PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
AURKA	1	PEAK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	PUM2	5	affinity chromatography technology, affinity chromatography technology, pull down	Huang YH (2011), Huang YH (2011), Huang YH (2011)	3
FBXW7	2	NFKB1	2	affinity chromatography technology	Fekrmandi F (2015)	1
MTMR3	8	MTMR4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Hao F (2016), St-Denis N (2016), St-Denis N (2016), St-Denis N (2016), St-Denis N (2016), Li X (2016)	6
CDC20	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
AURKA	1	RASSF1	3	enzymatic study, fluorescent resonance energy transfe	Chow C (2011), Ivanov AA (2017)	2
CELA2B	1	AURKA	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXP1	23	AURKA	1	affinity chromatography technology, affinity chromatography technology, pull down	Kamran M (2017), Kamran M (2017), Kamran M (2017)	3
PPP1CC	2	HDAC6	0	biochemical, far western blotting, affinity chromatography technology, pull down	Brush MH (2004), Brush MH (2004), Brush MH (2004), Brush MH (2004)	4
GSK3B	1	NFKB1	2	enzymatic study	Demarchi F (2001)	1
MTMR3	8	PLK1	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
AURKA	1	LATS2	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, fluorescent resonance energy transfe	Yabuta N (2011), Toji S (2004), Toji S (2004), Toji S (2004), Toji S (2004), Ivanov AA (2017)	6
AURKA	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kwon YW (2012), Chou CH (2013), Chou CH (2013)	3
AURKA	1	AURKA	1	affinity chromatography technology, enzymatic study, genetic interference	Hutchins JR (2010), Tien AC (2004), Horlbeck MA (2018)	3
AURKA	1	NME1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Du J (2002), Du J (2002), Du J (2002), Du J (2002)	4
LATS2	1	CEP192	5	bioid	Couzens AL (2013)	1
APP	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhou F (2012), Zhou F (2012), Olah J (2011)	3
PPP1CA	3	PEAK1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
PPP1CA	3	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
AURKA	1	TARS	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NFKB1	2	TNKS1BP1	3	affinity chromatography technology	Boldt K (2016)	1
AURKA	1	EPS15	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	MAPRE2	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
BRCA1	7	SNX9	1	affinity chromatography technology	Ertych N (2016)	1
LATS2	1	RASSF1	3	fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Mo XL (2015), Mo XL (2015), Ivanov AA (2017)	3
TFAP2A	1	NFKB1	2	two hybrid	Xu Y (2008)	1
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
TP73	2	AURKA	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Katayama H (2012), Katayama H (2012), Katayama H (2012)	3
TUBG1	2	NME1	0	affinity chromatography technology	Fogeron ML (2013)	1
AURKA	1	PPP6R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	3
VHL	0	APP	1	pull down	Olah J (2011)	1
AURKA	1	OSBPL3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	MBD3	4	affinity chromatography technology, enzymatic study	Sakai H (2002), Sakai H (2002)	2
AURKA	1	TNKS1BP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	TARS	2	two hybrid, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
AURKA	1	BIRC5	1	affinity chromatography technology, enzymatic study	Fu J (2009), Fu J (2009)	2
CHFR	5	PML	7	fluorescent resonance energy transfe	Daniels MJ (2004)	1
VHL	0	TARS	2	affinity chromatography technology	Ewing RM (2007)	1
PPP1CB	9	TLK1	5	affinity chromatography technology	Boldt K (2016)	1
BRCA1	7	PRKCSH	2	affinity chromatography technology	Ertych N (2016)	1
AURKA	1	GMNN	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Tsunematsu T (2013), Tsunematsu T (2013), Tsunematsu T (2013)	3
PPP1CB	9	BRCA1	7	affinity chromatography technology, pull down	Winter SL (2007), Winter SL (2007)	2
MDM2	2	UBE2N	1	pull down	David Y (2011)	1
PPP6R3	2	AURKA	1	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	5
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SETD2	20	TP53	0	affinity chromatography technology, affinity chromatography technology	Xie P (2008), Xie P (2008)	2
FANCA	5	IKBKB	1	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Otsuki T (2002), Otsuki T (2002), Otsuki T (2002), Otsuki T (2002)	4
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
GSK3B	1	MDM2	2	enzymatic study, affinity chromatography technology	Kulikov R (2005), Kulikov R (2005)	2
CHFR	5	PLK1	0	enzymatic study, affinity chromatography technology	Kang D (2002), Oh YM (2009)	2
AURKA	1	MDM2	2	affinity chromatography technology, enzymatic study	Sehdev V (2013), Sehdev V (2013)	2
AURKA	1	MAPK6	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Rodriguez J (2016)	2
APP	1	TUBG1	2	pull down	Virok DP (2011)	1
AURKA	1	AMER1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TLK1	5	TLK2	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sillje HH (1999), Sillje HH (1999), Huttlin EL (2017)	3
AURKA	1	SNX9	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TUBG1	2	ARPC1B	1	affinity chromatography technology	Molli PR (2010)	1
MAPRE2	0	MAPRE3	0	two hybrid	Rual JF (2005)	1
AURKA	1	TLK2	16	affinity chromatography technology, enzymatic study	Li Z (2007), Li Z (2007)	2
MDM2	2	USP2	0	two hybrid, pull down, affinity chromatography technology, pull down	Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007)	4
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
AURKA	1	SDCCAG3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	MTMR4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW7	2	AURKA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Otto T (2009), Kwon YW (2012), Kwon YW (2012), Wang Y (2017)	4
PPP1CA	3	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji C (2002), Varjosalo M (2013), St-Denis N (2016)	3
PLK1	0	TUBG1	2	affinity chromatography technology	Feng Y (1999)	1
PPP1CA	3	SORL1	9	two hybrid	Esteves SL (2012)	1
TFAP2A	1	AURKA	1	affinity chromatography technology, affinity chromatography technology	Zou L (2011), Zou L (2011)	2
CDC20	1	GMNN	0	affinity chromatography technology, affinity chromatography technology	Pfleger CM (2001), Tsunematsu T (2013)	2
TCEAL2	0	APP	1	pull down	Olah J (2011)	1
PPP1CB	9	GSK3B	1	affinity chromatography technology	St-Denis N (2016)	1
ARPC1B	1	APP	1	pull down	Olah J (2011)	1
MAPK6	1	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
CHFR	5	CDC20	1	affinity chromatography technology	Oh YM (2009)	1
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
AURKA	1	WDR62	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LATS2	1	LIMD1	4	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Das Thakur M (2010)	3
AURKA	1	OSBPL6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC20	1	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Sedgwick GG (2012), Hyun SY (2013), Hyun SY (2013), Hyun SY (2013), Jia L (2016)	5
PRKCSH	2	AURKA	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP6R2	3	APP	1	pull down	Olah J (2011)	1
HDAC6	0	PML	7	affinity chromatography technology	Joshi P (2013)	1
EPS15	1	TFAP2A	1	pull down, pull down	Benmerah A (1998), Chi S (2008)	2
PPP1CA	3	AURKA	1	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001)	5
GMNN	0	CEP192	5	affinity chromatography technology	Huttlin EL (2017)	1
TPX2	4	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Hill SJ (2014)	3
PPP1CC	2	BIRC5	1	affinity chromatography technology	Flores-Delgado G (2007)	1
AURKA	1	NFKB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	WAPL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLK1	0	IKBKB	1	enzymatic study	Higashimoto T (2008)	1
PPP1CC	2	GSK3B	1	affinity chromatography technology	St-Denis N (2016)	1
KIRREL2	1	AURKA	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	UBE2N	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
VHL	0	AURKA	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin B (2013), Martin B (2013), Hasanov E (2017), Hasanov E (2017), Hasanov E (2017)	5
FOXP1	23	TP53	0	affinity chromatography technology	Li X (2015)	1
MDM2	2	LATS2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Aylon Y (2006), Aylon Y (2006), Aylon Y (2006)	3
HDAC6	0	BIRC5	1	affinity chromatography technology	Riolo MT (2012)	1
UBE2N	1	CHFR	5	two hybrid, pull down	Markson G (2009), Liu C (2013)	2
AURKA	1	MAPRE3	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
IKBKB	1	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li HY (2008), Mitsuhashi S (2008), Mitsuhashi S (2008)	3
AURKA	1	UBE2N	1	pull down, affinity chromatography technology, enzymatic study	Ewart-Toland A (2003), Ewart-Toland A (2003), Briassouli P (2006)	3
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TP53	0	ITPKC	0	affinity chromatography technology	Fogeron ML (2013)	1
PPP1CA	3	MDM2	2	affinity chromatography technology	Liu X (2016)	1
NFKB1	2	PML	7	two hybrid	Wang J (2011)	1
BRCA1	7	NME1	0	affinity chromatography technology	Ertych N (2016)	1
TP73	2	CDC20	1	affinity chromatography technology, affinity chromatography technology	Katayama H (2012), Katayama H (2012)	2
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
TPX2	4	IKBKB	1	affinity chromatography technology	Irelan JT (2007)	1
PPP1CC	2	AURKA	1	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001)	5
CDC20	1	RASSF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chow C (2011), Chow C (2011), Wang X (2008), Song MS (2004)	4
PPP1CA	3	BRCA1	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Winter SL (2007), Liu Y (2002), Liu Y (2002), Liu Y (2002), Liu Y (2002), Woods NT (2012), Chen BY (2014)	7
MDM2	2	DHX9	3	affinity chromatography technology, affinity chromatography technology	Okoro DR (2013), Jacob AG (2014)	2
AURKA	1	TPX2	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kufer TA (2002), Kufer TA (2002), Katayama H (2008), Trieselmann N (2003), Hutchins JR (2010), Maxwell CA (2011), Maxwell CA (2011), Fu J (2009), Huttlin EL (2015), Huttlin EL (2017), Ertych N (2016)	11
PPP1CC	2	TP53	0	affinity chromatography technology	Flores-Delgado G (2007)	1
PPP1CB	9	DHX9	3	affinity chromatography technology	Hein MY (2015)	1
LATS2	1	SDCCAG3	3	bioid	Couzens AL (2013)	1
AURKA	1	INCENP	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Katayama H (2008), Katayama H (2008), Katayama H (2008), Kaitna S (2000), Kaitna S (2000), Fu J (2009), Fu J (2009), Fu J (2009)	8
PPP6R3	2	PPP6R2	3	bioid	Couzens AL (2013)	1
PPP1CB	9	EPS15	1	affinity chromatography technology	Hein MY (2015)	1
AURKA	1	TNRC6C	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	TNRC6C	3	affinity chromatography technology	Ertych N (2016)	1
AURKA	1	SCYL1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	TUBG1	2	imaging technique, affinity chromatography technology, pull down, biochemical, imaging technique, affinity chromatography technology, enzymatic study, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Hsu LC (2001), Hsu LC (2001), Hsu LC (2001), Hsu LC (1998), Hsu LC (1998), Hsu LC (1998), Starita LM (2004), Brodie KM (2012), Tarapore P (2012), Tarapore P (2012), Tarapore P (2012), Matsuzawa A (2014)	12
TFAP2A	1	TP53	0	imaging technique, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	McPherson LA (2002), McPherson LA (2002), McPherson LA (2002), McPherson LA (2002), Stabach PR (2006), Stabach PR (2006)	6
AURKA	1	PASK	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLK1	0	FBXW7	2	affinity chromatography technology, enzymatic study	Xiao D (2016), Xiao D (2016)	2
VHL	0	LIMD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foxler DE (2012), Foxler DE (2012), Zhang CS (2015), Zhang CS (2015)	4
ARFGAP1	3	APP	1	pull down	Olah J (2011)	1
MAPK6	1	WAPL	1	affinity chromatography technology	Rodriguez J (2016)	1
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
TP73	2	IKBKB	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Accardi R (2011), Accardi R (2011), Accardi R (2011), Accardi R (2011)	4
PML	7	SH3GL1	3	two hybrid	Wang J (2011)	1
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
AURKA	1	HIST3H3	0	enzymatic study, enzymatic study, enzymatic study	Ban R (2011), Molli PR (2010), Fu J (2009)	3
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
TP53	0	PTTG1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bernal JA (2002), Bernal JA (2002), Bernal JA (2002), Kim HS (2009)	4
BRCA1	7	WAPL	1	affinity chromatography technology	Hill SJ (2014)	1
CALCOCO1	2	APP	1	pull down	Olah J (2011)	1
PLK1	0	PPP6R2	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Couzens AL (2013), Couzens AL (2013), Huttlin EL (2015), Huttlin EL (2017)	5
TACC1	2	AURKA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Delaval B (2004), Conte N (2003), Tien AC (2004)	3
CDC20	1	PTTG1	0	enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Braunstein I (2007), Eytan E (2006), Pfleger CM (2001), Kim HS (2009), Kwan PS (2013), Tian W (2012), Van Voorhis VA (2014), Lara-Gonzalez P (2011), Wu T (2010), Izawa D (2014), Hellmuth S (2014), Wu T (2010), Shoji S (2014), Lara-Gonzalez P (2011), Di Fiore B (2015), Lee SB (2015), Qiao R (2016), Alfieri C (2016), Izawa D (2012), Jia L (2016)	20
SCYL1	5	APP	1	pull down	Olah J (2011)	1
AURKA	1	TLK1	5	affinity chromatography technology, enzymatic study	Li Z (2007), Li Z (2007)	2
LATS2	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Yao F (2015), Yao F (2015)	2
CELA2B	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC6	0	GSK3B	1	affinity chromatography technology	Beurel E (2011)	1
GMNN	0	HMMR	1	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	HEATR5B	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	TACC3	1	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tien AC (2004), Tien AC (2004), Huttlin EL (2015), Huttlin EL (2017)	4
AURKA	1	CNOT8	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	AUNIP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DICER1	4	TARBP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chendrimada TP (2005), Li S (2014), Li S (2014)	3
AURKA	1	SORL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	3
AURKA	1	RPIA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	PLK1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Rodriguez J (2016)	2
AURKA	1	REL	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	CHFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Privette LM (2008), Oh YM (2009), Oh YM (2009)	3
CDC20	1	TUBG1	2	affinity chromatography technology	Kim AH (2009)	1
HIST3H3	0	BIRC5	1	unspecified method	Li X (2012)	1
AURKA	1	USP47	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CB	9	AURKA	1	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001)	5
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
SDCCAG3	3	APP	1	pull down	Olah J (2011)	1
PLK1	0	MDM2	2	enzymatic study, affinity chromatography technology, pull down	Dias SS (2009), Dias SS (2009), Dias SS (2009)	3
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
AURKA	1	USP2	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Shi Y (2011), Shi Y (2011), Shi Y (2011), Shi Y (2011), Shi Y (2011)	5
SORL1	9	APP	1	affinity chromatography technology	Schmidt V (2007)	1
TP53	0	AURKA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, genetic interference, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Katayama H (2004), Katayama H (2004), Katayama H (2004), Katayama H (2004), Hsueh KW (2013), Huttlin EL (2015), Huttlin EL (2017)	12
MDM2	2	HIST3H3	0	pull down, enzymatic study, affinity chromatography technology	Chen L (2010), Chen L (2010), Chen L (2010)	3
TARBP2	0	APP	1	pull down	Olah J (2011)	1
CDC20	1	HDAC6	0	affinity chromatography technology	Kim AH (2009)	1
RASSF1	3	GSK3B	1	affinity chromatography technology	Zhou X (2012)	1
PML	7	AURKA	1	affinity chromatography technology, affinity chromatography technology	Xu ZX (2005), Xu ZX (2005)	2
AURKA	1	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	HMMR	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Maxwell CA (2011)	3
AURKA	1	ITPKC	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	SNX18	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW7	2	PPP1CB	9	affinity chromatography technology	Kourtis N (2015)	1
TP53	0	TUBG1	2	affinity chromatography technology	Fogeron ML (2013)	1
CDC20	1	AURKA	1	affinity chromatography technology, affinity chromatography technology	Farruggio DC (1999), Katayama H (2012)	2
IKBKB	1	NFKB1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Heissmeyer V (2001), Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002), Chen TC (2014)	6
BRCA1	7	TP73	2	affinity chromatography technology	Ibrahim N (2010)	1
AURKA	1	DHX9	3	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), So J (2015)	2
TNRC6C	3	CNOT8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chekulaeva M (2011), Chekulaeva M (2011), Braun JE (2011)	3
AURKA	1	HDAC6	0	enzymatic study, pull down	Pugacheva EN (2007), Pugacheva EN (2007)	2
PLK1	0	OSBPL6	5	affinity chromatography technology	Svendsen JM (2009)	1
AURKA	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Irelan JT (2007), Irelan JT (2007), Irelan JT (2007)	3
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
AURKA	1	FANCA	5	enzymatic study, affinity chromatography technology	Chun MJ (2016), Chun MJ (2016)	2
BRCA1	7	USP2	0	two hybrid, two hybrid	Woods NT (2012), Hayes SD (2012)	2
AURKA	1	SYNRG	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	DICER1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	3
AURKA	1	SETD2	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DHX9	3	DICER1	4	affinity chromatography technology	Robb GB (2007)	1
HMMR	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Hill SJ (2014), Ertych N (2016)	4
PPP1CA	3	HDAC6	0	affinity chromatography technology	Chen CS (2005)	1
AURKA	1	TARBP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	KLHL18	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Moghe S (2012), Moghe S (2012), Moghe S (2012), Moghe S (2012)	4
PPP1CA	3	TP53	0	two hybrid	Colland F (2004)	1
LIMD1	4	APP	1	pull down	Olah J (2011)	1
AURKA	1	SH3GL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CC	2	PEAK1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
AURKA	1	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Ouchi M (2004), Ouchi M (2004), Maxwell CA (2011), Maxwell CA (2011), Ouchi M (2004), Ouchi M (2004), Ertych N (2016)	7
MAPRE2	0	APP	1	pull down	Olah J (2011)	1
DHX9	3	BRCA1	7	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Schlegel BP (2003), Anderson SF (1998), Anderson SF (1998), Ertych N (2016)	4
TP53	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTTG1	0	AURKA	1	pull down, genetic interference	Kim HS (2009), Horlbeck MA (2018)	2
AURKA	1	CEP192	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Hutchins JR (2010), Fogeron ML (2013), Huttlin EL (2015), Firat-Karalar EN (2014), Huttlin EL (2017)	5
FANCA	5	TUBG1	2	affinity chromatography technology, affinity chromatography technology	Kim S (2013), Kim S (2013)	2
ARPC1B	1	AURKA	1	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study	Molli PR (2010), Molli PR (2010), Molli PR (2010), Molli PR (2010), Molli PR (2010), Molli PR (2010)	6
SETD2	20	HIST3H3	0	enzymatic study	Kudithipudi S (2014)	1
AURKA	1	LIMD1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RASSF1	3	TUBG1	2	pull down	Liu L (2003)	1
DICER1	4	SCYL1	5	genetic interference	Horlbeck MA (2018)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
BRCA1	7	TFAP2A	1	affinity chromatography technology	Buckley NE (2011)	1
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
TUBG1	2	AURKA	1	affinity chromatography technology, affinity chromatography technology	Molli PR (2010), Molli PR (2010)	2
AURKA	1	ARFGAP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKA	1	TCEAL2	0	affinity chromatography technology, pull down	Fogeron ML (2013), Kamran M (2017)	2
AURKA	1	MTMR3	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Li X (2016), Huttlin EL (2017)	3
HIST3H3	0	MBD3	4	unspecified method	Li X (2012)	1
BIRC5	1	INCENP	4	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Wheatley SP (2001), Wheatley SP (2001), Xu Z (2009), Vader G (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Huttlin EL (2017)	11
BRCA1	7	PPP6R3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016), Ertych N (2016)	3
HDAC6	0	USP47	4	affinity chromatography technology	Joshi P (2013)	1
BRCA1	7	FANCA	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Folias A (2002), Folias A (2002), Folias A (2002), Suhasini AN (2011)	4
AURKA	1	PLK1	0	affinity chromatography technology, biochemical	Katayama H (2008), Havugimana PC (2012)	2
KIRREL2	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	RASSF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song MS (2008), Zhang H (2013), Zhang H (2013)	3
LATS2	1	AMER1	0	bioid	Couzens AL (2013)	1
TPX2	4	HMMR	1	affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011)	2