PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
JUN	0	STAT1	1	affinity chromatography technology, affinity chromatography technology	Zhang X (1999), Zhang X (1999)	2
TRIM28	1	STAT4	3	affinity chromatography technology	Tsuruma R (2008)	1
SH2D1B	0	STAT4	3	two hybrid	Grossmann A (2015)	1
STAT4	3	IL12RB2	3	unspecified method	Yao BB (1999)	1
STAT1	1	STAT4	3	pull down	Meier D (2011)	1
PIAS2	2	JUN	0	pull down, enzymatic study	Schmidt D (2002), Schmidt D (2002)	2
ADRB2	0	STAT4	3	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
TKT	2	STAT4	3	biochemical	Wan C (2015)	1
PDLIM2	0	STAT4	3	affinity chromatography technology	Tanaka T (2005)	1
JUN	0	STAT4	3	affinity chromatography technology	Nakahira M (2002)	1
PIAS2	2	STAT4	3	affinity chromatography technology	Arora T (2003)	1
TRIM28	1	STAT1	1	affinity chromatography technology, affinity chromatography technology	Kamitani S (2008), Tsuruma R (2008)	2
CRK	0	STAT4	3	two hybrid	Grossmann A (2015)	1