PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP1LC3B	1	BNIP3	2	affinity chromatography technology, imaging technique, pull down	Zhu Y (2013), Zhu Y (2013), Zhu Y (2013)	3
BNIP3	2	BNIP3L	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
CREB3	1	BNIP3	2	two hybrid	Yu H (2011)	1
NCBP1	7	BNIP3	2	two hybrid	Kataoka N (1995)	1
PPTC7	0	BNIP3L	1	affinity chromatography technology	Floyd BJ (2016)	1
BNIP3L	1	CLEC7A	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
BNIP3	2	BNIP3	2	two hybrid, pull down, two hybrid, pull down, two hybrid	Rual JF (2005), Chen G (1997), Chen G (1997), Ray R (2000), Rolland T (2014)	5
HDAC1	4	MAP1LC3B	1	genetic interference	Xie HJ (2012)	1
CLN8	0	TMEM11	2	two hybrid	Passantino R (2013)	1
BCL2L1	0	PINK1	2	affinity chromatography technology	Hollville E (2014)	1
BNIP3	2	TMEM11	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	4
MAP1LC3B	1	BNIP3L	1	affinity chromatography technology	Novak I (2010)	1
PRKN	1	BCL2	0	pull down, affinity chromatography technology	Chen D (2010), Chen D (2010)	2
LMNA	2	BNIP3L	1	two hybrid	Dittmer TA (2014)	1
KTN1	1	CLEC7A	3	two hybrid	Rolland T (2014)	1
PINK1	2	TGM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Min B (2015), Min B (2015), Min B (2015), Min B (2015)	4
PRKN	1	OPA1	4	affinity chromatography technology	Zanon A (2013)	1
BNIP3	2	HDAC1	4	affinity chromatography technology	Burton TR (2009)	1
PPP4R3B	3	TGM2	2	biochemical	Kristensen AR (2012)	1
CLN8	0	BNIP3	2	two hybrid	Passantino R (2013)	1
BNIP3	2	LDLRAD1	2	two hybrid	Rolland T (2014)	1
BNIP3	2	TGM2	2	two hybrid	Wang J (2011)	1
ENPEP	1	BNIP3	2	affinity chromatography technology	Huttlin EL (2017)	1
CLN8	0	BNIP3L	1	two hybrid	Passantino R (2013)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
BNIP3	2	PPP4R3B	3	affinity chromatography technology	Huttlin EL (2017)	1
LMNA	2	TMEM11	2	two hybrid	Dittmer TA (2014)	1
PRKN	1	BNIP3	2	imaging technique	Zhang T (2016)	1
CREB3	1	BCL2L1	0	two hybrid	Yu H (2011)	1
BCL2	0	BNIP3	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boyd JM (1994), Ray R (2000), Wang Y (2013), Wang Y (2013)	4
RHEB	2	BNIP3L	1	two hybrid	Li Y (2007)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
TMEM30A	1	BNIP3	2	affinity chromatography technology	Huttlin EL (2015)	1
PPTC7	0	BNIP3	2	affinity chromatography technology, affinity chromatography technology	Floyd BJ (2016), Huttlin EL (2017)	2
RHEB	2	BNIP3	2	two hybrid, fluorescent resonance energy transfe	Li Y (2007), Li Y (2007)	2
BCL2	0	BNIP3L	1	affinity chromatography technology, pull down	Imazu T (1999), Yasuda M (1999)	2
PINK1	2	BNIP3	2	affinity chromatography technology, affinity chromatography technology	Zhang T (2016), Zhang T (2016)	2
OPA1	4	BNIP3	2	affinity chromatography technology, two hybrid, pull down	Landes T (2010), Landes T (2010), Landes T (2010)	3
BCL2L1	0	BNIP3L	1	pull down	Yasuda M (1999)	1
BNIP3	2	HIVEP1	13	two hybrid	Wang J (2011)	1
LMNA	2	FATE1	0	two hybrid	Dittmer TA (2014)	1
LMNA	2	BNIP3	2	two hybrid	Dittmer TA (2014)	1
BNIP3	2	KTN1	1	two hybrid	Rolland T (2014)	1
PRKN	1	LMNA	2	affinity chromatography technology	Zanon A (2013)	1
BNIP3L	1	FATE1	0	two hybrid	Rolland T (2014)	1
BNIP3	2	FATE1	0	two hybrid	Rolland T (2014)	1
BCL2L1	0	BNIP3	2	two hybrid, two hybrid, affinity chromatography technology	Ray R (2000), Ray R (2000), Ray R (2000)	3
BNIP3L	1	LDLRAD1	2	two hybrid	Rolland T (2014)	1
CREB3	1	RHEB	2	two hybrid	Yu H (2011)	1
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
TMEM11	2	FATE1	0	two hybrid	Yu H (2011)	1
BNIP3	2	CLEC7A	3	two hybrid	Rolland T (2014)	1
BNIP3L	1	TMEM11	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
BCL2L1	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hollville E (2014), Hollville E (2014), Gong Y (2017), Gong Y (2017), Gong Y (2017)	5
CD47	1	BNIP3	2	two hybrid, affinity chromatography technology	Lamy L (2003), Lamy L (2003)	2