PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX5	11	ARID5A	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
FTH1	0	SOX5	11	two hybrid	Wang J (2011)	1
SOX5	11	SOX11	7	affinity chromatography technology	Huttlin EL (2017)	1
TAF6	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SOX5	11	391257	0	two hybrid	Rolland T (2014)	1
CBX8	3	KAT5	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Tan J (2011)	2
AES	2	LMO1	0	two hybrid	Rolland T (2014)	1
CDC25A	2	FTH1	0	two hybrid	Wang J (2011)	1
SOX5	11	ZNF581	0	two hybrid	Rolland T (2014)	1
CEP85	5	SOX13	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KAT5	1	APP	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down	Sumioka A (2005), Kinoshita A (2002), von Rotz RC (2004), von Rotz RC (2004), von Rotz RC (2004), Cao X (2004), Li Q (2004), Olah J (2011)	8
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
ZNF581	0	APP	1	pull down	Olah J (2011)	1
SOX2	4	SOX5	11	affinity chromatography technology	Engelen E (2011)	1
AES	2	SOX5	11	two hybrid	Rolland T (2014)	1
CDC25A	2	LMO2	2	two hybrid	Wang J (2011)	1
SMAD7	1	SOX13	4	two hybrid	Colland F (2004)	1
SMAD1	0	SOX5	11	two hybrid	Colland F (2004)	1
CDC25A	2	SOX5	11	two hybrid	Wang J (2011)	1
SOX5	11	MORN3	0	two hybrid	Rolland T (2014)	1
SOX2	4	CDC23	3	affinity chromatography technology	Cox JL (2013)	1
CRX	0	SOX5	11	two hybrid	Rolland T (2014)	1
AES	2	LMO2	2	two hybrid	Rolland T (2014)	1
SOX2	4	SOX6	1	affinity chromatography technology	Cox JL (2013)	1
SOX5	11	TTC1	3	two hybrid	Wang J (2011)	1
CEP85	5	SOX5	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD7	1	SOX5	11	two hybrid	Colland F (2004)	1
SOX5	11	KAT5	1	two hybrid	Rolland T (2014)	1
KIFC3	3	APP	1	pull down	Olah J (2011)	1
AES	2	KIFC3	3	two hybrid	Rolland T (2014)	1
LMO2	2	SOX5	11	two hybrid	Rolland T (2014)	1
SOX5	11	CDC23	3	two hybrid	Rolland T (2014)	1
CDK6	0	SOX5	11	enzymatic study	Anders L (2011)	1
SOX5	11	CBX8	3	two hybrid	Rolland T (2014)	1
KIFC3	3	SOX5	11	two hybrid	Rolland T (2014)	1
SOX5	11	SOX6	1	affinity chromatography technology	Huttlin EL (2017)	1
SOX5	11	ANKRD40	1	affinity chromatography technology	Huttlin EL (2017)	1
SMAD1	0	APP	1	pull down	Olah J (2011)	1
MED27	0	SOX5	11	two hybrid	Wang J (2011)	1
SMAD5	2	SOX5	11	two hybrid	Colland F (2004)	1
KIFC3	3	CBX8	3	two hybrid	Rolland T (2014)	1
LMO1	0	SOX5	11	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RPS2	3	SOX5	11	two hybrid	Wang J (2011)	1
SOX5	11	PRR20A	0	two hybrid	Rolland T (2014)	1
SOX5	11	SOX1	1	affinity chromatography technology	Huttlin EL (2017)	1
SOX5	11	TAF6	4	affinity chromatography technology	Cimadamore F (2013)	1
SOX5	11	FAM46B	2	two hybrid	Rolland T (2014)	1
SOX5	11	APP	1	pull down	Olah J (2011)	1
AES	2	CRX	0	two hybrid	Rolland T (2014)	1
SOX5	11	UQCRFS1	0	two hybrid	Wang J (2011)	1
SOX5	11	SOX5	11	two hybrid	Rolland T (2014)	1
CDC25A	2	APP	1	pull down	Olah J (2011)	1
SOX5	11	SOX13	4	affinity chromatography technology	Huttlin EL (2017)	1
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1