PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	MAF	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen Q (2002), Chen Q (2002), Chen Q (2002)	3
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
EP300	36	SOX9	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furumatsu T (2010), Furumatsu T (2010), Tsuda M (2003), Furumatsu T (2005)	4
SOX9	2	MAF	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Huang W (2002), Huang W (2002), Huang W (2002), Huang W (2002), Huang W (2002)	5
ATP6V1H	1	SOX9	2	two hybrid	Wang J (2011)	1
SOX9	2	HSPA1A	0	affinity chromatography technology	Marshall OJ (2001)	1
RUNX2	2	SOX9	2	fluorescent resonance energy transfe	Cheng A (2010)	1
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
GSK3B	1	SOX9	2	enzymatic study	Hong X (2016)	1
UBE2I	0	ZBTB7A	3	enzymatic study	Roh HE (2007)	1
SMAD3	1	SOX9	2	affinity chromatography technology	Furumatsu T (2005)	1
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
SOX9	2	FBXW7	2	affinity chromatography technology, pull down	Hong X (2016), Hong X (2016)	2
ELF3	0	BTRC	1	affinity chromatography technology	Manavathi B (2007)	1
EP300	36	RUNX2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee HW (2006), Jeon EJ (2006), Jeon EJ (2006), Jun JH (2010)	4
SOX9	2	ZBTB7A	3	affinity chromatography technology	Wang G (2013)	1
FBXW7	2	MED12	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Davis MA (2013), Kourtis N (2015)	3
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
UBE2I	0	SOX9	2	enzymatic study	Ogawa H (2009)	1
MAF	4	UBE2I	0	affinity chromatography technology	Leavenworth JW (2009)	1
SMAD2	5	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
UBE2I	0	NR5A1	1	enzymatic study	Ogawa H (2009)	1
SOX9	2	BTRC	1	affinity chromatography technology	Deng W (2015)	1
SOX9	2	CREB3L4	0	pull down	Tsuda M (2003)	1
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
ELF3	0	EP300	36	affinity chromatography technology	Wang H (2004)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
HERC1	12	SOX9	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Hattori T (2013), Hattori T (2013), Hattori T (2013)	3
SMAD2	5	SOX9	2	affinity chromatography technology	Furumatsu T (2005)	1
FBXW7	2	RUNX2	2	affinity chromatography technology	Kumar Y (2015)	1
EP300	36	HERC1	12	affinity chromatography technology	Jung SY (2005)	1
SOX9	2	NR5A1	1	two hybrid, pull down, affinity chromatography technology	De Santa Barbara P (1998), De Santa Barbara P (1998), De Santa Barbara P (1998)	3
GSK3B	1	BTRC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Kitagawa M (1999), Gao C (2014), Gao C (2014), Gao C (2014)	4
SOX9	2	SCX	0	affinity chromatography technology	Furumatsu T (2010)	1
SOX9	2	SOX9	2	pull down	Wilhelm D (2007)	1
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
SMAD3	1	RUNX2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Ohyama Y (2011)	4
ELF3	0	SOX9	2	pull down	Otero M (2017)	1
MED12	11	SOX9	2	two hybrid, pull down, pull down, affinity chromatography technology	Zhou R (2002), Zhou R (2002), Zhou R (2002), Zhou R (2002)	4