PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
PML	7	DAXX	5	two hybrid, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Ishov AM (1999), Li H (2000), Li H (2000), Li H (2000), Lehembre F (2001), Zhong S (2000), Cuchet-Lourenco D (2011), Chu Y (2011), Meinecke I (2007), Jang MS (2002), Chang CC (2011), Wethkamp N (2011), Ferguson BJ (2007), Delbarre E (2013), Delbarre E (2013), Sahin U (2014), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Torii S (1999)	21
UBA2	0	SAE1	0	two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Gong L (1999), Desterro JM (1999), Okuma T (1999), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
NXF1	0	PGD	2	affinity chromatography technology	Castello A (2012)	1
STIP1	1	SUMO3	0	biochemical	Wan C (2015)	1
ENO2	1	ARHGDIA	3	biochemical	Wan C (2015)	1
USP25	0	UBC	7	enzymatic study, pull down, enzymatic study, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, pull down	Faesen AC (2011), Nathan JA (2013), Meulmeester E (2008), Meulmeester E (2008), Zhang X (2017), Yang Y (2017), Wrigley JD (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kwasna D (2018)	12
SMN1	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
EWSR1	2	RNF168	0	biochemical	Havugimana PC (2012)	1
RNF168	0	SUMO3	0	affinity chromatography technology	Shire K (2016)	1
UCHL3	1	ARHGDIA	3	biochemical	Wan C (2015)	1
ENO1	3	UCHL3	1	biochemical	Wan C (2015)	1
DRAP1	2	SUMO3	0	biochemical	Kristensen AR (2012)	1
SENP2	3	SUMO3	0	enzymatic study, two hybrid, enzymatic study, enzymatic study	Zhang H (2002), Rolland T (2014), Zhang H (2002), Zhao Y (2015)	4
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
STIP1	1	ENO2	1	biochemical	Wan C (2015)	1
SUMO3	0	PIAS1	4	pull down	Hecker CM (2006)	1
EWSR1	2	RAD23B	1	bioid	Elzi DJ (2014)	1
SUMO3	0	PLPBP	4	biochemical	Wan C (2015)	1
SMN1	0	EWSR1	2	affinity chromatography technology	Fuller HR (2010)	1
TDG	0	SUMO3	0	pull down, two hybrid	Hardeland U (2002), Hardeland U (2002)	2
SUMO3	0	UBA2	0	affinity chromatography technology	Li T (2006)	1
TAGLN2	0	ENO1	3	biochemical	Wan C (2015)	1
UBC	7	SUMO3	0	affinity chromatography technology	Sahin U (2014)	1
SUMO3	0	ISYNA1	0	biochemical	Wan C (2015)	1
EWSR1	2	SEC23A	3	affinity chromatography technology	Elzi DJ (2014)	1
SENP5	1	SUMO3	0	enzymatic study, enzymatic study	Gong L (2006), Gong L (2006)	2
HIPK2	0	SP100	4	affinity chromatography technology	Moeller A (2003)	1
PML	7	TDG	0	affinity chromatography technology, pull down, imaging technique	Takahashi H (2005), Takahashi H (2005), Mohan RD (2007)	3
NXF1	0	TAGLN2	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	SP100	4	affinity chromatography technology	Castello A (2012)	1
DAXX	5	SUMO3	0	pull down	Chang CC (2011)	1
SUMO3	0	RNF111	2	pull down	Erker Y (2013)	1
TAGLN3	2	ENO1	3	biochemical	Wan C (2015)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
NXF1	0	SUMO3	0	affinity chromatography technology	Castello A (2012)	1
UCHL3	1	MAPRE1	0	biochemical	Wan C (2015)	1
EWSR1	2	SAE1	0	bioid	Elzi DJ (2014)	1
EWSR1	2	MAPRE1	0	bioid	Elzi DJ (2014)	1
TAGLN2	0	ENO2	1	biochemical	Wan C (2015)	1
PIAS1	4	PML	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	3
UBE2I	0	RNF111	2	two hybrid, two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010), Rolland T (2014)	3
MOV10	6	PFKM	4	affinity chromatography technology	Castello A (2012)	1
UBE2I	0	USP25	0	enzymatic study, pull down	Meulmeester E (2008), Meulmeester E (2008)	2
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
MOV10	6	TK1	0	affinity chromatography technology	Castello A (2012)	1
DAXX	5	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
UBE2I	0	SLX4	6	affinity chromatography technology, pull down	Guervilly JH (2015), Guervilly JH (2015)	2
SENP1	0	USP25	0	enzymatic study	Meulmeester E (2008)	1
TK1	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
FKBP2	0	ENO2	1	biochemical	Wan C (2015)	1
UBC	7	UBA2	0	pull down	Gong L (1999)	1
TTR	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
ENO1	3	SUMO3	0	affinity chromatography technology	Castello A (2012)	1
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
TAGLN2	0	UCHL3	1	biochemical	Wan C (2015)	1
HIPK2	0	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofmann TG (2003), Hofmann TG (2003), McDonough H (2009), Kumar N (2013)	4
NXF1	0	TDG	0	affinity chromatography technology	Castello A (2012)	1
RAD23B	1	SUMO3	0	biochemical	Wan C (2015)	1
RAD23A	1	RAD23B	1	biochemical, affinity chromatography technology	van der Spek PJ (1996), Hsieh HC (2005)	2
MOV10	6	USPL1	5	affinity chromatography technology	Castello A (2012)	1
MTAP	3	TAGLN2	0	biochemical	Wan C (2015)	1
SUMO3	0	SEC23B	0	biochemical	Wan C (2015)	1
RNF111	2	PML	7	affinity chromatography technology, two hybrid	Erker Y (2013), Woodsmith J (2012)	2
SUMO3	0	PIAS3	2	pull down	Hecker CM (2006)	1
MOV10	6	PGD	2	affinity chromatography technology	Castello A (2012)	1
SUMO3	0	RNF8	2	pull down, affinity chromatography technology, imaging technique	Liang L (2017), Liang L (2017), Liang L (2017)	3
UBE2I	0	TDG	0	enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Mohan RD (2007), Coey CT (2014)	3
SUMO3	0	USP25	0	pull down, pull down	Meulmeester E (2008), Meulmeester E (2008)	2
UBE3A	4	UFD1	1	biochemical	Havugimana PC (2012)	1
EWSR1	2	CHAF1A	1	bioid	Elzi DJ (2014)	1
PML	7	SP100	4	imaging technique, imaging technique, imaging technique, imaging technique, two hybrid, imaging technique	Cuchet-Lourenco D (2011), Cuchet-Lourenco D (2011), Cuchet D (2011), Negorev D (2001), Sternsdorf T (1997), Sahin U (2014)	6
DYNLT1	3	SUMO3	0	biochemical	Wan C (2015)	1
UBE2I	0	UBA2	0	affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Knipscheer P (2008), Tatham MH (2003), Tatham MH (2003), Huang DT (2009), Gilbreth RN (2011), Okuma T (1999), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
NXF1	0	ECHS1	2	affinity chromatography technology	Castello A (2012)	1
SUMO3	0	VIM	0	two hybrid	Stelzl U (2005)	1
SLX4	6	SUMO3	0	pull down, affinity chromatography technology	Guervilly JH (2015), Guervilly JH (2015)	2
MTAP	3	TAGLN3	2	biochemical	Wan C (2015)	1
UCHL3	1	PGD	2	biochemical	Wan C (2015)	1
DYNLT1	3	VIM	0	affinity chromatography technology	Boldt K (2016)	1
FKBP2	0	TAGLN2	0	biochemical	Wan C (2015)	1
ANXA7	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
SUMO3	0	UCHL3	1	biochemical	Wan C (2015)	1
SUMO3	0	TDP2	2	pull down	Hecker CM (2006)	1
SUMO3	0	SP100	4	pull down	Hecker CM (2006)	1
UPF2	2	ENO1	3	two hybrid	Lehner B (2004)	1
NXF1	0	SP100	4	affinity chromatography technology	Castello A (2012)	1
SENP1	0	PML	7	enzymatic study	Galisson F (2011)	1
MOV10	6	SUMO3	0	affinity chromatography technology	Castello A (2012)	1
SUMO3	0	PIAS2	2	pull down, unspecified method	Hecker CM (2006), Banani SF (2016)	2
SUMO3	0	HIPK2	0	pull down	de la Vega L (2011)	1
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
ENO2	1	SUMO3	0	biochemical	Wan C (2015)	1
ISYNA1	0	ARHGDIA	3	biochemical	Wan C (2015)	1
EWSR1	2	SUMO3	0	affinity chromatography technology	Elzi DJ (2014)	1
SEC23A	3	SUMO3	0	biochemical	Wan C (2015)	1
UBE2I	0	SP100	4	enzymatic study, pull down, two hybrid, enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Knipscheer P (2008), Bandyopadhyay S (2010), Pelisch F (2010), Meulmeester E (2008), Knipscheer P (2007)	6
RAD23B	1	VIM	0	affinity chromatography technology, affinity chromatography technology	Chen L (2006), Chen L (2006)	2
UBE2I	0	SAE1	0	affinity chromatography technology, enzymatic study, pull down, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Tatham MH (2003), Huang DT (2009), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
ENO2	1	ENO1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SAE1	0	SUMO3	0	affinity chromatography technology, biochemical	Ewing RM (2007), Wan C (2015)	2
SEC23A	3	SEC23B	0	biochemical	Wan C (2015)	1
SLX4	6	UBC	7	pull down	Lachaud C (2014)	1
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
HIPK2	0	PML	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	de la Vega L (2011), Renner F (2010), Sung KS (2011), Sung KS (2011), Gresko E (2009), Gresko E (2009), Gresko E (2009)	7
UBE3A	4	PML	7	enzymatic study, affinity chromatography technology	Louria-Hayon I (2009), Louria-Hayon I (2009)	2
SENP1	0	HIPK2	0	enzymatic study	Kim YH (2005)	1
SUMO3	0	ALDOB	2	biochemical	Wan C (2015)	1
FKBP2	0	ENO1	3	biochemical	Wan C (2015)	1
TAGLN3	2	ENO2	1	biochemical	Wan C (2015)	1
UBE2I	0	NXF1	0	affinity chromatography technology	Hein MY (2015)	1
ISYNA1	0	UCHL3	1	biochemical	Wan C (2015)	1
RAD23B	1	USP25	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Xu D (2017)	2
UCHL3	1	STIP1	1	biochemical	Wan C (2015)	1
SUMO3	0	USPL1	5	pull down, enzymatic study, two hybrid	Schulz S (2012), Schulz S (2012), Rolland T (2014)	3
UBE2I	0	HIPK2	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, enzymatic study	Lee BH (2003), Bandyopadhyay S (2010), Sung KS (2005), Sung KS (2005), Hofmann TG (2005), Sung KS (2005)	6
SUMO3	0	PML	7	imaging technique	Cuchet-Lourenco D (2011)	1
MOV10	6	ECHS1	2	affinity chromatography technology	Castello A (2012)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
RAD23A	1	SUMO3	0	biochemical	Wan C (2015)	1
MOV10	6	TAGLN2	0	affinity chromatography technology	Castello A (2012)	1
SUMO3	0	ARC	1	affinity chromatography technology	Nair RR (2017)	1
PFKM	4	SUMO3	0	biochemical	Wan C (2015)	1
RAD23B	1	UBE3A	4	pull down, enzymatic study	Kumar S (1999), Kumar S (1999)	2
UBC	7	UFD1	1	pull down, x-ray crystallography, affinity chromatography technology, pull down	Nathan JA (2013), Park S (2005), Bish RA (2007), Zhang X (2017)	4
ANXA7	0	VIM	0	two hybrid	Vinayagam A (2011)	1
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
MTAP	3	SUMO3	0	biochemical	Wan C (2015)	1
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
SUMO3	0	ECHS1	2	biochemical	Wan C (2015)	1
UBA2	0	RAD23B	1	biochemical	Kristensen AR (2012)	1
HIPK2	0	SENP2	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Hofmann TG (2005), Hofmann TG (2005), Hofmann TG (2005)	3
UPF2	2	TK1	0	two hybrid	Lehner B (2004)	1
EWSR1	2	RAD23A	1	two hybrid	Rual JF (2005)	1
UBE2I	0	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
TAGLN3	2	STIP1	1	biochemical	Wan C (2015)	1
NXF1	0	PFKM	4	affinity chromatography technology	Castello A (2012)	1
SUMO3	0	CHAF1A	1	two hybrid, pull down, pull down	Uwada J (2010), Uwada J (2010), Uwada J (2010)	3
ISYNA1	0	PGD	2	biochemical	Wan C (2015)	1
TTR	0	VIM	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ARC	1	UBE3A	4	pull down	Kuehnle S (2013)	1
FKBP2	0	SUMO3	0	biochemical	Wan C (2015)	1
USPL1	5	PGD	2	affinity chromatography technology	Sowa ME (2009)	1
SUMO3	0	TAGLN2	0	biochemical	Wan C (2015)	1
ISYNA1	0	ECHS1	2	biochemical	Wan C (2015)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
TAGLN2	0	STIP1	1	biochemical	Wan C (2015)	1
NXF1	0	USPL1	5	affinity chromatography technology	Castello A (2012)	1
PFDN1	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
ARHGDIA	3	PFKM	4	biochemical	Wan C (2015)	1
UPF2	2	SUMO3	0	two hybrid	Lehner B (2004)	1
PGD	2	SUMO3	0	biochemical	Wan C (2015)	1
USP25	0	SENP2	3	affinity chromatography technology	Xu D (2017)	1
ENO2	1	UCHL3	1	biochemical	Wan C (2015)	1
UFD1	1	SUMO3	0	biochemical	Wan C (2015)	1
SENP1	0	SUMO3	0	enzymatic study, enzymatic study, pull down, enzymatic study	Shen LN (2006), Gong L (2006), Schulz S (2012), Schulz S (2012)	4
USPL1	5	SP100	4	enzymatic study	Schulz S (2012)	1
TK1	0	DRAP1	2	two hybrid	Stelzl U (2005)	1
MOV10	6	ANXA7	0	affinity chromatography technology	Castello A (2012)	1
PIAS2	2	PML	7	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Cuchet-Lourenco D (2011), Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	4
CDKN1A	1	SUMO3	0	two hybrid	Vinayagam A (2011)	1
ARHGDIA	3	SUMO3	0	biochemical	Wan C (2015)	1
RAD23A	1	VIM	0	affinity chromatography technology	Chen L (2006)	1
ARHGDIA	3	EWSR1	2	affinity chromatography technology, bioid	Ewing RM (2007), Elzi DJ (2014)	2
SEC23A	3	SP100	4	biochemical	Havugimana PC (2012)	1
RAD23A	1	USP25	0	affinity chromatography technology, two hybrid	Scanlon TC (2009), Rolland T (2014)	2
SUMO3	0	IRF7	2	imaging technique	Chang PC (2013)	1
RAD23A	1	UBE3A	4	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid	Kumar S (1999), Kumar S (1999), Scanlon TC (2009), Kuehnle S (2013), Kumar S (1997), Mortensen F (2015), Kim HT (2007), Cooper EM (2004), Cooper EM (2004)	9
SENP2	3	DAXX	5	enzymatic study	Lin DY (2006)	1
UBE2I	0	TDP2	2	two hybrid	Lee BH (2003)	1
EWSR1	2	STIP1	1	bioid	Elzi DJ (2014)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
MAPKAPK3	0	SUMO3	0	two hybrid	Vinayagam A (2011)	1
UFD1	1	STIP1	1	biochemical	Wan C (2015)	1
CDKN1A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
DRAP1	2	RAD23B	1	biochemical	Kristensen AR (2012)	1
SENP1	0	SP100	4	enzymatic study	Schulz S (2012)	1
UBE3A	4	SUMO3	0	two hybrid	Vinayagam A (2011)	1
SUMO3	0	TAGLN3	2	biochemical	Wan C (2015)	1
SUMO3	0	MAPRE1	0	biochemical	Wan C (2015)	1
NXF1	0	ANXA7	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	UFD1	1	affinity chromatography technology	Castello A (2012)	1
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
TAGLN3	2	TAGLN2	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2