PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP1LC3B	1	BNIP3	2	affinity chromatography technology, imaging technique, pull down	Zhu Y (2013), Zhu Y (2013), Zhu Y (2013)	3
BNIP3	2	BNIP3L	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
PPTC7	0	BNIP3L	1	affinity chromatography technology	Floyd BJ (2016)	1
BNIP3L	1	CLEC7A	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CLN8	0	TMEM11	2	two hybrid	Passantino R (2013)	1
GABARAPL1	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
BNIP3	2	TMEM11	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	4
GABARAPL2	0	BNIP3L	1	affinity chromatography technology	Novak I (2010)	1
MAP1LC3B	1	BNIP3L	1	affinity chromatography technology	Novak I (2010)	1
LMNA	2	BNIP3L	1	two hybrid	Dittmer TA (2014)	1
CLN8	0	BNIP3	2	two hybrid	Passantino R (2013)	1
BNIP3	2	LDLRAD1	2	two hybrid	Rolland T (2014)	1
BNIP3L	1	EWSR1	2	two hybrid	Rual JF (2005)	1
MAP1LC3B	1	GABARAPL2	0	pull down	Maruyama Y (2014)	1
ATP13A2	1	BNIP3L	1	two hybrid, affinity chromatography technology	Usenovic M (2012), Usenovic M (2012)	2
CLN8	0	BNIP3L	1	two hybrid	Passantino R (2013)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
GABARAPL1	0	BNIP3L	1	affinity chromatography technology	Novak I (2010)	1
STEAP3	2	BNIP3L	1	affinity chromatography technology, two hybrid	Passer BJ (2003), Passer BJ (2003)	2
LMNA	2	TMEM11	2	two hybrid	Dittmer TA (2014)	1
BCL2	0	BNIP3	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boyd JM (1994), Ray R (2000), Wang Y (2013), Wang Y (2013)	4
RHEB	2	BNIP3L	1	two hybrid	Li Y (2007)	1
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
PPTC7	0	BNIP3	2	affinity chromatography technology, affinity chromatography technology	Floyd BJ (2016), Huttlin EL (2017)	2
BNIP3L	1	CAMK1D	4	two hybrid	Wang J (2011)	1
RHEB	2	BNIP3	2	two hybrid, fluorescent resonance energy transfe	Li Y (2007), Li Y (2007)	2
CLN8	0	GABARAPL2	0	two hybrid	Passantino R (2013)	1
BCL2	0	BNIP3L	1	affinity chromatography technology, pull down	Imazu T (1999), Yasuda M (1999)	2
BNIP3L	1	ROBO2	2	two hybrid	Vinayagam A (2011)	1
MAP1LC3B	1	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
BCL2L1	0	BNIP3L	1	pull down	Yasuda M (1999)	1
BNIP3L	1	GBP2	0	two hybrid	Vinayagam A (2011)	1
BNIP3L	1	GNB5	2	two hybrid	Vinayagam A (2011)	1
CASK	18	DUSP3	1	two hybrid	Wang J (2011)	1
LMNA	2	FATE1	0	two hybrid	Dittmer TA (2014)	1
BNIP3L	1	SMCO4	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LMNA	2	BNIP3	2	two hybrid	Dittmer TA (2014)	1
LMNA	2	SMCO4	0	two hybrid	Dittmer TA (2014)	1
BNIP3L	1	FATE1	0	two hybrid	Rolland T (2014)	1
WIPI2	5	BNIP3L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BNIP3	2	FATE1	0	two hybrid	Rolland T (2014)	1
BNIP3L	1	ECM1	1	two hybrid	Wang J (2011)	1
BNIP3L	1	DUSP3	1	two hybrid	Wang J (2011)	1
BNIP3L	1	KLHL23	0	two hybrid	Vinayagam A (2011)	1
BCL2L1	0	BNIP3	2	two hybrid, two hybrid, affinity chromatography technology	Ray R (2000), Ray R (2000), Ray R (2000)	3
BNIP3L	1	LDLRAD1	2	two hybrid	Rolland T (2014)	1
MAP1LC3A	0	GABARAPL1	0	imaging technique	Tanida I (2006)	1
BNIP3L	1	DOK5	0	two hybrid	Rual JF (2005)	1
TMEM11	2	FATE1	0	two hybrid	Yu H (2011)	1
BNIP3	2	CLEC7A	3	two hybrid	Rolland T (2014)	1
BNIP3L	1	TMEM11	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
BNIP3L	1	CASK	18	two hybrid	Wang J (2011)	1
CEP192	5	BNIP3L	1	affinity chromatography technology	Gomez-Ferreria MA (2012)	1
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
GABARAP	0	BNIP3L	1	affinity chromatography technology	Novak I (2010)	1
BNIP3L	1	BNIP3L	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3A	0	BNIP3L	1	affinity chromatography technology, affinity chromatography technology, pull down	Novak I (2010), Novak I (2010), Novak I (2010)	3