PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PINK1	2	COPS8	2	affinity chromatography technology	Choo YS (2012)	1
PINK1	2	PSMD1	2	affinity chromatography technology	Imai Y (2010)	1
MAP1LC3A	0	TOLLIP	3	affinity chromatography technology	Lu K (2014)	1
IRS4	2	HSPA4	3	affinity chromatography technology	Sano H (2002)	1
PRKN	1	TOMM70	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Okatsu K (2012), Sarraf SA (2013), Sarraf SA (2013), Bertolin G (2013), Bertolin G (2013), Bertolin G (2013), Zanon A (2013), Zanon A (2013), Bertolin G (2015)	9
IRAK1	1	BAG2	0	affinity chromatography technology	So J (2015)	1
TUBA1A	13	TUBB	3	biochemical, biochemical, pull down	Havugimana PC (2012), Kristensen AR (2012), Wang W (2014)	3
HSP90AB1	2	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PINK1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Lee HJ (2012), Murata H (2013)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
SARM1	3	IRAK1	1	affinity chromatography technology	Li S (2011)	1
PINK1	2	PINK1	2	enzymatic study, affinity chromatography technology, enzymatic study	Nakajima A (2003), Lazarou M (2012), Kondapalli C (2012)	3
PINK1	2	PGAM5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Imai Y (2010), Imai Y (2010), Imai Y (2010), Imai Y (2010)	4
SNCA	0	MAP1B	5	pull down	Jensen PH (2000)	1
FBXO7	1	MARK2	6	enzymatic study	Teixeira FR (2016)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
DNM1L	3	PSMC6	0	affinity chromatography technology	Malty RH (2017)	1
TOMM20	0	UBC	7	imaging technique	Michel MA (2017)	1
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
PRKN	1	TUBB	3	affinity chromatography technology	Zanon A (2013)	1
AKT1	1	MARK2	6	affinity chromatography technology, affinity chromatography technology	Dickey CA (2008), Dickey CA (2008)	2
TOMM20	0	TOMM40	1	affinity chromatography technology, biochemical, pull down	Lazarou M (2012), Havugimana PC (2012), Humphries AD (2005)	3
PINK1	2	HSD17B10	1	fluorescent resonance energy transfe	Bertolin G (2015)	1
TOMM40	1	BAG2	0	affinity chromatography technology	Hein MY (2015)	1
HSP90AB1	2	HSPA4	3	biochemical, affinity chromatography technology	Wan C (2015), Reidy M (2018)	2
MCL1	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Hollville E (2014), Hollville E (2014)	2
PINK1	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology	Lee HJ (2012), Lee HJ (2012)	2
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
SNCA	0	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kalia LV (2011), Huang C (2006), Huang C (2006), Lindersson E (2004), Kawakami F (2011), Pemberton S (2011), Klucken J (2006)	7
RHOT1	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Liu S (2012), Sun Y (2012), Sarraf SA (2013), Kumar A (2015), Ordureau A (2015), Kazlauskaite A (2015), Park S (2017), Kumar A (2017), Klosowiak JL (2016), Kazlauskaite A (2014)	10
HSP90AA1	7	PRKDC	12	affinity chromatography technology	Falsone SF (2005)	1
PARK7	0	MAP1B	5	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Z (2011), Wang Z (2011), Wang Z (2011), Wang Z (2011)	4
DNM1L	3	HSPA4	3	affinity chromatography technology	Malty RH (2017)	1
TOMM22	0	TOMM70	1	biochemical	Havugimana PC (2012)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
FBXO7	1	PINK1	2	affinity chromatography technology, pull down	Burchell VS (2013), Burchell VS (2013)	2
KRAS	1	NAE1	0	genetic interference	Luo J (2009)	1
FBXO7	1	PSMD1	2	affinity chromatography technology	Teixeira FR (2016)	1
SOCS4	0	PINK1	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MAP3K7	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu XY (2008), Jiang Z (2002), Jiang Z (2002), Lee HJ (2012), Yao J (2007)	5
BCL2L1	0	PINK1	2	affinity chromatography technology	Hollville E (2014)	1
HSD17B10	1	PSMD1	2	affinity chromatography technology	Malty RH (2017)	1
HSP90AA1	7	MCL1	1	genetic interference	Srivas R (2016)	1
PRKN	1	HSD17B10	1	pull down, enzymatic study, fluorescent resonance energy transfe	Bertolin G (2015), Bertolin G (2015), Bertolin G (2015)	3
TOMM40	1	TOMM70	1	biochemical	Havugimana PC (2012)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
PTEN	24	IRS4	2	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
PRKN	1	PGAM5	4	affinity chromatography technology	Zanon A (2013)	1
PGAM5	4	HSPA1B	1	two hybrid	Stelzl U (2005)	1
SNCAIP	2	PINK1	2	two hybrid	Bandopadhyay R (2005)	1
HSH2D	1	PINK1	2	two hybrid	Grossmann A (2015)	1
DNM1L	3	PARK7	0	affinity chromatography technology	Malty RH (2017)	1
HSPA4	3	PARK7	0	affinity chromatography technology, affinity chromatography technology	Moore DJ (2005), Deeg S (2010)	2
MCL1	1	TRAF6	0	affinity chromatography technology, pull down	Choi YB (2014), Choi YB (2014)	2
HSP90AA1	7	STAT3	0	affinity chromatography technology	Sato N (2003)	1
PARK7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2010), Zucchelli S (2010)	2
RHOT2	1	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
SNCA	0	AKT1	1	affinity chromatography technology, far western blotting	Chung JY (2011), Chung JY (2011)	2
MCL1	1	BCL2L1	0	affinity chromatography technology	Bae J (2000)	1
HSPA1A	0	TGM2	2	two hybrid	Wang J (2011)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
PSMD1	2	PSMD2	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
SNCAIP	2	SNCA	0	two hybrid, fluorescent resonance energy transfe, two hybrid, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neystat M (2002), Kawamata H (2001), Engelender S (1999), Engelender S (1999), Engelender S (1999), Xie YY (2010), Xie YY (2010), Smith WW (2005), Smith WW (2005), Bandopadhyay R (2005), Lee G (2004), Ryo A (2006), Ryo A (2006), Norris KL (2015), Nagano Y (2001)	15
PINK1	2	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Koyano F (2014), Kane LA (2014), Kane LA (2014), Shiba-Fukushima K (2014), Okatsu K (2015), Fiesel FC (2015), Ando M (2017), Klosowiak JL (2016)	8
PRKN	1	PSMD2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Um JW (2010), Sarraf SA (2013), Sarraf SA (2013)	3
PARK7	0	BCL2L1	0	pull down, pull down, affinity chromatography technology	Ren H (2011), Ren H (2011), Ren H (2011)	3
PINK1	2	TOMM22	0	affinity chromatography technology	Lazarou M (2012)	1
MCL1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Stankiewicz AR (2009)	2
KRAS	1	COPS8	2	genetic interference	Luo J (2009)	1
PSMC6	0	PSMD1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TRAF6	0	SNCA	0	affinity chromatography technology	Zucchelli S (2010)	1
PINK1	2	TGM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Min B (2015), Min B (2015), Min B (2015), Min B (2015)	4
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
PRKN	1	DNM1L	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang H (2011), Wang H (2011), Wang H (2011), Wang H (2011)	4
PINK1	2	PSMD2	2	affinity chromatography technology	Imai Y (2010)	1
PARK7	0	HSD17B10	1	affinity chromatography technology	Malty RH (2017)	1
CDC37	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Basso AD (2002), Basso AD (2002), Kim H (2014), Sun L (2012)	4
PINK1	2	UBE2M	0	affinity chromatography technology, enzymatic study	Choo YS (2012), Choo YS (2012)	2
TOMM20	0	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
FBXO7	1	IRS4	2	affinity chromatography technology	Teixeira FR (2016)	1
HSPA1A	0	BAG2	0	affinity chromatography technology	Schoenbuehler B (2016)	1
PINK1	2	BAG5	0	two hybrid, affinity chromatography technology, pull down, pull down	Wang X (2014), Wang X (2014), Wang X (2014), Wang X (2014)	4
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
UBC	7	BAG2	0	affinity chromatography technology	Matsumoto M (2005)	1
RHOT2	1	RHOT1	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Woodford MR (2016)	2
HSP90AB1	2	PSMD1	2	affinity chromatography technology	Falsone SF (2005)	1
MCL1	1	PINK1	2	affinity chromatography technology	Hollville E (2014)	1
PARK7	0	PINK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tang B (2006), Tang B (2006), Xiong H (2009), Xiong H (2009), Xiong H (2009)	5
BNIP3	2	TGM2	2	two hybrid	Wang J (2011)	1
BAG2	0	PINK1	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Che X (2013), Che X (2013), Che X (2013), Che X (2013)	4
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
HSP90AA1	7	SNCA	0	pull down	Falsone SF (2009)	1
MAP1LC3A	0	TUBB	3	affinity chromatography technology	Wang BS (2013)	1
PINK1	2	AKT1	1	affinity chromatography technology, affinity chromatography technology	Murata H (2011), Murata H (2011)	2
UBE2M	0	PRKN	1	enzymatic study	Choo YS (2012)	1
HSD17B10	1	PSMC6	0	affinity chromatography technology	Malty RH (2017)	1
MAPKAP1	0	AKT1	1	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, two hybrid, pull down	Jacinto E (2006), Murata H (2011), Facchinetti V (2008), Facchinetti V (2008), Tatebe H (2017), Tatebe H (2017)	6
PRKN	1	HTRA2	1	affinity chromatography technology	Park HM (2009)	1
PTEN	24	HSP90AB1	2	affinity chromatography technology, pull down	Maddika S (2011), Verrastro I (2015)	2
RICTOR	4	MAPKAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jacinto E (2006), Yang Q (2006), Jacinto E (2006), Pearce LR (2007), Pearce LR (2007), Gao D (2010), Gao D (2010), Oh WJ (2010), Oh WJ (2010), Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Ikenoue T (2008), Murata H (2011), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Martin J (2008), Thedieck K (2007), Hong F (2008), Facchinetti V (2008), Chen CH (2011), Glidden EJ (2012), Thedieck K (2007)	24
PINK1	2	IMMT	0	affinity chromatography technology, affinity chromatography technology	Weihofen A (2009), Weihofen A (2009)	2
TOLLIP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Li S (2011), Lee JY (2009), Yagasaki Y (2004), Neumann D (2007), Ohnuma K (2005), Ohnuma K (2005), Jensen LE (2001), Rao N (2005), Lee HJ (2012), Lei L (2016)	12
TOMM70	1	HSP90AA1	7	affinity chromatography technology, pull down	Liu XY (2010), Liu XY (2010)	2
HSP90AA1	7	TUBB	3	affinity chromatography technology	Skarra DV (2011)	1
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
PARK7	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2005), Moore DJ (2005), Olzmann JA (2007), Olzmann JA (2007), Olzmann JA (2007), Xiong H (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Chang C (2014), Chang C (2014)	11
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
PINK1	2	HSP90AB1	2	affinity chromatography technology	Weihofen A (2008)	1
PINK1	2	VIM	0	affinity chromatography technology	Murata H (2013)	1
HSPA1A	0	SNCA	0	fluorescent resonance energy transfe, pull down	Roodveldt C (2009), Roodveldt C (2009)	2
HSP90AB1	2	TUBB	3	biochemical	Wan C (2015)	1
PSMC6	0	PSMD2	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CDC37	0	TUBB	3	affinity chromatography technology	Li J (2013)	1
UBC	7	PSMC6	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MAP1LC3A	0	HSPA1A	0	affinity chromatography technology	Wang BS (2013)	1
PRKN	1	TUBA1A	13	affinity chromatography technology	Hampe C (2006)	1
UBE2M	0	NAE1	0	affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology	Ewing RM (2007), Huang DT (2007), Souphron J (2008), Huang DT (2009), Huttlin EL (2017)	5
AKT1	1	HSP90AB1	2	affinity chromatography technology	Sato S (2000)	1
BAG5	0	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kalia LV (2011), Kalia LV (2011), Kalia SK (2004), Kalia SK (2004), Kalia SK (2004), Kalia SK (2004)	6
PRKN	1	BAG5	0	affinity chromatography technology, pull down	Kalia SK (2004), Kalia SK (2004)	2
PRKN	1	BNIP3	2	imaging technique	Zhang T (2016)	1
IRS4	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Sano H (2002), Skarra DV (2011)	2
FBXO7	1	TOMM20	0	enzymatic study, affinity chromatography technology	Teixeira FR (2016), Teixeira FR (2016)	2
PINK1	2	TUBA1A	13	affinity chromatography technology	Imai Y (2010)	1
PINK1	2	HSPA1B	1	affinity chromatography technology	Murata H (2013)	1
KRAS	1	TOMM20	0	genetic interference	Luo J (2009)	1
PINK1	2	RHOT2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weihofen A (2009), Weihofen A (2009), Weihofen A (2009)	3
DNM1L	3	HSD17B10	1	affinity chromatography technology	Malty RH (2017)	1
STAT3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wei J (2012), Wei J (2012)	2
PINK1	2	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Imai Y (2010), Moriwaki Y (2008)	2
PTEN	24	PINK1	2	affinity chromatography technology	Crockett DK (2005)	1
HSD17B10	1	TRAF6	0	two hybrid	Narayan SB (2012)	1
PINK1	2	PRKDC	12	affinity chromatography technology	Imai Y (2010)	1
TRAF6	0	KRAS	1	affinity chromatography technology	Han Q (2014)	1
STAT3	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kojima H (2005), Kojima H (2005), Kojima H (2005)	3
BCL2L2	0	PRKN	1	affinity chromatography technology	Hollville E (2014)	1
PTEN	24	AKT1	1	affinity chromatography technology, fluorescent resonance energy transfe	Mistafa O (2010), Ivanov AA (2017)	2
HSP90AA1	7	PSMD1	2	affinity chromatography technology	Falsone SF (2005)	1
PRKN	1	RHOT2	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sun Y (2012), Sarraf SA (2013), Klosowiak JL (2016)	3
TOMM22	0	TOMM40	1	affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Ott M (2007), Lazarou M (2012), Havugimana PC (2012), Humphries AD (2005), Huttlin EL (2017)	5
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
PINK1	2	TOMM40	1	affinity chromatography technology, affinity chromatography technology	Lazarou M (2012), Ando M (2017)	2
PINK1	2	HSPA1A	0	affinity chromatography technology	Murata H (2013)	1
PRKN	1	SNCAIP	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, two hybrid	Chung KK (2001), Chung KK (2001), Chung KK (2001), Sriram SR (2005), Smith WW (2005), Ramsey CP (2010), Kalia SK (2004), Sato S (2006), Parelkar SS (2012), Bandopadhyay R (2005)	10
AKT1	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu QS (2011), Zhu QS (2011), Zhu QS (2011), Zhu QS (2011)	4
TUBB	3	HSPA1A	0	biochemical	Kristensen AR (2012)	1
IRAK1	1	STAT3	0	affinity chromatography technology, affinity chromatography technology	Huang Y (2004), Huang Y (2004)	2
PINK1	2	TUBB	3	affinity chromatography technology	Imai Y (2010)	1
RHOT1	0	PINK1	2	affinity chromatography technology	Liu S (2012)	1
HSD17B10	1	COPS8	2	affinity chromatography technology	Malty RH (2017)	1
TOMM20	0	SARM1	3	affinity chromatography technology	Murata H (2013)	1
PINK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2010), Weihofen A (2008), Weihofen A (2008), Moriwaki Y (2008), Moriwaki Y (2008), Taipale M (2012), Ando M (2017)	7
AKT1	1	TUBB	3	affinity chromatography technology, affinity chromatography technology	Klein JB (2005), Zhu QS (2011)	2
PINK1	2	SARM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Murata H (2013), Murata H (2013), Murata H (2013)	3
PINK1	2	BNIP3	2	affinity chromatography technology, affinity chromatography technology	Zhang T (2016), Zhang T (2016)	2
PINK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee HJ (2012), Lee HJ (2012), Lee HJ (2012)	3
BCL2L2	0	PINK1	2	affinity chromatography technology	Hollville E (2014)	1
PINK1	2	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Murata H (2011), Murata H (2011)	2
PTEN	24	TUBB	3	pull down	Verrastro I (2015)	1
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
PINK1	2	TOLLIP	3	affinity chromatography technology, affinity chromatography technology	Lee HJ (2012), Lee HJ (2012)	2
MCL1	1	HSPA1A	0	affinity chromatography technology	Boiani M (2013)	1
PRKN	1	PSMC6	0	affinity chromatography technology	Sarraf SA (2013)	1
SNCA	0	TUBB	3	affinity chromatography technology	Alim MA (2002)	1
PRKN	1	HSP90AB1	2	affinity chromatography technology	Zanon A (2013)	1
MAP1LC3A	0	SNCA	0	imaging technique	Schwarz L (2012)	1
PRKDC	12	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference	Feng J (2004), Feng J (2004), Feng J (2004), Dragoi AM (2005), Dragoi AM (2005), Dragoi AM (2005), Shen JP (2017)	7
TRAF6	0	PSMD1	2	affinity chromatography technology	Bouwmeester T (2004)	1
PGAM5	4	BCL2L1	0	affinity chromatography technology	Lo SC (2006)	1
PINK1	2	MAP1B	5	affinity chromatography technology	Imai Y (2010)	1
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
PINK1	2	IRS4	2	affinity chromatography technology	Imai Y (2010)	1
PINK1	2	TOMM70	1	affinity chromatography technology	Lazarou M (2012)	1
UBC	7	HSP90AB1	2	affinity chromatography technology	Bish RA (2007)	1
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
AKT1	1	HSPA4	3	affinity chromatography technology	Doong H (2003)	1
DNM1L	3	PSMD2	2	affinity chromatography technology	Malty RH (2017)	1
PRKN	1	TOMM22	0	affinity chromatography technology	Sarraf SA (2013)	1
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
PSMD1	2	TUBA1A	13	biochemical	Havugimana PC (2012)	1
HTRA2	1	HSD17B10	1	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
TOMM20	0	HSD17B10	1	fluorescent resonance energy transfe	Bertolin G (2015)	1
PINK1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2010), Weihofen A (2008), Weihofen A (2008), Moriwaki Y (2008), Moriwaki Y (2008), Ando M (2017)	6
IRS4	2	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
AKT1	1	BCL2L1	0	enzymatic study	Qi XJ (2006)	1
SNCA	0	UBC	7	fluorescent resonance energy transfe, affinity chromatography technology	Sharma N (2001), Nemes Z (2009)	2
PRKN	1	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Zanon A (2013)	4
RICTOR	4	AKT1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study	Sarbassov DD (2006), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Woods NT (2012), Kim EK (2011), Chen CH (2011), Garcia-Martinez JM (2009), Chen TC (2014), Pitre A (2012)	10
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
PINK1	2	RB1CC1	9	affinity chromatography technology	Murata H (2013)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
RHOT2	1	UBC	7	affinity chromatography technology	Huttlin EL (2017)	1
TOMM20	0	TOMM70	1	biochemical	Havugimana PC (2012)	1
KRAS	1	PINK1	2	genetic interference	Luo J (2009)	1
DNM1L	3	CDC37	0	affinity chromatography technology	Malty RH (2017)	1
MAP1LC3A	0	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
TOMM22	0	HSD17B10	1	fluorescent resonance energy transfe	Bertolin G (2015)	1
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
AKT1	1	IRAK1	1	affinity chromatography technology	Chen BC (2002)	1
HSPA1B	1	TGM2	2	two hybrid	Wang J (2011)	1
TOMM70	1	TRAF6	0	affinity chromatography technology	Liu XY (2010)	1
TOMM40	1	HSPA4	3	pull down	Humphries AD (2005)	1
PINK1	2	PSMC6	0	affinity chromatography technology	Imai Y (2010)	1
RICTOR	4	HSPA4	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Pearce LR (2007), Martin J (2008), Martin J (2008), Martin J (2008)	4
PINK1	2	PARL	1	affinity chromatography technology	Shi G (2011)	1
PRKN	1	VIM	0	affinity chromatography technology	Zanon A (2013)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
HSP90AB1	2	PRKDC	12	affinity chromatography technology	Falsone SF (2005)	1
STAT3	0	PINK1	2	two hybrid	Grossmann A (2015)	1
PINK1	2	MAPKAP1	0	affinity chromatography technology, affinity chromatography technology	Murata H (2011), Murata H (2011)	2
SNCA	0	BAG5	0	affinity chromatography technology, pull down	Kalia LV (2011), Kalia LV (2011)	2
BCL2L1	0	BNIP3	2	two hybrid, two hybrid, affinity chromatography technology	Ray R (2000), Ray R (2000), Ray R (2000)	3
IRAK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	4
SARM1	3	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
PINK1	2	KIF11	5	affinity chromatography technology	Imai Y (2010)	1
PARK7	0	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meulener MC (2005), Meulener MC (2005), Shendelman S (2004)	3
RICTOR	4	TUBA1A	13	affinity chromatography technology	Pearce LR (2007)	1
TOMM22	0	TOMM20	0	affinity chromatography technology, biochemical	Yano M (2000), Havugimana PC (2012)	2
CRLS1	0	PINK1	2	affinity chromatography technology, enzymatic study, pull down	Chen BB (2014), Chen BB (2014), Chen BB (2014)	3
APPL2	4	PINK1	2	two hybrid	Grossmann A (2015)	1
PINK1	2	SNCA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Um JW (2009), Um JW (2009), Szargel R (2016), Szargel R (2016)	4
TOMM40	1	HSP90AA1	7	pull down	Humphries AD (2005)	1
HTRA2	1	PINK1	2	affinity chromatography technology, affinity chromatography technology	Plun-Favreau H (2007), Plun-Favreau H (2007)	2
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
PSMD1	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
PINK1	2	DNM1L	3	fluorescent resonance energy transfe	Bertolin G (2015)	1
IRAK1	1	IMMT	0	affinity chromatography technology	So J (2015)	1
IRAK1	1	RHOT1	0	affinity chromatography technology	Li S (2011)	1
MARK2	6	PINK1	2	two hybrid, affinity chromatography technology, enzymatic study	Matenia D (2012), Matenia D (2012), Matenia D (2012)	3
IRAK1	1	TOMM70	1	affinity chromatography technology	Li S (2011)	1
FBXO7	1	UBE2M	0	enzymatic study	Teixeira FR (2016)	1
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
PRKN	1	PSMD1	2	affinity chromatography technology	Sarraf SA (2013)	1
CDC37	0	HSPA1A	0	affinity chromatography technology	Li J (2013)	1
HTRA2	1	VIM	0	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
HTRA2	1	TUBA1A	13	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
CDC37	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
MAP3K7	2	CDC37	0	affinity chromatography technology	Liu XY (2008)	1
IRAK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	De Nardo D (2005), De Nardo D (2005)	2
HSP90AA1	7	BAG2	0	affinity chromatography technology	Gano JJ (2010)	1
HTRA2	1	TUBB	3	unspecified method, enzymatic study	Vande Walle L (2007), Vande Walle L (2007)	2
PTEN	24	HSP90AA1	7	affinity chromatography technology, genetic interference	Maddika S (2011), Shen JP (2017)	2
HSPA4	3	TUBB	3	biochemical	Wan C (2015)	1
PRKN	1	TOMM40	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Bertolin G (2013), Bertolin G (2013)	2
RB1CC1	9	UBC	7	pull down	Choi JD (2012)	1
BCL2L1	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hollville E (2014), Hollville E (2014), Gong Y (2017), Gong Y (2017), Gong Y (2017)	5
HSP90AB1	2	HSPA1A	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Falsone SF (2005)	2
PARK7	0	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Das F (2011), Das F (2011), Kim YC (2009), Kim YC (2009)	4
PINK1	2	NAE1	0	affinity chromatography technology	Choo YS (2012)	1
PTEN	24	HSPA1A	0	affinity chromatography technology	Maddika S (2011)	1
BAG2	0	HSPA4	3	pull down	Dai Q (2005)	1
MAP1LC3A	0	PINK1	2	affinity chromatography technology, affinity chromatography technology	Kawajiri S (2010), Kawajiri S (2010)	2
PRKN	1	BAG2	0	affinity chromatography technology	Zanon A (2013)	1
PTEN	24	TUBA1A	13	genetic interference	Vizeacoumar FJ (2013)	1
TOMM20	0	PINK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lazarou M (2012), Lazarou M (2012), Murata H (2013)	3
COPS8	2	VIM	0	biochemical	Kristensen AR (2012)	1
HSD17B10	1	TOMM40	1	biochemical, fluorescent resonance energy transfe	Wan C (2015), Bertolin G (2015)	2
KRAS	1	UBE2M	0	genetic interference	Luo J (2009)	1
TUBA1A	13	UBC	7	affinity chromatography technology	Seiberlich V (2012)	1
TOMM40	1	IMMT	0	affinity chromatography technology	Hein MY (2015)	1