PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UPF3A	2	AGGF1	2	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	APP	1	pull down	Olah J (2011)	1
UPF3A	2	HTT	14	affinity chromatography technology	Suter B (2013)	1
UPF1	8	EXOSC10	1	affinity chromatography technology	Lejeune F (2003)	1
NXF1	0	AGGF1	2	affinity chromatography technology	Castello A (2012)	1
FGFR1OP	0	UPF3A	2	affinity chromatography technology	Hein MY (2015)	1
RNF41	2	UPF3A	2	affinity chromatography technology	Hein MY (2015)	1
SRRM1	2	FUS	0	affinity chromatography technology	Meissner M (2003)	1
UPF2	2	EXOSC2	2	affinity chromatography technology	Lejeune F (2003)	1
UPF3A	2	CASC3	0	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhou F (2012), Zhou F (2012), Olah J (2011)	3
RNPS1	1	SRRM1	2	affinity chromatography technology	Ewing RM (2007)	1
UPF3B	6	UPF2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology	Lehner B (2004), Lejeune F (2003), Lykke-Andersen J (2002), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Kashima I (2006), Lehner B (2004), Wan C (2015), Hein MY (2015)	9
XPO1	8	RNPS1	1	affinity chromatography technology	Kirli K (2015)	1
UPF1	8	UPF3B	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Schell T (2003), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Yamashita A (2009), Franks TM (2010), Izumi N (2010), Li S (2014), Hein MY (2015)	9
RNPS1	1	UPF1	8	affinity chromatography technology	Lykke-Andersen J (2001)	1
RBM8A	2	HBB	0	affinity chromatography technology	Franks TM (2010)	1
SMG1	7	UPF3B	6	affinity chromatography technology, affinity chromatography technology	Ivanov PV (2008), Kashima I (2006)	2
NXF1	0	UPF3B	6	affinity chromatography technology	Lykke-Andersen J (2001)	1
UPF3A	2	DCP2	0	affinity chromatography technology	Lejeune F (2003)	1
XPO1	8	UPF1	8	affinity chromatography technology	Kirli K (2015)	1
UPF2	2	DCP2	0	affinity chromatography technology, two hybrid	Lejeune F (2003), Lehner B (2004)	2
TOPORS	6	UPF3A	2	affinity chromatography technology	Pungaliya P (2007)	1
UPF3A	2	UPF2	2	affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Lykke-Andersen J (2000)	2
UPF2	2	PARN	2	affinity chromatography technology	Lejeune F (2003)	1
XPO1	8	UPF3A	2	affinity chromatography technology	Kirli K (2015)	1
UPF3A	2	IFITM2	2	two hybrid	Lehner B (2004)	1
UPF3A	2	XRN1	4	affinity chromatography technology	Lejeune F (2003)	1
UPF3A	2	GSK3B	1	two hybrid	Lehner B (2004)	1
UPF1	8	UPF3A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schell T (2003), Yamashita A (2001), Lykke-Andersen J (2000)	3
UPF3A	2	HBB	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Lykke-Andersen J (2000), Franks TM (2010), Huttlin EL (2017)	3
XRN1	4	WAPL	1	two hybrid	Lehner B (2004)	1
UPF3A	2	EXOSC10	1	affinity chromatography technology	Lejeune F (2003)	1
UPF3A	2	EXOSC2	2	affinity chromatography technology	Lejeune F (2003)	1
UPF3A	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FUS	0	UPF1	8	genetic interference	Ju S (2011)	1
UPF3A	2	EXOSC4	1	affinity chromatography technology	Lejeune F (2003)	1
ALB	1	APOA1	0	affinity chromatography technology	Zhou M (2004)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
UPF2	2	XRN1	4	affinity chromatography technology	Lejeune F (2003)	1
UPF3A	2	PARN	2	affinity chromatography technology	Lejeune F (2003)	1
UPF1	8	HBB	0	affinity chromatography technology	Franks TM (2010)	1
RBM8A	2	UPF3A	2	pull down, affinity chromatography technology	Kim VN (2001), Kim VN (2001)	2
FUS	0	ALB	1	affinity chromatography technology	Wang T (2014)	1
RNPS1	1	UPF3B	6	affinity chromatography technology, biochemical	Lykke-Andersen J (2001), Havugimana PC (2012)	2
SRRM1	2	RBM8A	2	affinity chromatography technology	McCracken S (2005)	1
UPF3A	2	SMG1	7	affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Kashima I (2006)	2
HBD	0	APP	1	pull down	Olah J (2011)	1
XRN1	4	EXOSC10	1	two hybrid	Lehner B (2004)	1
SRRM1	2	UPF3A	2	affinity chromatography technology	Lykke-Andersen J (2001)	1
UPF3A	2	SERPINA1	1	affinity chromatography technology	Huttlin EL (2017)	1
UPF1	8	EXOSC2	2	affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Isken O (2008)	2
SRRM1	2	WAPL	1	affinity chromatography technology	McCracken S (2005)	1
UPF1	8	XRN1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Franks TM (2010), Isken O (2008)	3
NXF1	0	EXOSC2	2	affinity chromatography technology	Castello A (2012)	1
UPF3A	2	CA1	0	affinity chromatography technology	Huttlin EL (2017)	1
PHF8	6	UPF3A	2	affinity chromatography technology	Hein MY (2015)	1
UPF3B	6	CASC3	0	pull down, affinity chromatography technology	Barbosa I (2012), Hein MY (2015)	2
UPF2	2	HBB	0	affinity chromatography technology	Franks TM (2010)	1
UPF3A	2	UPF3B	6	affinity chromatography technology	Lejeune F (2003)	1
UPF1	8	RBM8A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
UPF2	2	EXOSC10	1	affinity chromatography technology, two hybrid	Lejeune F (2003), Lehner B (2004)	2
UPF2	2	EXOSC4	1	affinity chromatography technology	Lejeune F (2003)	1
UPF3A	2	APOA1	0	affinity chromatography technology	Huttlin EL (2017)	1
UPF1	8	EXOSC4	1	affinity chromatography technology	Lejeune F (2003)	1
SMG1	7	UPF1	8	enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Yamashita A (2001), Yamashita A (2001), Yamashita A (2009), Yamashita A (2009), Ivanov PV (2008), Isken O (2008), Kashima I (2006), Kashima I (2006), Kashima I (2006), Izumi N (2010)	11
RBM8A	2	RNPS1	1	pull down, biochemical	Kataoka N (2001), Havugimana PC (2012)	2
NXF1	0	CASC3	0	affinity chromatography technology, affinity chromatography technology	Castello A (2012), Huttlin EL (2017)	2
UPF1	8	UPF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Schell T (2003), Schell T (2003), Mendell JT (2000), Yamashita A (2001), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Azzalin CM (2006), Azzalin CM (2006), Kaygun H (2005), Yamashita A (2009), Franks TM (2010), Ivanov PV (2008), Kashima I (2006), Izumi N (2010), Li S (2014)	16
UPF3A	2	LONP1	9	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	HBA2	0	affinity chromatography technology	Zhou M (2004)	1
RBM8A	2	UPF3B	6	affinity chromatography technology, affinity chromatography technology, pull down	Kashima I (2006), Izumi N (2010), Barbosa I (2012)	3
UPF3A	2	HBA2	0	affinity chromatography technology	Huttlin EL (2017)	1
RBM8A	2	APP	1	pull down	Olah J (2011)	1
WAPL	1	UPF3A	2	affinity chromatography technology	Hein MY (2015)	1
RNPS1	1	UPF3A	2	affinity chromatography technology, affinity chromatography technology	Lykke-Andersen J (2001), Huttlin EL (2017)	2
RBM8A	2	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Kashima I (2006), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	UPF3B	6	affinity chromatography technology	Kirli K (2015)	1
NXF1	0	UPF3A	2	affinity chromatography technology	Lykke-Andersen J (2001)	1
UPF3A	2	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	FGFR1OP	0	affinity chromatography technology	Kirli K (2015)	1
UPF2	2	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Ivanov PV (2008), Kashima I (2006), Kashima I (2006), Kashima I (2006), Izumi N (2010)	6
FUS	0	UPF2	2	genetic interference	Ju S (2011)	1
UPF3A	2	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
UPF1	8	PARN	2	affinity chromatography technology	Lejeune F (2003)	1
RNPS1	1	UPF2	2	affinity chromatography technology, two hybrid	Lykke-Andersen J (2001), Lehner B (2004)	2
RNF41	2	APP	1	pull down	Olah J (2011)	1
EXOSC2	2	EXOSC10	1	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
UPF3B	6	HBB	0	unspecified method	Lykke-Andersen J (2000)	1
PHF8	6	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NXF1	0	EXOSC10	1	affinity chromatography technology	Castello A (2012)	1
RNPS1	1	NXF1	0	affinity chromatography technology	Lykke-Andersen J (2001)	1
APOA1	0	APP	1	pull down	Olah J (2011)	1
RBM8A	2	UPF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Kashima I (2006), Kashima I (2006), Izumi N (2010), Hein MY (2015)	5
XPO1	8	UPF2	2	affinity chromatography technology	Kirli K (2015)	1
UPF1	8	DCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Lykke-Andersen J (2002), Lykke-Andersen J (2002), Fenger-Gron M (2005)	4
EXOSC2	2	EXOSC4	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raijmakers R (2002), Raijmakers R (2002), Raijmakers R (2002), Tomecki R (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	9
EXOSC4	1	EXOSC10	1	affinity chromatography technology, biochemical, two hybrid, two hybrid, biochemical, affinity chromatography technology	Tomecki R (2010), Havugimana PC (2012), Lehner B (2004), Lehner B (2004), Wan C (2015), Hein MY (2015)	6
RBM8A	2	CASC3	0	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	XRN1	4	affinity chromatography technology	Kirli K (2015)	1
FUS	0	UPF3A	2	genetic interference	Ju S (2011)	1
UPF3A	2	HBD	0	affinity chromatography technology	Huttlin EL (2017)	1
RBM8A	2	NXF1	0	pull down	Kataoka N (2001)	1
XPO1	8	CASC3	0	affinity chromatography technology	Kirli K (2015)	1