS2R7	1	MICAL1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASS4	2	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
GSK3B	1	MICAL1	0	two hybrid	Vinayagam A (2011)	1
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
CRK	0	MICAL1	0	pull down	Suzuki T (2002)	1
CRK	0	CASS4	2	affinity chromatography technology	Brehme M (2009)	1
SRC	2	MICAL1	0	pull down	Suzuki T (2002)	1
NTRK1	1	VIM	0	affinity chromatography technology	Emdal KB (2015)	1
ARHGAP26	3	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
ABL1	9	MICAL1	0	pull down	Suzuki T (2002)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
RPS6KA6	0	MICAL1	0	two hybrid	Vinayagam A (2011)	1
RAB1A	0	MICAL1	0	two hybrid, pull down	Weide T (2003), Weide T (2003)	2
NTRK1	1	EHD1	5	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
MICAL1	0	NEDD9	3	affinity chromatography technology, affinity chromatography technology, pull down	Suzuki T (2002), Suzuki T (2002), Suzuki T (2002)	3
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2