PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNAAF2	2	SNCA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DGUOK	1	APP	1	pull down	Olah J (2011)	1
DNAAF2	2	APP	1	pull down	Olah J (2011)	1
GRK6	3	SNCA	0	enzymatic study	Pronin AN (2000)	1
ARMC1	2	APP	1	pull down	Olah J (2011)	1
PLK3	0	SNCB	0	enzymatic study	Mbefo MK (2010)	1
SNCA	0	AKT1	1	affinity chromatography technology, far western blotting	Chung JY (2011), Chung JY (2011)	2
NUFIP1	0	SNCA	0	affinity chromatography technology	Huttlin EL (2015)	1
NUFIP1	0	SNCB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRK1	1	SNCA	0	enzymatic study	Pronin AN (2000)	1
GRK1	1	SNCB	0	enzymatic study	Pronin AN (2000)	1
HSPA1A	0	SNCB	0	fluorescent resonance energy transfe	Roodveldt C (2009)	1
HSPA1A	0	SNCA	0	fluorescent resonance energy transfe, pull down	Roodveldt C (2009), Roodveldt C (2009)	2
PLK1	0	SNCA	0	enzymatic study	Mbefo MK (2010)	1
DGUOK	1	SNCB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
GRK5	7	SNCB	0	enzymatic study	Pronin AN (2000)	1
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
GRK5	7	SNCA	0	enzymatic study	Pronin AN (2000)	1
PLK1	0	SNCB	0	enzymatic study	Mbefo MK (2010)	1
SNCB	0	SNCA	0	affinity chromatography technology	Hashimoto M (2001)	1
ARMC1	2	SNCB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	SNCB	0	pull down	Jensen PH (1997)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
AKT1	1	SNCB	0	two hybrid	Arroyo R (2015)	1
GRK6	3	SNCB	0	enzymatic study	Pronin AN (2000)	1
LNX1	7	SNCB	0	pull down	Wolting CD (2011)	1
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PLK3	0	SNCA	0	enzymatic study	Mbefo MK (2010)	1
DNAAF2	2	SNCB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DGUOK	1	SNCA	0	affinity chromatography technology	Huttlin EL (2015)	1
GRK6	3	GRK5	7	affinity chromatography technology	Huttlin EL (2017)	1