PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CNTROB	6	CEP192	5	bioid	Gupta GD (2015)	1
PSMC2	2	PSMA6	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MOV10	6	CEP85	5	affinity chromatography technology	Castello A (2012)	1
SPICE1	2	RPGRIP1L	2	bioid	Gupta GD (2015)	1
ODF2	1	CEP192	5	bioid	Gupta GD (2015)	1
TERF1	1	PSMA7	1	affinity chromatography technology	Giannone RJ (2010)	1
EYA2	2	CEP85	5	bioid	St-Denis N (2016)	1
CCDC14	2	SSX2IP	0	affinity chromatography technology	Hein MY (2015)	1
LATS2	1	CEP192	5	bioid	Couzens AL (2013)	1
RPGRIP1	6	PCM1	5	bioid	Gupta GD (2015)	1
RPGRIP1L	2	CEP85	5	bioid	Gupta GD (2015)	1
XPO1	8	CNTROB	6	affinity chromatography technology	Kirli K (2015)	1
CEP135	2	CEP152	2	bioid	Gupta GD (2015)	1
LATS2	1	CENPJ	6	bioid	Couzens AL (2013)	1
RPGRIP1L	2	CEP192	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	EWSR1	2	affinity chromatography technology	Akimov V (2011)	1
CLEC11A	0	CEP85	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCM1	5	CEP192	5	bioid	Gupta GD (2015)	1
MOV10	6	CENPJ	6	affinity chromatography technology	Castello A (2012)	1
PCM1	5	CEP85	5	bioid	Gupta GD (2015)	1
CENPJ	6	SSX2IP	0	bioid	Gupta GD (2015)	1
PLK4	1	CEP128	1	bioid	Firat-Karalar EN (2014)	1
STIL	3	SSX2IP	0	bioid	Gupta GD (2015)	1
KCMF1	0	CEP85	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBF1	2	CEP192	5	bioid	Gupta GD (2015)	1
CEP85	5	CEP44	2	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Huttlin EL (2017)	3
TERF1	1	CEP85	5	two hybrid	Lee OH (2011)	1
CENPJ	6	STIL	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
DEUP1	0	OFD1	3	bioid	Firat-Karalar EN (2014)	1
CENPJ	6	CEP192	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
XPO1	8	SOX13	4	affinity chromatography technology	Kirli K (2015)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
NXF1	0	CEP192	5	affinity chromatography technology	Castello A (2012)	1
PTTG1	0	CEP85	5	genetic interference	Vizeacoumar FJ (2013)	1
SAV1	0	CNTROB	6	bioid	Couzens AL (2013)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CEP85	5	SOX13	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP85	5	CEP85	5	affinity chromatography technology	Blomen VA (2015)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
CEP152	2	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
EWSR1	2	CEP85	5	bioid	Elzi DJ (2014)	1
SPICE1	2	CEP85	5	bioid	Gupta GD (2015)	1
CEP135	2	CEP192	5	bioid	Gupta GD (2015)	1
CEP63	2	SSX2IP	0	bioid	Gupta GD (2015)	1
XPO1	8	PTTG1	0	affinity chromatography technology	Kirli K (2015)	1
CEP85	5	PSMA6	1	affinity chromatography technology	Blomen VA (2015)	1
MOV10	6	CEP192	5	affinity chromatography technology	Castello A (2012)	1
WDYHV1	0	CEP85	5	affinity chromatography technology	Huttlin EL (2017)	1
CEP85	5	PSMA7	1	affinity chromatography technology	Blomen VA (2015)	1
NINL	1	CEP192	5	bioid	Gupta GD (2015)	1
CCDC14	2	CNTROB	6	bioid	Firat-Karalar EN (2014)	1
SPICE1	2	CEP44	2	bioid	Gupta GD (2015)	1
EYA2	2	CEP192	5	bioid	St-Denis N (2016)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
EGLN3	0	MASTL	5	affinity chromatography technology	Rodriguez J (2016)	1
DEUP1	0	CEP128	1	bioid	Firat-Karalar EN (2014)	1
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
PLK4	1	CEP192	5	bioid	Firat-Karalar EN (2014)	1
PCM1	5	RPGRIP1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP128	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CEP152	2	RPGRIP1L	2	bioid	Gupta GD (2015)	1
LATS2	1	NINL	1	bioid	Couzens AL (2013)	1
PSMA7	1	PSMB5	3	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
SSX2IP	0	OFD1	3	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
TRIM25	5	KCMF1	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
CEP63	2	CEP44	2	bioid	Gupta GD (2015)	1
TERF1	1	PSMB5	3	affinity chromatography technology	Giannone RJ (2010)	1
PLK4	1	STIL	3	bioid	Firat-Karalar EN (2014)	1
TRIM25	5	SOX13	4	affinity chromatography technology	Choudhury NR (2017)	1
CEP128	1	CEP192	5	bioid	Gupta GD (2015)	1
STIL	3	OFD1	3	bioid	Gupta GD (2015)	1
CNTROB	6	CEP85	5	bioid	Gupta GD (2015)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
XPO1	8	CEP85	5	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	ODF2	1	enzymatic study	Charlaftis N (2014)	1
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
CLEC11A	0	SAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MASTL	5	CEP85	5	affinity chromatography technology	Hein MY (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
DEUP1	0	CEP63	2	bioid	Firat-Karalar EN (2014)	1
LATS2	1	SPICE1	2	bioid	Couzens AL (2013)	1
PLK4	1	OFD1	3	bioid	Firat-Karalar EN (2014)	1
LATS2	1	OFD1	3	bioid	Couzens AL (2013)	1
TRIM25	5	CEP85	5	affinity chromatography technology	Choudhury NR (2017)	1
CEP192	5	CEP152	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
CEP85	5	PSMB5	3	affinity chromatography technology	Blomen VA (2015)	1
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
CENPJ	6	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
SAV1	0	LATS2	1	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Rashidian J (2015), Bae SJ (2015)	3
NXF1	0	CEP128	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	CENPJ	6	affinity chromatography technology	Castello A (2012)	1
CCDC14	2	CEP85	5	bioid	Firat-Karalar EN (2014)	1
PSMA6	1	PSMB5	3	two hybrid, biochemical, biochemical, biochemical	Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
EGLN3	0	CENPJ	6	affinity chromatography technology	Rodriguez J (2016)	1
CEP135	2	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
EGLN3	0	KCMF1	0	affinity chromatography technology	Rodriguez J (2016)	1
ODF2	1	OFD1	3	bioid	Gupta GD (2015)	1
EGLN3	0	STIL	3	affinity chromatography technology	Rodriguez J (2016)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
STIL	3	PCM1	5	bioid	Gupta GD (2015)	1
ODF2	1	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
NCAPH	2	CEP85	5	affinity chromatography technology	Hein MY (2015)	1
CEP85	5	SOX5	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEUP1	0	CEP85	5	bioid	Firat-Karalar EN (2014)	1
CEP135	2	CEP44	2	bioid	Gupta GD (2015)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CCDC14	2	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
DEUP1	0	CEP192	5	bioid	Firat-Karalar EN (2014)	1
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
SPICE1	2	SSX2IP	0	bioid	Gupta GD (2015)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP85	5	PSMC2	2	affinity chromatography technology	Blomen VA (2015)	1
SAV1	0	OFD1	3	bioid	Couzens AL (2013)	1
FBF1	2	PCM1	5	bioid	Gupta GD (2015)	1
CEP128	1	CEP85	5	bioid	Gupta GD (2015)	1
EGLN3	0	CEP192	5	affinity chromatography technology	Rodriguez J (2016)	1
PSMC2	2	PSMB5	3	affinity chromatography technology, biochemical, biochemical	Kim YC (2011), Havugimana PC (2012), Wan C (2015)	3
SAV1	0	PCM1	5	bioid	Couzens AL (2013)	1
NXF1	0	PSMC2	2	affinity chromatography technology	Castello A (2012)	1
CENPJ	6	OFD1	3	bioid	Gupta GD (2015)	1
SSX2IP	0	CEP85	5	bioid	Gupta GD (2015)	1
PCM1	5	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
STIL	3	CEP85	5	bioid	Gupta GD (2015)	1
NXF1	0	RPGRIP1L	2	affinity chromatography technology, bioid	Castello A (2012), Gupta GD (2015)	2
CEP192	5	CEP85	5	affinity chromatography technology, bioid	Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	2
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MASTL	5	PTTG1	0	genetic interference	Horlbeck MA (2018)	1
NINL	1	CENPJ	6	bioid	Gupta GD (2015)	1
NINL	1	OFD1	3	bioid	Gupta GD (2015)	1
NXF1	0	CEP85	5	affinity chromatography technology	Castello A (2012)	1
CEP192	5	OFD1	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	CEP44	2	bioid	Gupta GD (2015)	1
RPGRIP1L	2	SSX2IP	0	bioid	Gupta GD (2015)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
PCM1	5	CENPJ	6	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP192	5	CEP63	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
RPGRIP1	6	OFD1	3	bioid	Gupta GD (2015)	1
CNTROB	6	OFD1	3	bioid	Gupta GD (2015)	1
CEP63	2	OFD1	3	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
LATS2	1	SSX2IP	0	bioid	Couzens AL (2013)	1
CEP152	2	PCM1	5	bioid	Gupta GD (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
EGLN3	0	PCM1	5	affinity chromatography technology	Rodriguez J (2016)	1
CEP63	2	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP44	2	OFD1	3	bioid	Gupta GD (2015)	1
XPO1	8	KCMF1	0	affinity chromatography technology	Kirli K (2015)	1
CEP63	2	FBF1	2	two hybrid	Rolland T (2014)	1
TERF1	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
FBF1	2	OFD1	3	bioid	Gupta GD (2015)	1
NXF1	0	PSMB5	3	affinity chromatography technology	Castello A (2012)	1
CEP135	2	CEP85	5	bioid	Gupta GD (2015)	1
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
TRIM25	5	NCAPH	2	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	SAV1	0	affinity chromatography technology	Rodriguez J (2016)	1
PLK4	1	CEP85	5	bioid	Firat-Karalar EN (2014)	1
CEP128	1	CCDC14	2	bioid	Gupta GD (2015)	1
LATS2	1	PCM1	5	bioid	Couzens AL (2013)	1
EGLN3	0	NCAPH	2	affinity chromatography technology	Rodriguez J (2016)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	PSMC2	2	affinity chromatography technology	Rodriguez J (2016)	1
PLK4	1	CEP152	2	bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015)	3
PSMC2	2	XPO1	8	biochemical	Havugimana PC (2012)	1
PSMA6	1	PSMA7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, biochemical, biochemical, pull down	Apcher GS (2004), Apcher GS (2004), Apcher GS (2004), Apcher GS (2004), Jayarapu K (2004), Fricke B (2007), Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Ishii K (2015)	11
XPO1	8	SPICE1	2	affinity chromatography technology	Kirli K (2015)	1
FBF1	2	CEP85	5	bioid	Gupta GD (2015)	1
EGLN3	0	CEP85	5	affinity chromatography technology	Rodriguez J (2016)	1
ODF2	1	CEP44	2	bioid	Gupta GD (2015)	1
CEP63	2	CCDC14	2	two hybrid, bioid, bioid, affinity chromatography technology, bioid	Camargo LM (2007), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	5
EGLN3	0	SSX2IP	0	affinity chromatography technology	Rodriguez J (2016)	1
SAV1	0	CEP85	5	bioid	Couzens AL (2013)	1
PSMC2	2	PSMA7	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FBF1	2	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
MAP3K1	4	CEP85	5	enzymatic study	Charlaftis N (2014)	1
NINL	1	CEP85	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	CEP85	5	bioid	Gupta GD (2015)	1
CEP63	2	CEP152	2	bioid, bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	4
PLK4	1	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
CEP152	2	CENPJ	6	bioid	Firat-Karalar EN (2014)	1
XPO1	8	SSX2IP	0	affinity chromatography technology	Kirli K (2015)	1
FBF1	2	DEUP1	0	two hybrid	Rolland T (2014)	1
NINL	1	CCDC14	2	bioid	Gupta GD (2015)	1
CCDC14	2	OFD1	3	bioid, bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015), Hein MY (2015)	4
OFD1	3	CEP85	5	bioid	Gupta GD (2015)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MOV10	6	PSMB5	3	affinity chromatography technology	Castello A (2012)	1
PLK4	1	CEP63	2	bioid	Firat-Karalar EN (2014)	1
LATS2	1	CNTROB	6	bioid	Couzens AL (2013)	1
EWSR1	2	NINL	1	two hybrid	Rual JF (2005)	1
LATS2	1	CEP85	5	bioid	Couzens AL (2013)	1
DEUP1	0	CEP152	2	bioid	Firat-Karalar EN (2014)	1
SOX5	11	SOX13	4	affinity chromatography technology	Huttlin EL (2017)	1
SPICE1	2	CENPJ	6	bioid	Gupta GD (2015)	1
ODF2	1	CEP85	5	bioid	Gupta GD (2015)	1
CEP152	2	OFD1	3	bioid	Gupta GD (2015)	1
PCM1	5	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4