PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DVL2	5	CCDC33	3	two hybrid	Rual JF (2005)	1
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
PAXIP1	1	PIAS2	2	two hybrid	Woods NT (2012)	1
KIF9	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
BAZ2B	15	ZBTB8A	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
PIAS2	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
PNMA5	0	ZBTB8A	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP70	1	ZBTB49	5	two hybrid	Rolland T (2014)	1
KAT7	3	ZBTB8A	0	two hybrid	Rual JF (2005)	1
PAXIP1	1	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ZBTB24	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZBTB48	3	ZBTB8A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MCM10	2	CEP70	1	two hybrid	Rual JF (2005)	1
EP300	36	ZBTB8A	0	affinity chromatography technology, affinity chromatography technology, pull down	Kim MK (2013), Kim MK (2013), Kim MK (2013)	3
ZBTB49	5	EP300	36	affinity chromatography technology, pull down, pull down	Jeon BN (2014), Jeon BN (2014), Jeon BN (2014)	3
ZCCHC10	0	CEP70	1	two hybrid	Rolland T (2014)	1
ZBTB8A	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology	Kim MK (2013), Kim MK (2013), Kim MK (2013)	3
ZCCHC10	0	LNX1	7	two hybrid	Rolland T (2014)	1
ZBTB8A	0	ZBTB8A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZBTB48	3	ZBTB24	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM41	6	ZNF417	2	two hybrid	Rolland T (2014)	1
80022	0	ZBTB8A	0	two hybrid	Rual JF (2005)	1
KIFC3	3	TRIM41	6	two hybrid	Rolland T (2014)	1
ZNF250	2	TRIM41	6	two hybrid	Rolland T (2014)	1
FXR2	2	CCDC33	3	two hybrid	Rual JF (2005)	1
YES1	1	FXR2	2	two hybrid	Rolland T (2014)	1
AP1M1	3	ZBTB8A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KIFC3	3	CCDC33	3	two hybrid	Rolland T (2014)	1
LNX1	7	AP2M1	5	affinity chromatography technology	Lenihan JA (2017)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
ZNF138	1	TRIM41	6	two hybrid	Rolland T (2014)	1
SDCBP	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
GPATCH2L	1	ZNF408	0	two hybrid	Rolland T (2014)	1
KIFC3	3	MFAP1	3	two hybrid	Rolland T (2014)	1
DVL2	5	ZGPAT	3	two hybrid	Yu H (2011)	1
ZNF587	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
UBE2I	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
GPATCH2L	1	CEP70	1	two hybrid	Rolland T (2014)	1
SDCBP	0	ZCCHC10	0	two hybrid	Rolland T (2014)	1
FXR2	2	BAZ2B	15	two hybrid	Rolland T (2014)	1
SDCBP	0	EIF1AD	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	PRKAA2	1	affinity chromatography technology	Fei T (2017)	1
KIF5B	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
TP53	0	PIAS2	2	pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique	Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014)	6
AP2M1	5	ZBTB8A	0	two hybrid	Rual JF (2005)	1
AP2M1	5	DVL2	5	two hybrid	Rual JF (2005)	1
FXR2	2	ZBTB8A	0	two hybrid	Rual JF (2005)	1
LMO3	0	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ARMCX1	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
WDYHV1	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZBTB49	5	ZBTB8A	0	two hybrid	Rolland T (2014)	1
MCM10	2	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ZBTB49	5	KAT5	1	affinity chromatography technology	Jeon BN (2014)	1
RPL9	1	ZBTB8A	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CEP70	1	ZGPAT	3	two hybrid	Rolland T (2014)	1
KAT7	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Iizuka M (2008), Iizuka M (2008), Iizuka M (2008)	3
KIFC3	3	ZGPAT	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
BYSL	3	CCDC33	3	two hybrid	Rolland T (2014)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
FXR2	2	SYT6	1	two hybrid	Rolland T (2014)	1
PRKAA2	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZBTB24	1	TRIM41	6	two hybrid	Rolland T (2014)	1
MFAP1	3	ZBTB8A	0	two hybrid	Rolland T (2014)	1
FAM161A	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
LMO3	0	CCDC33	3	two hybrid	Rolland T (2014)	1
80022	0	PNMA5	0	two hybrid	Rolland T (2014)	1
SYT6	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZCCHC10	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
CDKL3	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZNF138	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
GPATCH2L	1	CCDC33	3	two hybrid	Rolland T (2014)	1
DVL2	5	YES1	1	two hybrid	Yu H (2011)	1
ZNF250	2	ZBTB8A	0	two hybrid	Rual JF (2005)	1
KIFC3	3	PRKAA2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KIFC3	3	ZBTB8A	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	PRPF3	3	affinity chromatography technology	Fei T (2017)	1
AEN	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
TRIM41	6	ZBTB8A	0	two hybrid	Rual JF (2005)	1
CEP70	1	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ZGPAT	3	ZBTB8A	0	two hybrid	Rolland T (2014)	1
DVL2	5	PRPF3	3	two hybrid	Rual JF (2005)	1
PAXIP1	1	EP300	36	pull down	Hoffmeister A (2002)	1
LNX1	7	ZBTB8A	0	two hybrid	Rual JF (2005)	1
DVL2	5	ZBTB48	3	two hybrid	Yu H (2011)	1
DDX6	0	CEP70	1	two hybrid	Rolland T (2014)	1
MFAP1	3	CEP70	1	two hybrid	Rolland T (2014)	1
PRPF3	3	ZGPAT	3	affinity chromatography technology	Huttlin EL (2017)	1
AEN	0	TRIM41	6	two hybrid	Rolland T (2014)	1
AP2M1	5	FXR2	2	two hybrid	Rual JF (2005)	1
RAD23A	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Brignone C (2004), Hsieh HC (2005)	2
DVL2	5	ZNF250	2	two hybrid	Rual JF (2005)	1
ZBTB8A	0	PRPF3	3	two hybrid	Yu H (2011)	1
RAD23A	1	PSMC1	2	affinity chromatography technology, biochemical	Scanlon TC (2009), Wan C (2015)	2
PRPF3	3	MFAP1	3	two hybrid, two hybrid, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Hegele A (2012)	3
HNRNPL	3	ZBTB8A	0	affinity chromatography technology	Fei T (2017)	1
ZCCHC10	0	TP53	0	two hybrid	Stelzl U (2005)	1
DDX6	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
DVL2	5	ZBTB8A	0	two hybrid	Rual JF (2005)	1
YES1	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZNF417	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZNF587	0	TRIM41	6	two hybrid	Rolland T (2014)	1
CCDC33	3	ZGPAT	3	two hybrid	Rolland T (2014)	1
ZBTB24	1	CEP70	1	two hybrid	Rolland T (2014)	1
ZNF408	0	ZBTB8A	0	two hybrid	Rual JF (2005)	1
MFAP1	3	FXR2	2	two hybrid	Rolland T (2014)	1
CEP70	1	ZNF417	2	two hybrid	Rolland T (2014)	1
DVL2	5	TP53	0	two hybrid, two hybrid	Rual JF (2005), Lim J (2006)	2
KAT5	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng Z (2008), Cheng Z (2008), Cheng Z (2008)	3
KAT5	1	ZBTB8A	0	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
UBE2I	0	TRIM41	6	two hybrid	Markson G (2009)	1
CCDC33	3	ZBTB8A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
EP300	36	KAT5	1	affinity chromatography technology, affinity chromatography technology	Col E (2005), Col E (2005)	2
BYSL	3	CEP70	1	two hybrid	Rolland T (2014)	1
DDX6	0	PNMA5	0	two hybrid	Rolland T (2014)	1
TNIP3	3	ZBTB8A	0	two hybrid	Rolland T (2014)	1
PSMC1	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
CCDC33	3	FAM161A	2	two hybrid	Rolland T (2014)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
ZBTB48	3	GPATCH2L	1	two hybrid	Rolland T (2014)	1
WDYHV1	0	PNMA5	0	two hybrid	Rolland T (2014)	1
ZBTB48	3	TRIM41	6	two hybrid	Yu H (2011)	1
PRKAA2	1	UBE2I	0	two hybrid	Moreno D (2009)	1
AP1M1	3	FXR2	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
GPATCH2L	1	TRIM41	6	two hybrid	Rolland T (2014)	1
FXR2	2	ZMAT2	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	ZNF587	0	affinity chromatography technology	Fei T (2017)	1
CEP70	1	ZNF587	0	two hybrid	Rolland T (2014)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
ACOT12	2	ZBTB8A	0	affinity chromatography technology	Huttlin EL (2017)	1
BYSL	3	ZBTB8A	0	two hybrid	Rolland T (2014)	1
GPATCH2L	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
RAD23A	1	ZBTB8A	0	two hybrid	Rolland T (2014)	1
ZNF276	1	ZBTB8A	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
KAT7	3	CEP70	1	two hybrid	Rual JF (2005)	1
BYSL	3	FXR2	2	two hybrid	Rolland T (2014)	1
FXR2	2	CDKL3	1	two hybrid	Rolland T (2014)	1
AP2M1	5	DDX6	0	affinity chromatography technology	Brehme M (2009)	1
AP1M1	3	PNMA5	0	two hybrid	Rolland T (2014)	1
ZNF408	0	TRIM41	6	affinity chromatography technology	Huttlin EL (2017)	1
ZNF408	0	CEP70	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
CEP70	1	FAM161A	2	two hybrid	Rolland T (2014)	1
DVL2	5	AP1M1	3	two hybrid	Rual JF (2005)	1
ZNF587	0	ZNF417	2	two hybrid	Rolland T (2014)	1
PRPF3	3	ZCCHC10	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
ZBTB48	3	EP300	36	affinity chromatography technology, pull down	Yoon JH (2014), Yoon JH (2014)	2
ZMAT2	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1
EIF1AD	0	ZBTB8A	0	two hybrid	Rolland T (2014)	1