PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP15	4	BMPR1B	3	affinity chromatography technology	Herhaus L (2014)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
USP15	4	BMPR1A	5	affinity chromatography technology, imaging technique, enzymatic study	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
BMPR1B	3	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
GDF5	0	BMPR2	1	pull down	Erlacher L (1998)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
PEG10	2	BMPR1B	3	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
BMPR1B	3	OTUB1	0	enzymatic study	Herhaus L (2015)	1
BMPR1B	3	TRAF6	0	affinity chromatography technology	Sorrentino A (2008)	1
BMPR2	1	XIAP	0	affinity chromatography technology	Liu Z (2009)	1
BMPR1A	5	BMP2	2	x-ray crystallography, pull down, pull down, pull down	Nickel J (2001), Kirsch T (2000), Kirsch T (2000), Gilboa L (2000)	4
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
BMPR1B	3	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Itoh F (2001), Hata A (1998)	2
HNRNPL	3	SMURF1	4	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	TPRA1	4	affinity chromatography technology	Fei T (2017)	1
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
BMPR1B	3	BMPR1B	3	affinity chromatography technology	Gilboa L (2000)	1
BMPR1B	3	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
BMPR2	1	BMP4	0	affinity chromatography technology, pull down	Rosenzweig BL (1995), Rudarakanchana N (2002)	2
RGMB	1	BMP4	0	pull down	Samad TA (2005)	1
TPRA1	4	BMPR1B	3	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D1	1	OTUB1	0	two hybrid	Vinayagam A (2011)	1
HNRNPL	3	USP15	4	affinity chromatography technology	Fei T (2017)	1
RGMB	1	BMP2	2	pull down	Samad TA (2005)	1
BMPR2	1	BMPR1B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
SMAD6	9	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
TPRA1	4	APP	1	pull down	Olah J (2011)	1
BMPR1A	5	BMPR1B	3	affinity chromatography technology, imaging technique	Gilboa L (2000), Gilboa L (2000)	2
HNRNPL	3	BMPR2	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	EVA1C	0	affinity chromatography technology	Fei T (2017)	1
PEG10	2	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
EVA1C	0	BMPR1B	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BMPR1B	3	XIAP	0	affinity chromatography technology	Liu Z (2009)	1
HNRNPL	3	XIAP	0	affinity chromatography technology	Fei T (2017)	1
GDF6	1	BMPR2	1	pull down	Erlacher L (1998)	1
BMP7	3	BMPR2	1	affinity chromatography technology, affinity chromatography technology	Liu F (1995), Rosenzweig BL (1995)	2
BMP7	3	BMPR1A	5	pull down	ten Dijke P (1994)	1
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1B	3	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
BMPR1B	3	APP	1	pull down	Olah J (2011)	1
GDF6	1	BMPR1A	5	pull down	Erlacher L (1998)	1
BMP4	0	BMPR1B	3	pull down	ten Dijke P (1994)	1
BMPR1A	5	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
SMURF1	4	APP	1	pull down	Olah J (2011)	1
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
HNRNPL	3	TSC22D1	1	affinity chromatography technology	Fei T (2017)	1
BMP7	3	BMPR1B	3	pull down	ten Dijke P (1994)	1
BMPR1A	5	OTUB1	0	enzymatic study	Herhaus L (2015)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
BMP2	2	BMPR2	1	affinity chromatography technology, pull down, pull down	Liu F (1995), Kirsch T (2000), Gilboa L (2000)	3
SNX6	1	BMPR1B	3	affinity chromatography technology	Parks WT (2001)	1
BMPR2	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
GDF5	0	BMPR1A	5	pull down	Erlacher L (1998)	1
RGMB	1	BMPR1B	3	affinity chromatography technology	Samad TA (2005)	1
RGMB	1	BMPR1A	5	affinity chromatography technology	Samad TA (2005)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
HNRNPL	3	BMPR1B	3	affinity chromatography technology	Fei T (2017)	1
BMPR1B	3	BAMBI	3	pull down	Yan X (2009)	1
SMAD6	9	BAMBI	3	affinity chromatography technology	Yan X (2009)	1
BMPR1A	5	BAMBI	3	pull down	Yan X (2009)	1
BMP4	0	BMPR1A	5	pull down	ten Dijke P (1994)	1
BMP2	2	BMPR1B	3	pull down	Gilboa L (2000)	1
GDF6	1	BMPR1B	3	pull down	Erlacher L (1998)	1
GDF5	0	BMPR1B	3	pull down	Erlacher L (1998)	1