PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XRCC6	3	JUP	7	biochemical	Kristensen AR (2012)	1
ELAVL1	0	RYK	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	HSPA8	4	affinity chromatography technology	Neganova I (2011)	1
CUL2	3	HSPA1A	0	affinity chromatography technology	Bennett EJ (2010)	1
XRCC6	3	DPYSL3	1	biochemical	Kristensen AR (2012)	1
NTRK1	1	CLIC4	3	affinity chromatography technology	Emdal KB (2015)	1
DAPK1	6	ST13	2	affinity chromatography technology, affinity chromatography technology	Zhang L (2007), Zhang L (2007)	2
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
F2	2	ST13	2	enzymatic study	Velten M (2002)	1
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
FUS	0	ST13	2	affinity chromatography technology	Wang T (2014)	1
CDK2	0	JUP	7	affinity chromatography technology	Neganova I (2011)	1
PACSIN2	0	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
CCND2	2	ST13	2	affinity chromatography technology	Russo LC (2017)	1
APOE	1	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
DSTN	0	VCP	6	biochemical	Havugimana PC (2012)	1
U2AF2	7	HSPA8	4	affinity chromatography technology	Whisenant TC (2015)	1
CCND2	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017)	3
ELAVL1	0	VAV2	6	affinity chromatography technology	Abdelmohsen K (2009)	1
MSH2	4	DPYSL3	1	biochemical	Kristensen AR (2012)	1
ST13	2	HEATR3	1	biochemical	Wan C (2015)	1
ST13	2	CFL2	0	biochemical	Wan C (2015)	1
ST13	2	PACSIN3	2	biochemical	Wan C (2015)	1
PSEN1	11	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
FN1	17	F2	2	affinity chromatography technology	Moussavi-Harami SF (2013)	1
NTRK1	1	HSPA1A	0	affinity chromatography technology	Emdal KB (2015)	1
ALB	1	APOE	1	affinity chromatography technology	Zhou M (2004)	1
XRCC6	3	MSH2	4	affinity chromatography technology, biochemical	Shahi A (2011), Kristensen AR (2012)	2
MSH2	4	JUP	7	biochemical	Kristensen AR (2012)	1
ALB	1	TTR	0	affinity chromatography technology	Zhou M (2004)	1
NTRK1	1	U2AF2	7	affinity chromatography technology	Emdal KB (2015)	1
U2AF2	7	CLIC1	0	affinity chromatography technology	Whisenant TC (2015)	1
ALB	1	FN1	17	affinity chromatography technology	Zhou M (2004)	1
CDK2	0	XRCC6	3	enzymatic study, affinity chromatography technology	Diederichs S (2004), So J (2015)	2
FN1	17	HSPA1A	0	affinity chromatography technology	Humphries JD (2009)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
ST13	2	PACSIN2	0	biochemical	Wan C (2015)	1
CDK2	0	FUS	0	affinity chromatography technology	Neganova I (2011)	1
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
FUS	0	HSP90AA1	7	affinity chromatography technology	Wang T (2014)	1
DPYSL3	1	CUL2	3	biochemical	Kristensen AR (2012)	1
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
U2AF2	7	VCP	6	affinity chromatography technology	Whisenant TC (2015)	1
NTRK1	1	CPNE1	0	affinity chromatography technology	Emdal KB (2015)	1
FN1	17	FUS	0	affinity chromatography technology	Humphries JD (2009)	1
U2AF2	7	ELAVL1	0	affinity chromatography technology	Whisenant TC (2015)	1
CLIC4	3	ST13	2	biochemical	Wan C (2015)	1
APOE	1	NOS3	7	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ST13	2	SUB1	0	biochemical	Wan C (2015)	1
FN1	17	HSP90AA1	7	affinity chromatography technology	Humphries JD (2009)	1
CDK2	0	DSTN	0	affinity chromatography technology	Neganova I (2011)	1
PACSIN2	0	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
SMAD2	5	HSPA4	3	affinity chromatography technology	Brown KA (2008)	1
HSP90AA1	7	ST13	2	affinity chromatography technology, pull down, pull down	Gano JJ (2010), Graumann K (2000), Sun L (2012)	3
CXCR4	0	ST13	2	affinity chromatography technology	Fan GH (2002)	1
PACSIN3	2	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
CTRC	1	ST13	2	enzymatic study	Velten M (2002)	1
FUS	0	ALB	1	affinity chromatography technology	Wang T (2014)	1
FUS	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Wang T (2014)	2
MSH2	4	CUL2	3	biochemical	Kristensen AR (2012)	1
FN1	17	ST13	2	affinity chromatography technology	Humphries JD (2009)	1
DAPK1	6	HSP90AA1	7	affinity chromatography technology	Zhang L (2007)	1
BAG3	4	CPNE1	0	affinity chromatography technology	Chen Y (2013)	1
FN1	17	SUB1	0	affinity chromatography technology	Humphries JD (2009)	1
NTRK1	1	HSPA8	4	affinity chromatography technology	Emdal KB (2015)	1
HSPA4	3	JUP	7	biochemical	Kristensen AR (2012)	1
CDK2	0	SMAD2	5	enzymatic study	Matsuura I (2004)	1
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
NTRK1	1	DPYSL3	1	affinity chromatography technology	Emdal KB (2015)	1
ELAVL1	0	CDC42	3	affinity chromatography technology	Abdelmohsen K (2009)	1
HSPA8	4	BAG3	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Takayama S (1999), Takayama S (1999), Takayama S (1999), Gentilella A (2011), Hishiya A (2011), Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Hein MY (2015)	11
TTR	0	VCP	6	affinity chromatography technology	Kadowaki H (2015)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ST13	2	DSTN	0	biochemical	Wan C (2015)	1
VCP	6	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bennett EJ (2010), Besten Wd (2012)	3
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
HSP90AA1	7	NOS3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Harris MB (2000), Harris MB (2000), Stepp DW (2002), Fontana J (2002), Fontana J (2002), Brouet A (2001), Brouet A (2001)	9
ST13	2	HSPA4	3	pull down	Graumann K (2000)	1
NTRK1	1	FUS	0	affinity chromatography technology	Emdal KB (2015)	1
IRAK1	1	BAG3	4	affinity chromatography technology	Li S (2011)	1
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
FN1	17	VCP	6	affinity chromatography technology	Humphries JD (2009)	1
CDC42	3	ST13	2	two hybrid	Bandyopadhyay S (2010)	1
U2AF2	7	HSPA1A	0	affinity chromatography technology	Whisenant TC (2015)	1
NTRK1	1	ST13	2	affinity chromatography technology	Emdal KB (2015)	1
IRAK1	1	ST13	2	affinity chromatography technology, affinity chromatography technology	De Nardo D (2005), De Nardo D (2005)	2
U2AF2	7	XRCC6	3	affinity chromatography technology	Whisenant TC (2015)	1
XRCC6	3	CUL2	3	biochemical	Kristensen AR (2012)	1
IRAK1	1	HSPA8	4	affinity chromatography technology	De Nardo D (2005)	1
CDK2	0	MSH2	4	affinity chromatography technology	Neganova I (2011)	1
TTR	0	ST13	2	two hybrid	Vinayagam A (2011)	1
FUS	0	HSPA8	4	affinity chromatography technology	Wang T (2014)	1
ELAVL1	0	HEATR3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	CLIC1	0	affinity chromatography technology	Neganova I (2011)	1
CPNE1	0	ST13	2	biochemical	Havugimana PC (2012)	1
APOE	1	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
ALB	1	F2	2	affinity chromatography technology	Zhou M (2004)	1
CDK2	0	DPYSL3	1	affinity chromatography technology	Neganova I (2011)	1
RYK	1	ST13	2	affinity chromatography technology	Berndt JD (2011)	1
CUL2	3	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	CLIC1	0	affinity chromatography technology	Humphries JD (2009)	1
NTRK1	1	JUP	7	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	SUB1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), So J (2015)	2
ST13	2	CLIC1	0	biochemical	Wan C (2015)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
NOS3	7	ST13	2	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
U2AF2	7	ST13	2	affinity chromatography technology	Whisenant TC (2015)	1
SMAD2	5	ST13	2	two hybrid	Colland F (2004)	1
BAG3	4	ST13	2	affinity chromatography technology	Chen Y (2013)	1
HSPA8	4	VCP	6	affinity chromatography technology, biochemical, affinity chromatography technology	Vij N (2006), Havugimana PC (2012), Yu CC (2013)	3
NTRK1	1	MSH2	4	affinity chromatography technology	Emdal KB (2015)	1
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
CD101	4	ST13	2	two hybrid	Stelzl U (2005)	1
VAV2	6	ST13	2	two hybrid	Thalappilly S (2008)	1
ST13	2	HSPA1A	0	pull down	Prapapanich V (1996)	1
VCP	6	HSPA1A	0	affinity chromatography technology	Yu CC (2013)	1
FN1	17	HSPA8	4	affinity chromatography technology	Humphries JD (2009)	1
ST13	2	HSPA8	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Velten M (2002), Tsukahara F (2000), Taipale M (2014), Taipale M (2014)	4
CDK2	0	ST13	2	affinity chromatography technology	Neganova I (2011)	1
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
FN1	17	ELAVL1	0	affinity chromatography technology	Humphries JD (2009)	1
XRCC6	3	ST13	2	biochemical	Kristensen AR (2012)	1
CUL2	3	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	CLIC1	0	affinity chromatography technology	Emdal KB (2015)	1
SMAD2	5	U2AF2	7	affinity chromatography technology	Brown KA (2008)	1
CUL2	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
OLFM2	4	ST13	2	two hybrid	Stelzl U (2005)	1
PSEN1	11	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NTRK1	1	XRCC6	3	affinity chromatography technology	Emdal KB (2015)	1
HSPA8	4	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	ST13	2	affinity chromatography technology	Zhou M (2004)	1
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
ELAVL1	0	SUB1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	CUL2	3	affinity chromatography technology	Emdal KB (2015)	1
CFL2	0	DSTN	0	two hybrid	Rolland T (2014)	1
CXCR2	3	ST13	2	two hybrid, pull down, affinity chromatography technology	Fan GH (2002), Fan GH (2002), Fan GH (2002)	3
ELAVL1	0	ST13	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	HSPA4	3	affinity chromatography technology	Neganova I (2011)	1
FN1	17	XRCC6	3	affinity chromatography technology	Humphries JD (2009)	1
VCP	6	ST13	2	affinity chromatography technology	Yu CC (2013)	1
IRAK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	De Nardo D (2005), De Nardo D (2005)	2
PACSIN3	2	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
BAG3	4	HSP90AA1	7	affinity chromatography technology	Chen Y (2013)	1
BAG3	4	HSPA1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2000), Antoku K (2001), Chen Y (2013), Hein MY (2015)	4
CUL2	3	FUS	0	affinity chromatography technology	Bennett EJ (2010)	1
ST13	2	CUL2	3	biochemical	Kristensen AR (2012)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
CCND2	2	CLIC1	0	affinity chromatography technology	Russo LC (2017)	1
HSP90AA1	7	U2AF2	7	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Whisenant TC (2015)	2
NOS3	7	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
CDK2	0	CLIC4	3	affinity chromatography technology	Neganova I (2011)	1
MSH2	4	ST13	2	biochemical	Kristensen AR (2012)	1
ST13	2	JUP	7	biochemical	Kristensen AR (2012)	1
FN1	17	CPNE1	0	affinity chromatography technology	Humphries JD (2009)	1
DPYSL3	1	JUP	7	biochemical	Kristensen AR (2012)	1
NTRK1	1	VAV2	6	affinity chromatography technology	Emdal KB (2015)	1
DPYSL3	1	ST13	2	biochemical	Kristensen AR (2012)	1
CUL2	3	JUP	7	affinity chromatography technology, biochemical	Bennett EJ (2010), Kristensen AR (2012)	2
NTRK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2