PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRSF2	0	U2AF1	0	two hybrid, two hybrid, two hybrid	Zhang WJ (1996), Hegele A (2012), Hegele A (2012)	3
SRSF2	0	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
SRSF3	5	PRPF38A	3	two hybrid, two hybrid, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Boldt K (2016)	3
LUC7L	2	SRRM1	2	affinity chromatography technology	Huttlin EL (2015)	1
ACIN1	6	SRPK2	1	two hybrid, two hybrid, affinity chromatography technology, enzymatic study	Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Jang SW (2009)	4
SRRM1	2	SRSF6	3	biochemical, affinity chromatography technology	McCracken S (2005), Le Hir H (2000)	2
SNRNP27	0	SRPK2	1	two hybrid, two hybrid, enzymatic study, two hybrid	Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Rolland T (2014)	4
SRSF1	0	U2AF2	7	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Havugimana PC (2012), Whisenant TC (2015), Whisenant TC (2015), Huttlin EL (2017)	5
SRPK2	1	YTHDC1	8	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
LUC7L2	0	U2AF1	0	biochemical	Wan C (2015)	1
RNPS1	1	SRRM1	2	affinity chromatography technology	Ewing RM (2007)	1
LUC7L	2	RBM23	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNPS1	1	SRPK2	1	affinity chromatography technology, two hybrid, two hybrid, two hybrid	Ewing RM (2007), Hegele A (2012), Hegele A (2012), Rolland T (2014)	4
LUC7L	2	SRSF1	0	affinity chromatography technology	Huttlin EL (2017)	1
SRRM1	2	RBM39	2	affinity chromatography technology, affinity chromatography technology	McCracken S (2005), Jung SY (2005)	2
SRPK2	1	SRSF2	0	enzymatic study, affinity chromatography technology, enzymatic study	Wang HY (1998), Varjosalo M (2013), Jang SW (2009)	3
LUC7L	2	SNRNP70	2	biochemical	Wan C (2015)	1
RBM39	2	ACIN1	6	affinity chromatography technology	Jung SY (2005)	1
DDX21	0	RBM39	2	biochemical	Havugimana PC (2012)	1
LUC7L2	0	DDX46	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNPS1	1	U2AF2	7	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Wan C (2015), Whisenant TC (2015), Huttlin EL (2017)	4
LUC7L2	0	SRSF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRSF6	3	RNPS1	1	two hybrid, biochemical	Rual JF (2005), Wan C (2015)	2
SRSF6	3	SRSF1	0	biochemical	Wan C (2015)	1
LUC7L	2	LUC7L2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNPS1	1	ACIN1	6	pull down, pull down, two hybrid, two hybrid, biochemical	Murachelli AG (2012), Murachelli AG (2012), Hegele A (2012), Hegele A (2012), Wan C (2015)	5
SNIP1	0	ACIN1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNRNP70	2	RBM39	2	biochemical	Wan C (2015)	1
LUC7L2	0	ACIN1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBM23	0	SRPK2	1	two hybrid, two hybrid, enzymatic study	Hegele A (2012), Hegele A (2012), Varjosalo M (2013)	3
SNIP1	0	SRPK2	1	two hybrid, two hybrid, enzymatic study	Hegele A (2012), Hegele A (2012), Lipp JJ (2015)	3
SNIP1	0	SRSF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNRNP70	2	ARGLU1	1	biochemical	Wan C (2015)	1
SNIP1	0	YTHDC1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRPK2	1	SRPK2	1	affinity chromatography technology, two hybrid, enzymatic study, enzymatic study	Varjosalo M (2013), Rolland T (2014), Sawasaki T (2008), Lipp JJ (2015)	4
SRPK2	1	SNRNP70	2	enzymatic study, two hybrid, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang HY (1998), Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Varjosalo M (2013), Lipp JJ (2015), Huttlin EL (2017)	7
SRSF1	0	SNRNP70	2	pull down, far western blotting, two hybrid, affinity chromatography technology	Xiao SH (1998), Cao W (1998), Cao W (1998), Huttlin EL (2017)	4
SNIP1	0	SRSF6	3	affinity chromatography technology	Huttlin EL (2015)	1
LUC7L	2	ACIN1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
U2AF1	0	ACIN1	6	affinity chromatography technology	Huttlin EL (2017)	1
U2AF2	7	SRSF6	3	affinity chromatography technology	Whisenant TC (2015)	1
SRPK2	1	DDX21	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Lipp JJ (2015)	4
U2AF2	7	ACIN1	6	affinity chromatography technology, affinity chromatography technology	Whisenant TC (2015), Huttlin EL (2017)	2
U2AF1	0	PRPF38A	3	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SRSF3	5	SRSF1	0	biochemical	Wan C (2015)	1
RNPS1	1	LUC7L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
SRSF1	0	U2AF1	0	pull down, two hybrid, biochemical, two hybrid	Xiao SH (1998), Zhang WJ (1996), Havugimana PC (2012), Wang J (2011)	4
SRPK2	1	HNRNPC	0	affinity chromatography technology, enzymatic study, enzymatic study	Varjosalo M (2013), Varjosalo M (2013), Lipp JJ (2015)	3
SRPK2	1	SRSF3	5	enzymatic study, enzymatic study, enzymatic study	Wang HY (1998), Varjosalo M (2013), Lipp JJ (2015)	3
ARGLU1	1	SRPK2	1	two hybrid, two hybrid, enzymatic study	Hegele A (2012), Hegele A (2012), Varjosalo M (2013)	3
SRPK2	1	LUC7L	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Lipp JJ (2015), Huttlin EL (2017)	6
U2AF2	7	SRRM1	2	affinity chromatography technology	Whisenant TC (2015)	1
RNPS1	1	SRSF1	0	affinity chromatography technology, two hybrid, two hybrid, biochemical	Ewing RM (2007), Hegele A (2012), Hegele A (2012), Wan C (2015)	4
LUC7L2	0	U2AF2	7	affinity chromatography technology, biochemical	Huttlin EL (2015), Wan C (2015)	2
SRRM1	2	DDX21	0	affinity chromatography technology	McCracken S (2005)	1
U2AF2	7	DDX21	0	affinity chromatography technology	Whisenant TC (2015)	1
RBM39	2	SRSF1	0	affinity chromatography technology	Jung SY (2005)	1
DDX21	0	RNPS1	1	biochemical	Havugimana PC (2012)	1
SNRNP27	0	ARGLU1	1	biochemical	Wan C (2015)	1
U2AF1	0	RNPS1	1	two hybrid, two hybrid, two hybrid	Hegele A (2012), Hegele A (2012), Rolland T (2014)	3
SRRM1	2	ACIN1	6	affinity chromatography technology	McCracken S (2005)	1
SRPK2	1	U2AF2	7	two hybrid, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Wang HY (1998), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2017)	6
RBM23	0	RBM39	2	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SRPK2	1	SRSF6	3	enzymatic study, affinity chromatography technology, enzymatic study	Wang HY (1998), Varjosalo M (2013), Lipp JJ (2015)	3
RNPS1	1	SNRNP70	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
SNRNP70	2	YTHDC1	8	affinity chromatography technology	Huttlin EL (2017)	1
SRSF6	3	PRPF38A	3	affinity chromatography technology	Boldt K (2016)	1
SRSF3	5	SRSF6	3	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
SNIP1	0	RNPS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRRM1	2	SRSF3	5	affinity chromatography technology, affinity chromatography technology	McCracken S (2005), Le Hir H (2000)	2
RNPS1	1	SRSF2	0	affinity chromatography technology	Ewing RM (2007)	1
PRPF38A	3	RNPS1	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SRRM1	2	RBM23	0	affinity chromatography technology	McCracken S (2005)	1
SRRM1	2	SRSF2	0	affinity chromatography technology	McCracken S (2005)	1
SRPK2	1	SRSF1	0	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Wang HY (1998), Umehara H (2003), Koizumi J (1999), Koizumi J (1999), Varjosalo M (2013)	5
SRPK2	1	SRRM1	2	fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study	Varjosalo M (2013), Varjosalo M (2013), Lipp JJ (2015)	3
AKT1	1	SRPK2	1	enzymatic study, affinity chromatography technology, pull down, imaging technique	Jang SW (2009), Jang SW (2009), Jang SW (2009), Jang SW (2009)	4
U2AF1	0	U2AF2	7	two hybrid, affinity chromatography technology, pull down, biochemical, two hybrid, two hybrid, two hybrid, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Zhang M (1992), Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Wang J (2011), Rolland T (2014), Wan C (2015), Yu H (2011), Whisenant TC (2015), Whisenant TC (2015), Huttlin EL (2017)	13
SRPK2	1	ZRSR2	0	enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
SNRNP70	2	SRSF3	5	biochemical	Wan C (2015)	1
LUC7L2	0	SNRNP27	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBM39	2	U2AF2	7	affinity chromatography technology, two hybrid, two hybrid	Jung SY (2005), Hegele A (2012), Hegele A (2012)	3
RNPS1	1	LUC7L2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
RBM39	2	LUC7L2	0	affinity chromatography technology	Jung SY (2005)	1
PRPF38A	3	SRPK2	1	two hybrid, two hybrid, enzymatic study, two hybrid, enzymatic study	Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Rolland T (2014), Lipp JJ (2015)	5
LUC7L2	0	SNRNP70	2	affinity chromatography technology, biochemical	Huttlin EL (2015), Wan C (2015)	2
RBM39	2	SRPK2	1	two hybrid, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study	Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Lipp JJ (2015)	8
SRSF3	5	SRSF2	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
LUC7L	2	U2AF2	7	affinity chromatography technology	Huttlin EL (2015)	1
RBM39	2	RNPS1	1	biochemical	Wan C (2015)	1
DDX46	1	SRPK2	1	two hybrid, two hybrid, affinity chromatography technology, enzymatic study	Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Lipp JJ (2015)	4
SRPK2	1	LUC7L2	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
U2AF1	0	SRPK2	1	two hybrid, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2017)	6
SRSF1	0	SRSF2	0	two hybrid, two hybrid, biochemical	Zhang WJ (1996), Zhang WJ (1996), Wan C (2015)	3
SRSF3	5	U2AF2	7	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015), Whisenant TC (2015)	3
SNRNP70	2	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
RBM39	2	PRPF38A	3	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
HNRNPC	0	RNPS1	1	biochemical	Havugimana PC (2012)	1
HNRNPC	0	U2AF2	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Whisenant TC (2015)	2
SNRNP27	0	DDX46	1	affinity chromatography technology	Huttlin EL (2017)	1
SRSF6	3	LUC7L2	0	two hybrid	Rolland T (2014)	1