PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SP4	4	HIRA	5	affinity chromatography technology	Huttlin EL (2017)	1
POU2F1	5	SP4	4	two hybrid	Rolland T (2014)	1
SP4	4	ADAM15	2	two hybrid	Rolland T (2014)	1
COL8A1	3	SP4	4	two hybrid	Rolland T (2014)	1
NKX3-1	2	SP1	0	two hybrid	Simmons SO (2006)	1
CRX	0	SP1	0	affinity chromatography technology	Lerner LE (2005)	1
SP4	4	LMO3	0	two hybrid	Rolland T (2014)	1
SP4	4	SP1	0	genetic interference	Hagen G (1995)	1
FOXP2	13	SP4	4	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
SP4	4	VRK3	0	affinity chromatography technology	Huttlin EL (2017)	1
SP4	4	ATXN7L1	3	two hybrid	Rolland T (2014)	1
CRX	0	SP3	4	affinity chromatography technology	Lerner LE (2005)	1
NKX3-1	2	SP3	4	two hybrid	Simmons SO (2006)	1
SP4	4	SP3	4	genetic interference	Hagen G (1995)	1
SP4	4	PRR20A	0	two hybrid	Rolland T (2014)	1
SP4	4	SERF2	0	two hybrid	Rolland T (2014)	1
NKX3-1	2	SP4	4	two hybrid	Simmons SO (2006)	1
HIRA	5	NRF1	2	imaging technique	Pchelintsev NA (2013)	1
SP4	4	PTPRA	3	affinity chromatography technology	Huttlin EL (2017)	1
CRX	0	SP4	4	affinity chromatography technology, affinity chromatography technology	Lerner LE (2005), Lerner LE (2005)	2
E2F1	0	SP4	4	affinity chromatography technology, pull down	Rotheneder H (1999), Rotheneder H (1999)	2
HIRA	5	E2F1	0	imaging technique	Pchelintsev NA (2013)	1
SP3	4	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Goto T (2006), Goto T (2006), Choi HS (2002), Choi HS (2002), Walker GE (2001), Walker GE (2001), Xu Q (2000), Tang S (2004), Kwon JH (2003), Syddall CM (2013), Syddall CM (2013), Syddall CM (2013)	12
E2F1	0	SP3	4	affinity chromatography technology, pull down	Rotheneder H (1999), Rotheneder H (1999)	2
SP1	0	POU2F1	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Stroem AC (1996), Stroem AC (1996), Gunther M (2000), Lim K (2009), Lim K (2009)	5
SP4	4	207147	0	two hybrid	Rolland T (2014)	1
SP4	4	CIB3	0	two hybrid	Rolland T (2014)	1
NRF1	2	SP4	4	two hybrid	Rolland T (2014)	1
E2F1	0	SP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down	Lin SY (1996), Lin SY (1996), Rotheneder H (1999), Rotheneder H (1999), Karlseder J (1996), Karlseder J (1996), Doetzlhofer A (1999)	7