PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX2	4	NCOR1	9	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	FAHD2A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD23B	1	SOX2	4	affinity chromatography technology, imaging technique	Fong YW (2011), Fong YW (2011)	2
CHD4	22	GATAD2A	3	affinity chromatography technology, biochemical, affinity chromatography technology	Rahman S (2011), Havugimana PC (2012), Huttlin EL (2017)	3
MTA2	1	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Zhang Y (1998), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Quan J (2014), Wan C (2015)	8
SOX2	4	CUX1	7	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
CHD7	22	MTA1	3	affinity chromatography technology	Engelen E (2011)	1
SOX2	4	SMARCB1	1	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
CHD7	22	ARID1A	16	affinity chromatography technology	Engelen E (2011)	1
SOX2	4	USP7	14	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Cox JL (2013)	2
SOX2	4	CHD4	22	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Engelen E (2011)	2
POU5F1	0	DCAF1	5	affinity chromatography technology	Oliviero G (2015)	1
SOX2	4	MTA1	3	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	MSI2	1	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Cox JL (2013)	2
SOX2	4	ENPP4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHD4	22	RBBP4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Wan C (2015), Hauri S (2016)	9
CHD7	22	MTA2	1	affinity chromatography technology	Engelen E (2011)	1
NCOR1	9	RBBP4	3	biochemical	Havugimana PC (2012)	1
POU5F1	0	CCAR2	9	affinity chromatography technology	Oliviero G (2015)	1
CTNNB1	30	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Xu C (2013), Xu C (2013)	2
MECP2	36	NCOR1	9	pull down, pull down	Kokura K (2001), Kokura K (2001)	2
SMARCB1	1	RBBP4	3	biochemical	Sif S (2001)	1
SOX2	4	MECP2	36	affinity chromatography technology, affinity chromatography technology	Szulwach KE (2010), Szulwach KE (2010)	2
POU5F1	0	RAD23B	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Fong YW (2011), Fong YW (2011), Fong YW (2011), Oliviero G (2015)	4
PLPBP	4	MYEF2	2	biochemical	Wan C (2015)	1
MTA1	3	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Xue Y (1998), Cui S (2011), Cui S (2011), Chudnovsky Y (2014), Wan C (2015)	6
SOX2	4	CHD7	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Engelen E (2011), Engelen E (2011), Cox JL (2013)	4
SETD7	2	SOX2	4	enzymatic study, affinity chromatography technology	Fang L (2014), Fang L (2014)	2
RBBP4	3	HDAC3	5	pull down, pull down	Nicolas E (2001), Nicolas E (2001)	2
SOX2	4	DNAJA2	2	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	PAK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOX2	4	SUPT5H	2	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Huttlin EL (2015)	2
MTA2	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Cui S (2011), Wan C (2015)	4
POU5F1	0	USP7	14	affinity chromatography technology	Oliviero G (2015)	1
TBX2	1	SOX2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trowe MO (2013), Trowe MO (2013), Trowe MO (2013)	3
MTA1	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Cui S (2011), Cui S (2011), Rolland T (2014), Huttlin EL (2015), Alqarni SS (2014), Alqarni SS (2014), Alqarni SS (2014), Wan C (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016), Millard CJ (2016), Hauri S (2016)	15
RBBP4	3	GATAD2A	3	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Gong Z (2006), Havugimana PC (2012), Huttlin EL (2017), Hauri S (2016)	4
SOX2	4	PLPBP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOX2	4	ARID1A	16	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Xu C (2013), Xu C (2013)	3
SOX2	4	CCAR2	9	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Engelen E (2011)	2
SOX2	4	OXSM	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POU5F1	0	CHD7	22	affinity chromatography technology	Oliviero G (2015)	1
SOX2	4	MTA2	1	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Engelen E (2011)	2
SOX2	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	SERPINB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOX2	4	SOX14	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCB1	1	ARID1A	16	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical	Kato H (2002), Wang W (1996), Ryme J (2009), Havugimana PC (2012), Wan C (2015)	5
DCAF1	5	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Romani B (2016), Romani B (2016)	2
GATAD2A	3	MTA1	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
SOX2	4	DCAF1	5	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Huttlin EL (2015)	2
SOX2	4	FZR1	1	affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013)	2
NCOR1	9	SMARCB1	1	biochemical	Underhill C (2000)	1
SOX2	4	RBP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MECP2	36	SMARCB1	1	pull down	Harikrishnan KN (2005)	1
SOX2	4	PRTFDC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA2	1	RBBP4	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Banach-Orlowska M (2009), Pflum MK (2001), Feng Q (2001), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Wan C (2015), Brasen C (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	13
SOX2	4	GATAD2A	3	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
SOX2	4	MYEF2	2	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
MTA2	1	GATAD2A	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
CHD7	22	GATAD2A	3	affinity chromatography technology	Engelen E (2011)	1
POU5F1	0	SOX21	2	affinity chromatography technology	Oliviero G (2015)	1
SOX2	4	SOX21	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOX2	4	PAX6	3	affinity chromatography technology, affinity chromatography technology	Aota S (2003), Aota S (2003)	2
POU5F1	0	DNAJA2	2	affinity chromatography technology	Oliviero G (2015)	1
POU5F1	0	SOX2	4	pull down, affinity chromatography technology, affinity chromatography technology	Remenyi A (2003), Xu C (2013), Oliviero G (2015)	3